Paracrine signaling in islet function and survival.
Animals
Cell Survival
Ghrelin
/ metabolism
Glucagon-Secreting Cells
/ metabolism
Glucose
/ metabolism
Glycogen
/ metabolism
Humans
Insulin
/ metabolism
Insulin-Secreting Cells
/ metabolism
Islets of Langerhans
/ cytology
Pancreatic Polypeptide
/ metabolism
Paracrine Communication
Signal Transduction
Somatostatin
/ metabolism
Somatostatin-Secreting Cells
/ metabolism
Diabetes
Islet biology
Islet function
Paracrine signaling
Survival
Journal
Journal of molecular medicine (Berlin, Germany)
ISSN: 1432-1440
Titre abrégé: J Mol Med (Berl)
Pays: Germany
ID NLM: 9504370
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
20
08
2019
accepted:
11
02
2020
revised:
05
02
2020
pubmed:
19
2
2020
medline:
16
6
2021
entrez:
19
2
2020
Statut:
ppublish
Résumé
The pancreatic islet is a dense cellular network comprised of several cell types with endocrine function vital in the control of glucose homeostasis, metabolism, and feeding behavior. Within the islet, endocrine hormones also form an intricate paracrine network with supportive cells (endothelial, neuronal, immune) and secondary signaling molecules regulating cellular function and survival. Modulation of these signals has potential consequences for diabetes development, progression, and therapeutic intervention. Beta cell loss, reduced endogenous insulin secretion, and dysregulated glucagon secretion are hallmark features of both type 1 and 2 diabetes that not only impact systemic regulation of glucose, but also contribute to the function and survival of cells within the islet. Advancing research and technology have revealed new islet biology (cellular identity and transcriptomes) and identified previously unrecognized paracrine signals and mechanisms (somatostatin and ghrelin paracrine actions), while shifting prior views of intraislet communication. This review will summarize the paracrine signals regulating islet endocrine function and survival, the disruption and dysfunction that occur in diabetes, and potential therapeutic targets to preserve beta cell mass and function.
Identifiants
pubmed: 32067063
doi: 10.1007/s00109-020-01887-x
pii: 10.1007/s00109-020-01887-x
pmc: PMC7899133
mid: NIHMS1571236
doi:
Substances chimiques
Ghrelin
0
Insulin
0
Somatostatin
51110-01-1
Pancreatic Polypeptide
59763-91-6
Glycogen
9005-79-2
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
451-467Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK114356
Pays : United States
Commentaires et corrections
Type : ErratumIn
Références
N Engl J Med. 2019 Aug 15;381(7):603-613
pubmed: 31180194
J Biol Chem. 2003 Dec 26;278(52):52446-53
pubmed: 14565957
Cell Metab. 2006 Jan;3(1):47-58
pubmed: 16399504
Mol Endocrinol. 2012 Jul;26(7):1225-34
