Genomic influences on self-reported childhood maltreatment.

Child Child Abuse Forkhead Transcription Factors Genetic Predisposition to Disease Genome-Wide Association Study Genomics Humans Repressor Proteins Self Report Stress Disorders, Post-Traumatic

Journal

Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664

Informations de publication

Date de publication:
27 01 2020
Historique:
received: 03 08 2019
accepted: 11 12 2019
revised: 28 11 2019
entrez: 19 2 2020
pubmed: 19 2 2020
medline: 22 6 2021
Statut: epublish

Résumé

Childhood maltreatment is highly prevalent and serves as a risk factor for mental and physical disorders. Self-reported childhood maltreatment appears heritable, but the specific genetic influences on this phenotype are largely unknown. The aims of this study were to (1) identify genetic variation associated with self-reported childhood maltreatment, (2) estimate SNP-based heritability (h

Identifiants

DOI: 10.1038/s41398-020-0706-0 PMID: 32066696 PMC: PMC7026037
pubmed: 32066696
doi: 10.1038/s41398-020-0706-0
pii: 10.1038/s41398-020-0706-0
pmc: PMC7026037
doi:

Substances chimiques

FOXP1 protein, human 0
Forkhead Transcription Factors 0
Repressor Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

38

Subventions

Organisme : NICHD NIH HHS
ID : R01 HD102974
Pays : United States
Organisme : U.S. Department of Defense (United States Department of Defense)
ID : W911NF-09-1-0298
Pays : International
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : R21MH112956
Pays : International
Organisme : NIMH NIH HHS
ID : T32 MH017119
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH109539
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH106595
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : R01MH106595
Pays : International
Organisme : U.S. Department of Health & Human Services | NIH | Center for Scientific Review (NIH Center for Scientific Review)
ID : HD049907
Pays : International
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : F32MH109274
Pays : International
Organisme : U.S. Department of Health & Human Services | NIH | Center for Scientific Review (NIH Center for Scientific Review)
ID : MH085436
Pays : International
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : U01MH087981
Pays : International
Organisme : U.S. Department of Defense (United States Department of Defense)
ID : W81XWH-09-2-0044
Pays : International

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Auteurs

Shareefa Dalvie (S)

SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa. s.dalvie1@uct.ac.za.
ORCID: 0000-0003-2333-4823

Adam X Maihofer (AX)

Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego, CA, USA.
Veterans Affairs San Diego Healthcare System, Research Service, San Diego, CA, USA.
ORCID: 0000-0003-4517-1623

Jonathan R I Coleman (JRI)

King's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
King's College London, NIHR BRC at the Maudsley, London, UK.
ORCID: 0000-0002-6759-0944

Bekh Bradley (B)

Atlanta VA Health Care System, Mental Health Service Line, Decatur, GA, USA.
Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.

Gerome Breen (G)

King's College London, Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, London, UK.
King's College London, NIHR BRC at the Maudsley, London, UK.

Leslie A Brick (LA)

Alpert Medical School of Brown University, Providence, RI, USA.

Chia-Yen Chen (CY)

Massachusetts General Hospital, Analytic and Translational Genetics Unit, Boston, MA, USA.
Massachusetts General Hospital, Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Boston, MA, USA.
Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.
ORCID: 0000-0001-9548-5597

Karmel W Choi (KW)

Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.
Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA.
Massachusetts General Hospital, Department of Psychiatry, Boston, MA, USA.

Laramie E Duncan (LE)

Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
ORCID: 0000-0003-1131-661X

Guia Guffanti (G)

Harvard Medical School, Department of Psychiatry, Boston, MA, USA.
McLean Hospital, Belmont, MA, USA.

Magali Haas (M)

Cohen Veterans Bioscience, Cambridge, MA, USA.
ORCID: 0000-0002-6611-2449

Supriya Harnal (S)

Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.

Israel Liberzon (I)

Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI, USA.

Nicole R Nugent (NR)

Alpert Medical School of Brown University, Providence, RI, USA.
Bradley/Hasbro Children's Research Center of Rhode Island Hospital, Providence, RI, USA.

Allison C Provost (AC)

Cohen Veterans Bioscience, Cambridge, MA, USA.

