HDL Subclass Analysis in Predicting Metabolic Syndrome in Koreans With High HDL Cholesterol Levels.
Cardiovascular risk
HDL3 cholesterol
High-density lipoprotein cholesterol
Metabolic syndrome
Subclass
Journal
Annals of laboratory medicine
ISSN: 2234-3814
Titre abrégé: Ann Lab Med
Pays: Korea (South)
ID NLM: 101571172
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
15
08
2019
revised:
26
11
2019
accepted:
22
01
2020
entrez:
19
2
2020
pubmed:
19
2
2020
medline:
23
12
2020
Statut:
ppublish
Résumé
High-density lipoprotein cholesterol (HDL-C) is a complex mixture of subclasses with heterogeneous atheroprotective activities. We analyzed HDL-C subclass in relation to cardiovascular risk and metabolic syndrome (MetS) in a population with high HDL-C levels. A total of 300 Korean individuals with high HDL-C levels (≥2.331 mmol/L) were enrolled following a comprehensive general medical examination including body composition analysis. HDL3-C levels were measured using the HDL3-EX SEIKEN kit (Randox Ltd., Crumlin, UK) and non-HDL3-C levels were calculated by subtracting HDL3-C levels from total HDL-C levels. HDL3-C levels and HDL3-C proportion had a weak positive correlation with low-density lipoprotein cholesterol (LDL-C) and triglycerides (r=0.21, r=0.25; r=0.26, r=0.34, respectively, all In populations with high HDL-C levels, HDL-C subclass may provide a greater amount of information on cardiovascular risk and MetS than HDL-C levels alone.
Sections du résumé
BACKGROUND
BACKGROUND
High-density lipoprotein cholesterol (HDL-C) is a complex mixture of subclasses with heterogeneous atheroprotective activities. We analyzed HDL-C subclass in relation to cardiovascular risk and metabolic syndrome (MetS) in a population with high HDL-C levels.
METHODS
METHODS
A total of 300 Korean individuals with high HDL-C levels (≥2.331 mmol/L) were enrolled following a comprehensive general medical examination including body composition analysis. HDL3-C levels were measured using the HDL3-EX SEIKEN kit (Randox Ltd., Crumlin, UK) and non-HDL3-C levels were calculated by subtracting HDL3-C levels from total HDL-C levels.
RESULTS
RESULTS
HDL3-C levels and HDL3-C proportion had a weak positive correlation with low-density lipoprotein cholesterol (LDL-C) and triglycerides (r=0.21, r=0.25; r=0.26, r=0.34, respectively, all
CONCLUSIONS
CONCLUSIONS
In populations with high HDL-C levels, HDL-C subclass may provide a greater amount of information on cardiovascular risk and MetS than HDL-C levels alone.
Identifiants
pubmed: 32067428
pii: 40.297
doi: 10.3343/alm.2020.40.4.297
pmc: PMC7054694
doi:
Substances chimiques
Cholesterol, HDL
0
Cholesterol, LDL
0
Reagent Kits, Diagnostic
0
Triglycerides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
297-305Subventions
Organisme : Konkuk University Medical Center
Pays : Korea
Informations de copyright
© The Korean Society for Laboratory Medicine.
Déclaration de conflit d'intérêts
No potential conflicts of interest relevant to this article were reported.
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