pubmed: 22669743
J Physiol. 2018 Jan 15;596(2):197-215
pubmed: 28975620
Mol Metab. 2016 Aug 26;5(10):988-996
pubmed: 27689011
J Physiol. 2000 Dec 15;529 Pt 3:723-34
pubmed: 11118501
PLoS One. 2011 Jan 25;6(1):e16096
pubmed: 21283589
Diabetes. 2012 Jan;61(1):74-84
pubmed: 22187375
J Clin Invest. 1984 Dec;74(6):2296-9
pubmed: 6392344
Endocrinology. 1985 Sep;117(3):824-33
pubmed: 2862021
Cell Metab. 2016 Jan 12;23(1):179-93
pubmed: 26626461
Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8641-5
pubmed: 1326760
J Clin Endocrinol Metab. 2000 Nov;85(11):4053-9
pubmed: 11095432
Endocrinology. 2015 Jul;156(7):2365-7
pubmed: 26091426
Diabetes Care. 2003 Jun;26(6):1902-12
pubmed: 12766131
J Physiol. 1999 May 15;517 ( Pt 1):85-93
pubmed: 10226151
J Mol Endocrinol. 2018 Jul;61(1):R43-R60
pubmed: 29661799
Diabetes. 2010 Nov;59(11):2697-707
pubmed: 20705776
Nat Rev Endocrinol. 2018 Jul;14(7):404-414
pubmed: 29773871
J Biol Chem. 2006 Sep 8;281(36):25869-74
pubmed: 16831875
Diabetes. 2019 Jun;68(6):1267-1276
pubmed: 30967424
Diabetologia. 2000 Apr;43(4):393-410
pubmed: 10819232
J Histochem Cytochem. 2015 Aug;63(8):575-91
pubmed: 26216135
Nature. 2010 Apr 22;464(7292):1149-54
pubmed: 20364121
FASEB J. 2019 Mar;33(3):3968-3984
pubmed: 30509117
Science. 1973 Oct 12;182(4108):171-3
pubmed: 4581053
Diabetologia. 2000 Aug;43(8):1012-9
pubmed: 10990079
Diabetologia. 2015 Mar;58(3):558-65
pubmed: 25500700
Diabetes. 2010 Jul;59(7):1694-701
pubmed: 20413510
Diabetologia. 2012 Dec;55(12):3262-72
pubmed: 22965295
Am J Physiol. 1997 May;272(5 Pt 1):E769-74
pubmed: 9176174
Endocrinology. 2006 May;147(5):2346-56
pubmed: 16484329
Nat Genet. 2006 May;38(5):583-8
pubmed: 16642022
Physiol Rev. 2015 Apr;95(2):513-48
pubmed: 25834231
Nat Med. 2015 May;21(5):512-7
pubmed: 25894829
Cell Death Dis. 2018 Jun 7;9(6):682
pubmed: 29880854
Horm Metab Res. 2015 Jan;47(1):56-63
pubmed: 25350519
Nat Genet. 2002 May;31(1):111-5
pubmed: 11923875
Cell Metab. 2008 Jun;7(6):545-54
pubmed: 18522835
Nature. 1989 Sep 21;341(6239):233-6
pubmed: 2550826
Nat Rev Endocrinol. 2018 Dec;14(12):694-704
pubmed: 30310153
Diabetes. 2020 Apr;69(4):550-558
pubmed: 31882565
Diabetes Care. 2014 Jun;37(6):1741-4
pubmed: 24696460
Physiol Rev. 2018 Jan 1;98(1):117-214
pubmed: 29212789
PLoS Genet. 2013;9(1):e1003274
pubmed: 23382704
Science. 1974 Apr 26;184(4135):482-4
pubmed: 4594711
Diabetes Care. 2015 Feb;38(2):323-8
pubmed: 25519449
Cell Syst. 2016 Oct 26;3(4):346-360.e4
pubmed: 27667365
Diabetes. 2014 Jan;63(1):216-23
pubmed: 24089510
Nat Commun. 2019 Jan 11;10(1):139
pubmed: 30635569
Diabetes. 1998 Jan;47(1):66-72
pubmed: 9421376
J Clin Invest. 1987 Nov;80(5):1455-8
pubmed: 2890658
Diabetologia. 2017 Sep;60(9):1731-1739
pubmed: 28551699
