Ceftaroline versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) in an experimental MRSA meningitis model.

Animals Cephalosporins Meningitis Methicillin-Resistant Staphylococcus aureus Rabbits Staphylococcal Infections / drug therapy Vancomycin / pharmacology Ceftaroline
Animal model Central nervous system infection Glycopeptides Methicillin-resistant staphylococci Nosocomial meningitis Pharmacokinetics

Journal

Journal of global antimicrobial resistance
ISSN: 2213-7173
Titre abrégé: J Glob Antimicrob Resist
Pays: Netherlands
ID NLM: 101622459

Informations de publication

Date de publication:
09 2020
Historique:
received: 28 07 2019
revised: 02 01 2020
accepted: 02 02 2020
pubmed: 19 2 2020
medline: 24 6 2021
entrez: 19 2 2020
Statut: ppublish

Résumé

The aim of this study was to compare the antibacterial activity of ceftaroline versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) meningitis in an experimental rabbit meningitis model. The antibacterial activity of ceftaroline was compared with vancomycin in the treatment of meningitis induced by MRSA strain ATCC 43300 in an experimental rabbit meningitis model. Quantitative cerebrospinal fluid (CSF) cultures were performed at the beginning of antibiotic treatment and 24h and 73h after the first antibiotic dose. Furthermore, in vitro time-kill data were investigated at 0, 2, 4, 6, 8, 12 and 24h in sterile human serum. The difference between the control group versus both treatment groups was significant when comparing the decrease in colony counts in CSF both at 24h and 73h after the first antibiotic dose (P<0.05). At the end of the experiment, there was a significant difference in survival between both the ceftaroline-treated group and the vancomycin-treated group versus the control group, but not between the two treatment groups. These results suggest that the antibacterial activity of both ceftaroline and vancomycin are similar in the treatment of MRSA meningitis in an experimental rabbit meningitis model.

Identifiants

DOI: 10.1016/j.jgar.2020.02.001 PMID: 32068093
pubmed: 32068093
pii: S2213-7165(20)30027-8
doi: 10.1016/j.jgar.2020.02.001
pii:
doi:

Substances chimiques

Cephalosporins 0
Vancomycin 6Q205EH1VU

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

147-151

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

Auteurs

Sinan Mermer (S)

Cine State Hospital, Aydin, Turkey; Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Ege University, Bornova, Izmir, Turkey.

Tuncer Turhan (T)

Department of Neurosurgery, Faculty of Medicine, Ege University, Izmir, Turkey.

Elif Bolat (E)

Department of Neurosurgery, Faculty of Medicine, Ege University, Izmir, Turkey.

Sohret Aydemir (S)

Department of Medical Microbiology, Faculty of Medicine, Ege University, Izmir, Turkey.

Tansu Yamazhan (T)

Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Ege University, Bornova, Izmir, Turkey.

Husnu Pullukcu (H)

Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Ege University, Bornova, Izmir, Turkey.

Bilgin Arda (B)

Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Ege University, Bornova, Izmir, Turkey.

Hilal Sipahi (H)

Bornova Health Directorate, Izmir, Turkey.

Sercan Ulusoy (S)

Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Ege University, Bornova, Izmir, Turkey.

Oguz Resat Sipahi (OR)

Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Ege University, Bornova, Izmir, Turkey. Electronic address: oguz.resat.sipahi@ege.edu.tr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Ceftaroline versus vancomycin in the treatment...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Céphalosporines › Ceftaroline versus vancomycin in the treatment...
questionsmedicales.fr › Maladies du système nerveux › Méningite › Ceftaroline versus vancomycin in the treatment...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus résistant à la méticilline › Ceftaroline versus vancomycin in the treatment...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Lagomorpha › Lapins › Ceftaroline versus vancomycin in the treatment...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à staphylocoques › Ceftaroline versus vancomycin in the treatment...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Glycopeptides › Vancomycine › Ceftaroline versus vancomycin in the treatment...