Gut-brain communication in demyelinating disorders.

Animals Brain Dysbiosis Gastrointestinal Microbiome Humans Intestines Multiple Sclerosis

Journal

Current opinion in neurobiology
ISSN: 1873-6882
Titre abrégé: Curr Opin Neurobiol
Pays: England
ID NLM: 9111376

Informations de publication

Date de publication:
06 2020
Historique:
received: 19 12 2019
revised: 11 01 2020
accepted: 12 01 2020
pubmed: 18 2 2020
medline: 12 9 2020
entrez: 18 2 2020
Statut: ppublish

Résumé

Multiple Sclerosis (MS) is an autoimmune demyelinating disorder resulting from the interplay of genetic predisposition and environmental variables, including gut microbiota, diet and life style factors. Here, we first discuss the evidence supporting the effect of early life events, diet and body mass index on the composition of the microbiota, and then review studies on gut dysbiosis conducted in MS patients and in animal models. We address the effect of disease, immunomodulatory therapies, diet and probiotics on enrichment or depletion of gut microbial species. Finally, we discuss the ability of gut bacteria to produce toxins and metabolites which serve as signals for the cross-talk between the gut and the brain.

Identifiants

DOI: 10.1016/j.conb.2020.01.005 PMID: 32066076 PMC: PMC7712523
pubmed: 32066076
pii: S0959-4388(20)30006-4
doi: 10.1016/j.conb.2020.01.005
pmc: PMC7712523
mid: NIHMS1569214
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

92-101

Subventions

Organisme : NINDS NIH HHS
ID : R35 NS111604
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

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Auteurs

Sami Sauma (S)

Neuroscience Initiative, Advanced Science Research Center, The Graduate Center at the City University of New York, New York, NY, USA; Graduate Program in Biology, The Graduate Center at the City University of New York, New York, NY, USA.

Patrizia Casaccia (P)

Neuroscience Initiative, Advanced Science Research Center, The Graduate Center at the City University of New York, New York, NY, USA; Graduate Program in Biology, The Graduate Center at the City University of New York, New York, NY, USA; Program in Biochemistry The Graduate Center at The City University of New York, New York, NY, USA. Electronic address: pcasaccia@gc.cuny.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Gut-brain communication in demyelinating disorders.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Gut-brain communication in demyelinating disorders.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Dysbiose › Gut-brain communication in demyelinating disorders.
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Gut-brain communication in demyelinating disorders.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Gut-brain communication in demyelinating disorders.
questionsmedicales.fr › Système digestif › Tube digestif › Intestins › Gut-brain communication in demyelinating disorders.
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Gut-brain communication in demyelinating disorders.