Mol Metab. 2017 Jul 18;6(9):1010-1023
pubmed: 28951825
Mol Endocrinol. 2005 Jan;19(1):198-212
pubmed: 15459251
Life Sci. 1995;57(13):1249-65
pubmed: 7674817
Cell Metab. 2018 Nov 6;28(5):787-792.e3
pubmed: 30057067
Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E695-707
pubmed: 19602585
Diabetologia. 2012 Jul;55(7):1995-2004
pubmed: 22526610
Cell Metab. 2010 Jun 9;11(6):543-553
pubmed: 20519125
Endocrinology. 2004 Jun;145(6):2653-9
pubmed: 15044356
Endocrinology. 2003 Jul;144(7):3216-24
pubmed: 12810578
Endocr Rev. 2008 May;29(3):292-302
pubmed: 18292467
Endocrinology. 2017 Jun 1;158(6):1701-1714
pubmed: 28323942
Diabetes Care. 2016 Jul;39(7):1241-9
pubmed: 26681715
Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11692-7
pubmed: 21709230
Endocrinology. 1980 Dec;107(6):2127-9
pubmed: 6107246
J Clin Invest. 1987 Jan;79(1):20-4
pubmed: 2878938
Cell Metab. 2006 Nov;4(5):391-406
pubmed: 17084712
Diabetes. 2005 Jun;54(6):1789-97
pubmed: 15919801
Am J Physiol Regul Integr Comp Physiol. 2015 Oct;309(7):R788-94
pubmed: 26202070
Mol Metab. 2017 May 05;6(9):991-1001
pubmed: 28951823
Diabetes. 2007 Apr;56(4):1107-12
pubmed: 17317764
Biochim Biophys Acta. 2015 Feb;1850(2):343-51
pubmed: 25445712
J Clin Invest. 2002 Oct;110(7):1011-9
pubmed: 12370279
Diabetes. 2006 May;55(5):1190-6
pubmed: 16644672
Diabetes. 1999 Jan;48(1):77-85
pubmed: 9892225
Cell. 1999 Feb 5;96(3):329-39
pubmed: 10025399
Diabetes. 2007 Feb;56(2):320-7
pubmed: 17259375
Diabetes Care. 2016 Jul;39(7):1075-7
pubmed: 27330122
Lancet. 1965 Aug 28;2(7409):415-6
pubmed: 14346763
J Clin Invest. 2008 Nov;118(11):3790-7
pubmed: 18846254
Endocrinology. 1996 Feb;137(2):693-7
pubmed: 8593819
Cell Metab. 2017 May 2;25(5):1160-1175.e11
pubmed: 28467932
Diabetes. 2014 Aug;63(8):2714-26
pubmed: 24658304
Diabetologia. 2007 Jan;50(1):142-50
pubmed: 17131145
Am J Physiol Endocrinol Metab. 2004 Jan;286(1):E41-9
pubmed: 14519599
Cell Metab. 2006 Jun;3(6):449-61
pubmed: 16753580
Diabetes. 2010 Nov;59(11):2936-40
pubmed: 20811038
Cell Tissue Res. 2003 Oct;314(1):33-42
pubmed: 12898210
Cell Metab. 2014 Dec 2;20(6):979-90
pubmed: 25470546
Diabetes. 2013 Dec;62(12):4154-64
pubmed: 23884891
Endocrinology. 1981 Jul;109(1):279-83
pubmed: 6113132
J Biol Chem. 1948 Sep;175(2):663-74
pubmed: 18880761
Diabetologia. 2004 May;47(5):806-15
pubmed: 15095038
Endocr Rev. 2007 Feb;28(1):84-116
pubmed: 17261637
Metabolism. 1978 Sep;27(9 Suppl 1):1299-302
pubmed: 210359
Biochim Biophys Acta Gen Subj. 2017 Apr;1861(4):749-758
pubmed: 28069397
Diabetes. 2009 Sep;58(9):2070-83
pubmed: 19542200
Nature. 2019 Mar;567(7746):43-48
pubmed: 30760930
Regul Pept. 2002 Jul 15;107(1-3):63-9
pubmed: 12137967
Mol Cell. 1998 May;1(6):933-8
pubmed: 9660977
Physiol Rev. 2017 Apr;97(2):721-766
pubmed: 28275047
