Spatiotemporal regulation of type I interferon expression determines the antiviral polarization of CD4
Adaptive Immunity
Adoptive Transfer
Animals
CD4-Positive T-Lymphocytes
/ classification
Cell Differentiation
/ immunology
Female
Interferon Type I
/ metabolism
Interleukin-6
/ biosynthesis
Lymphocytic choriomeningitis virus
/ immunology
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Spatio-Temporal Analysis
T-Lymphocytes, Helper-Inducer
/ immunology
Th1 Cells
/ immunology
Vesicular stomatitis Indiana virus
/ immunology
Vesicular stomatitis New Jersey virus
/ immunology
Journal
Nature immunology
ISSN: 1529-2916
Titre abrégé: Nat Immunol
Pays: United States
ID NLM: 100941354
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
09
04
2019
accepted:
10
01
2020
pubmed:
19
2
2020
medline:
21
4
2020
entrez:
19
2
2020
Statut:
ppublish
Résumé
Differentiation of CD4
Identifiants
pubmed: 32066949
doi: 10.1038/s41590-020-0596-6
pii: 10.1038/s41590-020-0596-6
pmc: PMC7043938
mid: EMS85430
doi:
Substances chimiques
Interferon Type I
0
Interleukin-6
0
interleukin-6, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
321-330Subventions
Organisme : European Research Council
ID : 281648
Pays : International
Organisme : European Research Council
ID : 725038
Pays : International
Commentaires et corrections
Type : CommentIn
Références
Hale, J. S. et al. Distinct memory CD4
pubmed: 23583644
pmcid: 3741679
doi: 10.1016/j.immuni.2013.02.020
Wu, T. et al. Cutting edge: miR-17-92 is required for both CD4 Th1 and T follicular helper cell responses during viral infection. J. Immunol. 195, 2515–2519 (2015).
pubmed: 26276869
doi: 10.4049/jimmunol.1500317
Crotty, S. Follicular helper CD4 T cells (T
pubmed: 21314428
doi: 10.1146/annurev-immunol-031210-101400
Vinuesa, C. G., Linterman, M. A., Yu, D. & MacLennan, I. C. Follicular helper T cells. Annu. Rev. Immunol. 34, 335–368 (2016).
pubmed: 26907215
doi: 10.1146/annurev-immunol-041015-055605
Szabo, S. J. et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100, 655–669 (2000).
pubmed: 10761931
doi: 10.1016/S0092-8674(00)80702-3
Arnaout, R. A. & Nowak, M. A. Competitive coexistence in antiviral immunity. J. Theor. Biol. 204, 431–441 (2000).
pubmed: 10816366
doi: 10.1006/jtbi.2000.2027
Hangartner, L., Zinkernagel, R. M. & Hengartner, H. Antiviral antibody responses: the two extremes of a wide spectrum. Nat. Rev. Immunol. 6, 231–243 (2006).
pubmed: 16498452
doi: 10.1038/nri1783
Kuka, M. & Iannacone, M. Viral subversion of B cell responses within secondary lymphoid organs. Nat. Rev. Immunol. 18, 255–265 (2018).
pubmed: 29249807
doi: 10.1038/nri.2017.133
Maloy, K. J. et al. Qualitative and quantitative requirements for CD4
pubmed: 10072535
Oxenius, A., Bachmann, M. F., Zinkernagel, R. M. & Hengartner, H. Virus-specific MHC-class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection. Eur. J. Immunol. 28, 390–400 (1998).
pubmed: 9485218
doi: 10.1002/(SICI)1521-4141(199801)28:01<390::AID-IMMU390>3.0.CO;2-O
Fazilleau, N., McHeyzer-Williams, L. J., Rosen, H. & McHeyzer-Williams, M. G. The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding. Nat. Immunol. 10, 375–384 (2009).
