Successful Stem Cell Apheresis Using Spectra Optia in a 6 kg Child With Atypical Teratoid/Rhabdoid Tumor.
Antineoplastic Combined Chemotherapy Protocols
/ therapeutic use
Combined Modality Therapy
Hematopoietic Stem Cell Transplantation
/ methods
Humans
Infant
Leukapheresis
/ instrumentation
Male
Peripheral Blood Stem Cells
/ cytology
Prognosis
Rhabdoid Tumor
/ pathology
Teratoma
/ pathology
Transplantation, Autologous
Journal
Journal of pediatric hematology/oncology
ISSN: 1536-3678
Titre abrégé: J Pediatr Hematol Oncol
Pays: United States
ID NLM: 9505928
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
pubmed:
19
2
2020
medline:
1
1
2021
entrez:
19
2
2020
Statut:
ppublish
Résumé
Peripheral blood stem cell apheresis has become a routine procedure for the collection of peripheral blood stem cells to enable high-dose chemotherapy followed by autologous stem cell transplantation in high-risk pediatric malignancies. However, the procedure remains challenging in very low-weight infants due to high extracorporeal blood volume and citrate toxicity. Our case report demonstrates in detail a successful and complication-free large-volume leukapheresis in a very small infant weighing 6 kg using a Spectra Optia apheresis system after placing a femoral double-lumen Shaldon catheter. Anticoagulation was achieved by citrate dextrose solution without the use of heparin. The total amount of blood being processed during the procedure equaled almost 4 times the total blood volume of the patient. The final apheresis product contained 14.0×10 CD34 cells/kg body weight. The infant was diagnosed with an atypical teratoid/rhabdoid tumor of the thalamus and third ventricle at the age of 3 months and had a history of epileptic seizures.
Identifiants
pubmed: 32068650
doi: 10.1097/MPH.0000000000001745
pii: 00043426-202010000-00045
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e692-e695Références
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