Diabetes. 2006 Dec;55(12):3486-93
pubmed: 17130496
Cell Metab. 2014 Oct 7;20(4):573-91
pubmed: 25242225
J Clin Invest. 1977 Sep;60(3):760-5
pubmed: 330567
Nat Cell Biol. 2018 Nov;20(11):1267-1277
pubmed: 30361701
Proc Natl Acad Sci U S A. 1977 May;74(5):2140-3
pubmed: 325567
Nat Med. 2015 Jul;21(7):769-76
pubmed: 26076035
Diabetes. 2019 Jun;68(6):1230-1239
pubmed: 30936150
J Clin Invest. 1988 Jul;82(1):350-3
pubmed: 2455737
Cell. 1993 Oct 8;75(1):59-72
pubmed: 8402901
Cell. 2017 Jan 12;168(1-2):73-85.e11
pubmed: 27916274
Diabetes. 2018 Sep;67(9):1783-1794
pubmed: 29950394
Diabetes. 2002 Apr;51(4):958-65
pubmed: 11916913
Metabolism. 1978 Sep;27(9 Suppl 1):1223-6
pubmed: 682984
Trends Pharmacol Sci. 2013 Dec;34(12):676-88
pubmed: 24183675
J Clin Invest. 2015 Oct 1;125(10):3831-46
pubmed: 26389675
Nature. 2014 Oct 23;514(7523):503-7
pubmed: 25141178
PLoS One. 2013 Jun 24;8(6):e67454
pubmed: 23826303
Diabetes. 1976 Apr;25(4):275-82
pubmed: 131725
Diabetes. 2013 Apr;62(4):1196-205
pubmed: 23160527
Mol Metab. 2018 Nov;17:28-38
pubmed: 30170980
Nat Biotechnol. 2012 Feb 26;30(3):261-4
pubmed: 22371083
JAMA. 1975 Oct 13;234(2):159-5
pubmed: 1242153
Diabetes. 2014 Jul;63(7):2232-43
pubmed: 24931034
J Histochem Cytochem. 2004 Mar;52(3):391-400
pubmed: 14966206
Diabetologia. 2008 Dec;51(12):2263-70
pubmed: 18795252
Cell Metab. 2006 May;3(5):379-86
pubmed: 16679295
Pharmacol Ther. 2007 Mar;113(3):546-93
pubmed: 17306374
Mol Metab. 2016 May 03;5(7):449-458
pubmed: 27408771
Cell Metab. 2017 Mar 7;25(3):727-738
pubmed: 28190773
Cell Rep. 2017 Mar 28;18(13):3192-3203
pubmed: 28355570
Exp Biol Med (Maywood). 2010 Feb;235(2):189-98
pubmed: 20404034
Clin Endocrinol Metab. 1986 Feb;15(1):33-58
pubmed: 2869846
Vitam Horm. 2014;95:165-93
pubmed: 24559918
Islets. 2010 Nov-Dec;2(6):341-4
pubmed: 21099335
Nat Med. 2015 Jun;21(6):619-27
pubmed: 25985365
Cell Metab. 2017 Jun 6;25(6):1348-1361.e8
pubmed: 28591637
Diabetes. 1987 May;36(5):592-6
pubmed: 2883057
Endocrinology. 1996 Oct;137(10):4108-14
pubmed: 8828464
Cell Rep. 2015 Jul 21;12(3):495-510
pubmed: 26166562
Diabetologia. 1995 Mar;38(3):274-6
pubmed: 7758872
Diabetologia. 2019 Oct;62(10):1901-1914
pubmed: 31372667
Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):611-7
pubmed: 16385087
J Histochem Cytochem. 2005 Sep;53(9):1087-97
pubmed: 15923354
Diabetes. 1983 Feb;32(2):134-41
pubmed: 6337896
J Diabetes Res. 2019 Feb 26;2019:5783545
pubmed: 30937314
Diabetes. 1982 Oct;31(10):883-9
pubmed: 6759221
Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):16876-82
pubmed: 21949366
Diabetes. 2010 Dec;59(12):3090-8
pubmed: 20802254
Diabetes. 2003 May;52(5):1176-81
pubmed: 12716749
Mol Metab. 2019 Dec;30:72-130
pubmed: 31767182
Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1438-43