Kerry J Ressler (KJ)

Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA.
Harvard Medical School, Department of Psychiatry, Boston, MA, USA.
McLean Hospital, Belmont, MA, USA.

Katy Torres (K)

Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego, CA, USA.
Veterans Affairs San Diego Healthcare System, Research Service, San Diego, CA, USA.
ORCID: 0000-0003-4201-0349

Ananda B Amstadter (AB)

Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Richmond, VA, USA.

S Bryn Austin (S)

Harvard Medical School, Department of Psychiatry, Boston, MA, USA.
Harvard School of Public Health, Department of Social and Behavioral Sciences, Boston, MA, USA.
Boston Children's Hospital, Division of Adolescent and Young Adult Medicine, Boston, MA, USA.
Brigham and Women's Hospital, Channing Division of Network Medicine, Boston, MA, USA.

Dewleen G Baker (DG)

Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego, CA, USA.
Veterans Affairs San Diego Healthcare System, Psychiatry Service, San Diego, CA, USA.
ORCID: 0000-0002-1736-9838

Elizabeth A Bolger (EA)

Harvard Medical School, Department of Psychiatry, Boston, MA, USA.
McLean Hospital, Belmont, MA, USA.

Richard A Bryant (RA)

Department of Psychology, University of New South Wales, Sydney, NSW, Australia.
ORCID: 0000-0002-9607-819X

Joseph R Calabrese (JR)

Department of Psychiatry, University Hospitals, Cleveland, OH, USA.

Douglas L Delahanty (DL)

Department of Psychological Sciences, Kent State University, Kent, OH, USA.
Research and Sponsored Programs, Kent State University, Kent, OH, USA.

Lindsay A Farrer (LA)

Department of Medicine, Boston University School of Medicine, Boston, MA, USA.

Norah C Feeny (NC)

Department of Psychological Sciences, Case Western Reserve University, Cleveland, OH, USA.
ORCID: 0000-0001-8590-4591

Janine D Flory (JD)

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

David Forbes (D)

Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia.

Sandro Galea (S)

Department of Psychological and Brain Sciences, Boston University, Boston, MA, USA.

Aarti Gautam (A)

US Army Medical Research and Materiel Command, Fort Detrick, MD, USA.

Joel Gelernter (J)

US Department of Veterans Affairs, Department of Psychiatry, West Haven, CT, USA.
VA Connecticut Healthcare Center, West Haven, CT, USA.
Department of Genetics and Neuroscience, Yale University School of Medicine, New Haven, CT, USA.
ORCID: 0000-0002-4067-1859

Rasha Hammamieh (R)

US Army Medical Research and Materiel Command, USACEHR, Fort Detrick, MD, USA.

Marti Jett (M)

US Army Medical Research and Materiel Command, USACEHR, Fort Detrick, MD, USA.
ORCID: 0000-0002-2899-0216

Angela G Junglen (AG)

Department of Psychological Sciences, Kent State University, Kent, OH, USA.

Milissa L Kaufman (ML)

Harvard Medical School, Department of Psychiatry, Boston, MA, USA.
McLean Hospital, Belmont, MA, USA.

Ronald C Kessler (RC)

Harvard Medical School, Department of Health Care Policy, Boston, MA, USA.
ORCID: 0000-0003-4831-2305

Alaptagin Khan (A)

McLean Hospital, Belmont, MA, USA.
Harvard Medical School, Department of Health Care Policy, Boston, MA, USA.

Henry R Kranzler (HR)

Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Mental Illness Research, Education and Clinical Center, Crescenz VAMC, Philadelphia, PA, USA.

Lauren A M Lebois (LAM)

Harvard Medical School, Department of Psychiatry, Boston, MA, USA.
McLean Hospital, Belmont, MA, USA.
ORCID: 0000-0001-5816-9181

Charles Marmar (C)

Department of Psychiatry, New York University School of Medicine, New York, NY, USA.

Matig R Mavissakalian (MR)

Department of Psychiatry, University Hospitals, Cleveland, OH, USA.

Alexander McFarlane (A)

University of Adelaide, Centre for Traumatic Stress Studies, Adelaide, SA, Australia.

