Expression of NFIA and NFIB within the murine spinal cord.
NFIA
NFIB
Neurotrauma
Nuclear factor I
Spinal cord injury
Journal
Gene expression patterns : GEP
ISSN: 1872-7298
Titre abrégé: Gene Expr Patterns
Pays: Netherlands
ID NLM: 101167473
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
10
12
2019
revised:
06
02
2020
accepted:
11
02
2020
pubmed:
19
2
2020
medline:
5
1
2021
entrez:
19
2
2020
Statut:
ppublish
Résumé
The Nuclear factor I proteins comprise a family of transcription factors that are expressed in many developing and mature cell populations, including within the central nervous system. Within the embryonic mouse spinal cord, NFIA and NFIB are expressed by neural progenitor cells lining the central canal, where they act to promote astrocytic and oligodendrocytic lineage specification. Cells lining the mature spinal cord central canal retain characteristics of neural progenitor cells, but the expression of NFIA and NFIB within the mature spinal cord at a cell-type-specific level remains undefined. Here, we investigated where these two transcription factors are expressed within the adult mouse spinal cord. We reveal that both factors are expressed in similar cohorts of mature cells, including ependymal cells, interneurons and motor neurons. We also show robust and widespread expression of NFIA and NFIB within nestin-expressing cells following injury to the spinal cord. Collectively, these data provide a basis to further define what functional role(s) NFIA and NFIB play within the adult spinal cord.
Identifiants
pubmed: 32068188
pii: S1567-133X(19)30197-8
doi: 10.1016/j.gep.2020.119098
pii:
doi:
Substances chimiques
NFI Transcription Factors
0
Nfia protein, mouse
0
Nfib protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
119098Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest None.