pubmed: 19252493
pmcid: 2712297
doi: 10.1038/ni.1704
Fallet, B. et al. Interferon-driven deletion of antiviral B cells at the onset of chronic infection. Sci. Immunol. 1, eaah6817 (2016).
pubmed: 27872905
pmcid: 5115616
doi: 10.1126/sciimmunol.aah6817
Osokine, I. et al. Type I interferon suppresses de novo virus-specific CD4 Th1 immunity during an established persistent viral infection. Proc. Natl Acad. Sci. USA 111, 7409–7414 (2014).
pubmed: 24799699
pmcid: 4034239
doi: 10.1073/pnas.1401662111
Kerfoot, S. M. et al. Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone. Immunity 34, 947–960 (2011).
pubmed: 21636295
pmcid: 3280079
doi: 10.1016/j.immuni.2011.03.024
Mempel, T. R., Henrickson, S. E. & Von Andrian, U. H. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427, 154–159 (2004).
pubmed: 14712275
doi: 10.1038/nature02238
Gerner, M. Y., Casey, K. A., Kastenmuller, W. & Germain, R. N. Dendritic cell and antigen dispersal landscapes regulate T cell immunity. J. Exp. Med. 214, 3105–3122 (2017).
pubmed: 28847868
pmcid: 5626399
doi: 10.1084/jem.20170335
Groom, J. R. et al. CXCR3 chemokine receptor–ligand interactions in the lymph node optimize CD4
pubmed: 23123063
pmcid: 3525757
doi: 10.1016/j.immuni.2012.08.016
Medaglia, C. et al. Spatial reconstruction of immune niches by combining photoactivatable reporters and scRNA-seq. Science 358, 1622–1626 (2017).
pubmed: 29217582
pmcid: 7234837
doi: 10.1126/science.aao4277
Victora, G. D. et al. Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell 143, 592–605 (2010).
pubmed: 21074050
pmcid: 3035939
doi: 10.1016/j.cell.2010.10.032
Hangartner, L. et al. Antiviral immune responses in gene-targeted mice expressing the immunoglobulin heavy chain of virus-neutralizing antibodies. Proc. Natl Acad. Sci. USA 100, 12883–12888 (2003).
pubmed: 14569006
pmcid: 240713
doi: 10.1073/pnas.2135542100
Cook, K. D., Kline, H. C. & Whitmire, J. K. NK cells inhibit humoral immunity by reducing the abundance of CD4
pubmed: 25986014
pmcid: 4763952
doi: 10.1189/jlb.4HI1214-594R
Narni-Mancinelli, E. et al. Fate mapping analysis of lymphoid cells expressing the NKp46 cell surface receptor. Proc. Natl Acad. Sci. USA 108, 18324–18329 (2011).
pubmed: 22021440
pmcid: 3215049
doi: 10.1073/pnas.1112064108
Buch, T. et al. A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration. Nat. Methods 2, 419–426 (2005).
pubmed: 15908920
doi: 10.1038/nmeth762
Odermatt, B., Eppler, M., Leist, T. P., Hengartner, H. & Zinkernagel, R. M. Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure. Proc. Natl Acad. Sci. USA 88, 8252–8256 (1991).
pubmed: 1910175
pmcid: 52485
doi: 10.1073/pnas.88.18.8252
Borrow, P., Evans, C. F. & Oldstone, M. B. Virus-induced immunosuppression: immune system-mediated destruction of virus-infected dendritic cells results in generalized immune suppression. J. Virol. 69, 1059–1070 (1995).
pubmed: 7815484
pmcid: 188677
doi: 10.1128/jvi.69.2.1059-1070.1995
Moseman, E. A., Wu, T., de la Torre, J. C., Schwartzberg, P. L. & McGavern, D. B. Type I interferon suppresses virus-specific B cell responses by modulating CD8
pubmed: 27812556
pmcid: 5089817
doi: 10.1126/sciimmunol.aah3565
Isogawa, M., Chung, J., Murata, Y., Kakimi, K. & Chisari, F. V. CD40 activation rescues antiviral CD8
pubmed: 23853599
pmcid: 3708877
doi: 10.1371/journal.ppat.1003490
Sammicheli, S. et al. Inflammatory monocytes hinder antiviral B cell responses. Sci. Immunol. 1, eaah6789 (2016).
