A low glycemic diet protects disease-prone Nrf2-deficient mice against age-related macular degeneration.
Advanced glycation end-product
Antioxidant
Geographic atrophy
Glycemic index
Retinal pigmented epithelium
Journal
Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
17
10
2019
revised:
30
01
2020
accepted:
12
02
2020
pubmed:
19
2
2020
medline:
22
6
2021
entrez:
19
2
2020
Statut:
ppublish
Résumé
Age-related macular degeneration (AMD) is a major blinding disease, affecting over 14% of the elderly. Risk for AMD is related to age, diet, environment, and genetics. Dietary modulation of AMD risk is a promising treatment modality, but requires appropriate animal models to demonstrate advantages of diet. Mice lacking the antioxidant transcription factor Nrf2 (Nfe2l2) develop age-related retinopathy relevant to human AMD. Here we evaluated the effect of consuming high glycemic (HG) or low glycemic (LG) diets until 18-months of age on development of features relevant to AMD in Nrf2-null mice. Nrf2-null mice that consumed HG diets developed atrophic AMD, characterized by photoreceptor degeneration, retinal pigment epithelium (RPE) atrophy and pigmentary abnormalities, basal laminar deposits, and loss of the choriocapillaris. In contrast, Nrf2-null-mice that consumed LG diets did not develop retinal disease phenotypes. Consumption of HG diets was associated with accumulation of advanced glycation end-products in the RPE and systemically, whereas consumption of the LG diet was associated with increased levels of anti-glycative and anti-oxidative detoxification machinery. Together our data indicate that the Nrf2-null HG mouse is a good model for atrophic AMD studies and that the LG diet can activate protective pathways to prevent AMD, even in a genetically predisposed animal.
Identifiants
pubmed: 32068111
pii: S0891-5849(19)32165-3
doi: 10.1016/j.freeradbiomed.2020.02.010
pmc: PMC7747150
mid: NIHMS1643961
pii:
doi:
Substances chimiques
Glycation End Products, Advanced
0
NF-E2-Related Factor 2
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
75-86Subventions
Organisme : NEI NIH HHS
ID : R01 EY021212
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY026979
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY028559
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK124170
Pays : United States
Informations de copyright
Copyright © 2020. Published by Elsevier Inc.
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