pubmed: 12552113
Diabetes. 2005 Jun;54(6):1808-15
pubmed: 15919803
Diabetes. 2014 Dec;63(12):4197-205
pubmed: 25008178
Diabetologia. 2016 Oct;59(10):2156-65
pubmed: 27390011
Cell Rep. 2018 Oct 30;25(5):1127-1134.e2
pubmed: 30380405
Diabetes. 2002 Mar;51(3):669-75
pubmed: 11872665
Diabetes. 1998 Aug;47(8):1243-52
pubmed: 9703324
Diabetes. 2004 Jun;53(6):1482-7
pubmed: 15161752
Am J Physiol Endocrinol Metab. 2019 Jul 1;317(1):E139-E146
pubmed: 31063397
Cell Metab. 2017 Apr 4;25(4):911-926.e6
pubmed: 28380380
Diabetes. 2004 Jun;53(6):1488-95
pubmed: 15161753
Endocrinology. 1983 Jan;112(1):220-5
pubmed: 6128222
Cell Metab. 2013 Jun 4;17(6):819-837
pubmed: 23684623
Diabetes. 2019 Mar;68(3):598-608
pubmed: 30552110
Neuron. 1996 Sep;17(3):513-22
pubmed: 8816714
Biochem Biophys Res Commun. 2002 Jan 18;290(2):839-43
pubmed: 11785978
Diabetes. 1995 Nov;44(11):1249-58
pubmed: 7589820
Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2888-93
pubmed: 25695968
Diabetologia. 2004 Mar;47(3):478-487
pubmed: 14762654
Cell Metab. 2009 Apr;9(4):350-61
pubmed: 19356716
Diabetes. 2019 Sep;68(9):1795-1805
pubmed: 31201280
Diabet Med. 1999 Jun;16(6):466-71
pubmed: 10391393
Lancet Diabetes Endocrinol. 2018 Nov;6(11):891-900
pubmed: 29699867
Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15498-503
pubmed: 26621734
Nat Med. 2011 Jun 19;17(7):888-92
pubmed: 21685896
Cell Metab. 2018 Jan 9;27(1):218-225.e4
pubmed: 29103923
Endocrinology. 2000 Jan;141(1):111-7
pubmed: 10614629
Cell Rep. 2018 Mar 6;22(10):2667-2676
pubmed: 29514095
Diabetes. 2009 Feb;58(2):403-11
pubmed: 18984743
Diabetes. 2004 Jan;53(1):5-13
pubmed: 14693691
Diabetologia. 1989 Mar;32(3):207-12
pubmed: 2568961
Cell Metab. 2016 Oct 11;24(4):593-607
pubmed: 27667667
Metabolism. 1980 Dec;29(12):1242-6
pubmed: 6109226
Diabetes. 2006 Apr;55(4):1051-6
pubmed: 16567528
Cell Metab. 2018 Mar 6;27(3):630-644.e4
pubmed: 29514070
J Biol Chem. 2003 Jan 3;278(1):471-8
pubmed: 12409292
Cell Metab. 2017 Jun 6;25(6):1362-1373.e5
pubmed: 28591638
J Biol Chem. 2014 Dec 26;289(52):36275-83
pubmed: 25391656
Proc Natl Acad Sci U S A. 1983 Jan;80(1):215-8
pubmed: 6130530
Ann N Y Acad Sci. 2018 Jan;1411(1):140-152
pubmed: 29377200
Cell Metab. 2016 Sep 13;24(3):389-401
pubmed: 27452146
J Proteome Res. 2013 Aug 2;12(8):3610-9
pubmed: 23746063
Diabetes. 2005 Feb;54(2):482-91
pubmed: 15677506
Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2753-2758
pubmed: 28115707
Am J Physiol Endocrinol Metab. 2015 Jan 15;308(2):E130-43
pubmed: 25406263
N Engl J Med. 1975 May 8;292(19):985-9
pubmed: 804137
Am J Physiol Endocrinol Metab. 2012 Nov 1;303(9):E1107-16
pubmed: 22932785
FEBS Lett. 2006 Dec 22;580(30):6977-80
pubmed: 17161395
Diabetes. 1988 Jan;37(1):81-8
pubmed: 3275557