Randomised controlled trial to investigate the relationship between mild hypercapnia and cerebral oxygen saturation in patients undergoing major surgery.
Blood Gas Analysis
/ methods
Brain
/ blood supply
Carbon Dioxide
/ analysis
Cerebrovascular Circulation
/ physiology
Delirium
/ diagnosis
Female
Humans
Hypercapnia
/ blood
Intraoperative Care
/ methods
Length of Stay
/ statistics & numerical data
Male
Middle Aged
Outcome Assessment, Health Care
Oxygen
/ analysis
Oxygen Consumption
Postoperative Cognitive Complications
/ etiology
Respiration, Artificial
/ methods
Spectroscopy, Near-Infrared
/ methods
Surgical Procedures, Operative
/ adverse effects
delirium
hypercapnia
oximetry
respiration, artificial
spectroscopy, near infrared
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
16 02 2020
16 02 2020
Historique:
entrez:
19
2
2020
pubmed:
19
2
2020
medline:
16
2
2021
Statut:
epublish
Résumé
The effects of hypercapnia on regional cerebral oxygen saturation (rSO A prospective, randomised, controlled trial in adult participants undergoing elective major surgery. A single tertiary centre in Heidelberg, Victoria, Australia. 40 participants were randomised to either a TMH or TN group (20 to each). TMH (partial pressure of carbon dioxide in arterial blood, PaCO The primary endpoint was the absolute difference between the two groups in percentage change in rSO The absolute difference between the two groups in percentage change in rSO TMH was associated with a stable increase in rSO The Australian New Zealand Clinical Trials Registry (ACTRN12616000320459).
Identifiants
pubmed: 32066598
pii: bmjopen-2019-029159
doi: 10.1136/bmjopen-2019-029159
pmc: PMC7045198
doi:
Substances chimiques
Carbon Dioxide
142M471B3J
Oxygen
S88TT14065
Banques de données
ANZCTR
['ACTRN12616000320459']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e029159Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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