Paraventricular nucleus CRH neurons encode stress controllability and regulate defensive behavior selection.
Accelerometry
Animals
Anticipation, Psychological
/ physiology
Corticotropin-Releasing Hormone
/ physiology
Cues
Electrophysiological Phenomena
Escape Reaction
/ physiology
Hindlimb Suspension
Male
Mice
Mice, Inbred C57BL
Neurons
/ physiology
Optogenetics
Paraventricular Hypothalamic Nucleus
/ cytology
Photic Stimulation
Stress, Psychological
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
08
02
2019
accepted:
14
01
2020
pubmed:
19
2
2020
medline:
14
4
2020
entrez:
19
2
2020
Statut:
ppublish
Résumé
In humans and rodents, the perception of control during stressful events has lasting behavioral consequences. These consequences are apparent even in situations that are distinct from the stress context, but how the brain links prior stressful experience to subsequent behaviors remains poorly understood. By assessing innate defensive behavior in a looming-shadow task, we show that the initiation of an escape response is preceded by an increase in the activity of corticotropin-releasing hormone (CRH) neurons in the paraventricular nucleus (PVN) of the hypothalamus (CRH
Identifiants
pubmed: 32066984
doi: 10.1038/s41593-020-0591-0
pii: 10.1038/s41593-020-0591-0
doi:
Substances chimiques
Corticotropin-Releasing Hormone
9015-71-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
398-410Subventions
Organisme : CIHR
ID : FDN-148440
Pays : Canada
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