pubmed: 27868108
pmcid: 5111729
doi: 10.1126/sciimmunol.aah6789
Boring, L. et al. Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice. J. Clin. Invest. 100, 2552–2561 (1997).
pubmed: 9366570
pmcid: 508456
doi: 10.1172/JCI119798
Eisenbarth, S. C. Dendritic cell subsets in T cell programming: location dictates function. Nat. Rev. Immunol. 19, 89–103 (2018).
doi: 10.1038/s41577-018-0088-1
Li, J., Lu, E., Yi, T. & Cyster, J. G. EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells. Nature 533, 110–114 (2016).
pubmed: 27147029
pmcid: 4883664
doi: 10.1038/nature17947
Kuka, M., De Giovanni, M. & Iannacone, M. The role of type I interferons in CD4
Nurieva, R. I. et al. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 29, 138–149 (2008).
pubmed: 18599325
pmcid: 2556461
doi: 10.1016/j.immuni.2008.05.009
Eto, D. et al. IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation. PLoS One 6, e17739 (2011).
pubmed: 21423809
pmcid: 3056724
doi: 10.1371/journal.pone.0017739
Cucak, H., Yrlid, U., Reizis, B., Kalinke, U. & Johansson-Lindbom, B. Type I interferon signalling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells. Immunity 31, 491–501 (2009).
pubmed: 19733096
doi: 10.1016/j.immuni.2009.07.005
Baran, Y. et al. MetaCell: analysis of single-cell RNA-seq data using K-nn graph partitions. Genome Biol. 20, 206 (2019).
pubmed: 31604482
pmcid: 6790056
doi: 10.1186/s13059-019-1812-2
Chakarov, S. & Fazilleau, N. Monocyte-derived dendritic cells promote T follicular helper cell differentiation. EMBO Mol. Med. 6, 590–603 (2014).
pubmed: 24737871
pmcid: 4023883
doi: 10.1002/emmm.201403841
Scheu, S., Dresing, P. & Locksley, R. M. Visualization of IFNβ production by plasmacytoid versus conventional dendritic cells under specific stimulation conditions in vivo. Proc. Natl Acad. Sci. USA 105, 20416–20421 (2008).
pubmed: 19088190
pmcid: 2629269
doi: 10.1073/pnas.0808537105
Kumagai, Y. et al. Alveolar macrophages are the primary interferon-α producer in pulmonary infection with RNA viruses. Immunity 27, 240–252 (2007).
pubmed: 17723216
doi: 10.1016/j.immuni.2007.07.013
Iannacone, M. et al. Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus. Nature 465, 1079–1083 (2010).
pubmed: 20577213
pmcid: 2892812
doi: 10.1038/nature09118
Trinchieri, G. Lymphocyte choriomeningitis virus plays hide-and-seek with type 1 interferon. Cell Host Microbe 11, 553–555 (2012).
pubmed: 22704613
doi: 10.1016/j.chom.2012.05.007
Gaya, M. et al. Inflammation-induced disruption of SCS macrophages impairs B cell responses to secondary infection. Science 347, 667–672 (2015).
pubmed: 25657250
doi: 10.1126/science.aaa1300
Kawano, Y., Noma, T., Kou, K., Yoshizawa, I. & Yata, J. Regulation of human IgG subclass production by cytokines: human IgG subclass production enhanced differentially by interleukin-6. Immunology 84, 278–284 (1995).
pubmed: 7751005
pmcid: 1415106
Hsieh, C. S. et al. Development of T
pubmed: 8097338
doi: 10.1126/science.8097338
Bradley, L. M., Dalton, D. K. & Croft, M. A direct role for IFN-γ in regulation of Th1 cell development. J. Immunol. 157, 1350–1358 (1996).
