Epigenetics of T cell fate decision.

Animals Chromatin / immunology Epigenesis, Genetic / genetics Humans Infections / immunology Neoplasms / immunology T-Lymphocytes / cytology

Journal

Current opinion in immunology
ISSN: 1879-0372
Titre abrégé: Curr Opin Immunol
Pays: England
ID NLM: 8900118

Informations de publication

Date de publication:
04 2020
Historique:
received: 03 11 2019
accepted: 07 01 2020
pubmed: 18 2 2020
medline: 25 6 2021
entrez: 18 2 2020
Statut: ppublish

Résumé

The changes of transcription factor activity and chromatin dynamics guide functional differentiation of T cell subsets, including commitment to short-lived effectors and long-term survival of memory T cells. Understanding the lineage relationships among the different stages of effector and memory differentiation has profound therapeutic implications for the development of new vaccine and immunotherapy protocols. Here we review the contribution of chromatin architecture to T cell specification, focusing on the interplay between epigenetic changes and transcriptional programs linked to T cell plasticity, commitment and memory. We will also discuss the translational implications of epigenetic control in the context of infections and cancer.

Identifiants

DOI: 10.1016/j.coi.2020.01.002 PMID: 32066083
pubmed: 32066083
pii: S0952-7915(20)30002-9
doi: 10.1016/j.coi.2020.01.002
pii:
doi:

Substances chimiques

Chromatin 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

43-50

Informations de copyright

Copyright © 2020. Published by Elsevier Ltd.

Auteurs

Luigia Pace (L)

Armenise-Harvard Immune Regulation Unit, IIGM, FPO-IRCCS Candiolo, Turin, Italy. Electronic address: luigia.pace@iigm.it.

Sebastian Amigorena (S)

Institut Curie, PSL Research University, Paris, France; INSERM U932, France. Electronic address: sebastian.amigorena@curie.fr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Epigenetics of T cell fate decision.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Epigenetics of T cell fate decision.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Epigenetics of T cell fate decision.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Epigenetics of T cell fate decision.
questionsmedicales.fr › Infection › Epigenetics of T cell fate decision.
questionsmedicales.fr › Tumeurs › Epigenetics of T cell fate decision.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Epigenetics of T cell fate decision.