Meaghan O' Donnell (MO)

Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia.

Holly K Orcutt (HK)

Department of Psychology, Northern Illinois University, DeKalb, IL, USA.

Robert H Pietrzak (RH)

U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, West Haven, CT, USA.
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

Victoria B Risbrough (VB)

Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego, CA, USA.
Veterans Affairs San Diego Healthcare System, Research Service, San Diego, CA, USA.
ORCID: 0000-0001-8347-3820

Andrea L Roberts (AL)

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
ORCID: 0000-0001-5023-4399

Alex O Rothbaum (AO)

Department of Psychological Sciences, Case Western Reserve University, Cleveland, OH, USA.

Peter Roy-Byrne (P)

Department of Psychiatry, University of Washington, Seattle, WA, USA.

Ken Ruggiero (K)

Department of Nursing and Department of Psychiatry, Medical University of South Carolina, Charleston, SC, USA.

Antonia V Seligowski (AV)

Harvard Medical School, Department of Psychiatry, Boston, MA, USA.
McLean Hospital, Belmont, MA, USA.

Christina M Sheerin (CM)

Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Richmond, VA, USA.
ORCID: 0000-0003-3773-641X

Derrick Silove (D)

Department of Psychiatry, University of New South Wales, Sydney, NSW, Australia.

Jordan W Smoller (JW)

Massachusetts General Hospital, Analytic and Translational Genetics Unit, Boston, MA, USA.
Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.
Massachusetts General Hospital, Department of Psychiatry, Boston, MA, USA.
ORCID: 0000-0002-0381-6334

Murray B Stein (MB)

Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Veterans Affairs San Diego Healthcare System, Psychiatry Service, San Diego, CA, USA.
Veterans Affairs San Diego Healthcare System, Million Veteran Program, San Diego, CA, USA.
ORCID: 0000-0001-9564-2871

Martin H Teicher (MH)

Harvard Medical School, Department of Psychiatry, Boston, MA, USA.
McLean Hospital, Belmont, MA, USA.

Robert J Ursano (RJ)

Department of Psychiatry, Uniformed Services University, Bethesda, MD, USA.

Miranda Van Hooff (M)

University of Adelaide, Centre for Traumatic Stress Studies, Adelaide, SA, Australia.

Sherry Winternitz (S)

Harvard Medical School, Department of Psychiatry, Boston, MA, USA.
McLean Hospital, Belmont, MA, USA.

Jonathan D Wolff (JD)

McLean Hospital, Belmont, MA, USA.

Rachel Yehuda (R)

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Mental Health, James J. Peters VA Medical Center, Bronx, NY, USA.

Hongyu Zhao (H)

Department of Biostatistics, Yale University, New Haven, CT, USA.

Lori A Zoellner (LA)

Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA.

Dan J Stein (DJ)

SA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
ORCID: 0000-0001-7218-7810

Karestan C Koenen (KC)

Massachusetts General Hospital, Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Boston, MA, USA.
Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USA.
Harvard School of Public Health, Department of Epidemiology, Boston, MA, USA.

Caroline M Nievergelt (CM)

Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Veterans Affairs San Diego Healthcare System, Center of Excellence for Stress and Mental Health, San Diego, CA, USA.
Veterans Affairs San Diego Healthcare System, Research Service, San Diego, CA, USA.
ORCID: 0000-0001-5766-8923

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Genomic influences on self-reported childhood...
questionsmedicales.fr › Sciences sociales › Sociologie › Problèmes sociaux › Violence › Violence domestique › Maltraitance des enfants › Genomic influences on self-reported childhood...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif hélice ailée › Facteurs de transcription Forkhead › Genomic influences on self-reported childhood...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Genomic influences on self-reported childhood...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Genomic influences on self-reported childhood...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Genomic influences on self-reported childhood...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genomic influences on self-reported childhood...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Genomic influences on self-reported childhood...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Autorapport › Genomic influences on self-reported childhood...
questionsmedicales.fr › Troubles mentaux › Troubles liés aux traumatismes et au stress › Troubles de stress traumatique › Troubles de stress post-traumatique › Genomic influences on self-reported childhood...