pubmed: 8759714
Heufler, C. et al. Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-γ production by T helper 1 cells. Eur. J. Immunol. 26, 659–668 (1996).
pubmed: 8605935
doi: 10.1002/eji.1830260323
Oxenius, A., Karrer, U., Zinkernagel, R. M. & Hengartner, H. IL-12 is not required for induction of type 1 cytokine responses in viral infections. J. Immunol. 162, 965–973 (1999).
pubmed: 9916721
Schijns, V. E. et al. Mice lacking IL-12 develop polarized Th1 cells during viral infection. J. Immunol. 160, 3958–3964 (1998).
pubmed: 9558103
Madisen, L. et al. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat. Neurosci. 13, 133–140 (2010).
pubmed: 20023653
doi: 10.1038/nn.2467
Pircher, H., Bürki, K., Lang, R., Hengartner, H. & Zinkernagel, R. M. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature 342, 559–561 (1989).
pubmed: 2573841
doi: 10.1038/342559a0
Müller, U. et al. Functional role of type I and type II interferons in antiviral defense. Science 264, 1918–1921 (1994).
pubmed: 8009221
doi: 10.1126/science.8009221
Yamazaki, C. et al. Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR1. J. Immunol. 190, 6071–6082 (2013).
pubmed: 23670193
doi: 10.4049/jimmunol.1202798
Caton, M. L., Smith-Raska, M. R. & Reizis, B. Notch–RBP-J signalling controls the homeostasis of CD8
pubmed: 17591855
pmcid: 2118632
doi: 10.1084/jem.20062648
Prigge, J. R. et al. Type I IFNs act upon hematopoietic progenitors to protect and maintain hematopoiesis during Pneumocystis lung infection in mice. J. Immunol. 195, 5347–5357 (2015).
pubmed: 26519535
doi: 10.4049/jimmunol.1501553
Jung, S. et al. Analysis of fractalkine receptor CX
pubmed: 10805752
pmcid: 85780
doi: 10.1128/MCB.20.11.4106-4114.2000
Saederup, N. et al. Selective chemokine receptor usage by central nervous system myeloid cells in CCR2-red fluorescent protein knock-in mice. PLoS One 5, e13693 (2010).
pubmed: 21060874
pmcid: 2965160
doi: 10.1371/journal.pone.0013693
Eschli, B. et al. Early antibodies specific for the neutralizing epitope on the receptor binding subunit of the lymphocytic choriomeningitis virus glycoprotein fail to neutralize the virus. J. Virol. 81, 11650–11657 (2007).
pubmed: 17699567
pmcid: 2168768
doi: 10.1128/JVI.00955-07
Tonti, E. et al. Bisphosphonates target B cells to enhance humoral immune responses. Cell Rep. 5, 323–330 (2013).
pubmed: 24120862
doi: 10.1016/j.celrep.2013.09.004
Hor, J. L. et al. Spatiotemporally distinct interactions with dendritic cell subsets facilitates CD4
pubmed: 26297566
doi: 10.1016/j.immuni.2015.07.020
Sammicheli, S., Kuka, M. & Iannacone, M. Intravital imaging of B cell responses in lymph nodes. Methods Mol. Biol. 1763, 63–74 (2018).
pubmed: 29476489
doi: 10.1007/978-1-4939-7762-8_7
Tan, Y. et al. Streamlining volumetric multi-channel image cytometry using hue-saturation-brightness-based surface creation. Commun. Biol. 1, 136 (2018).
pubmed: 30272015
pmcid: 6127105
doi: 10.1038/s42003-018-0139-y
Jaitin, D. A. et al. Massively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types. Science 343, 776–779 (2014).
pubmed: 24531970
pmcid: 4412462
doi: 10.1126/science.1247651