Platelet-derived transforming growth factor-β1 promotes keratinocyte proliferation in cutaneous wound healing.
blood platelets
epidermis
keratinocytes
platelet-rich plasma
skin
transforming growth factor beta
transgenic mouse
wound healing
Journal
Journal of tissue engineering and regenerative medicine
ISSN: 1932-7005
Titre abrégé: J Tissue Eng Regen Med
Pays: England
ID NLM: 101308490
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
15
04
2019
revised:
25
11
2019
accepted:
27
01
2020
pubmed:
19
2
2020
medline:
9
7
2021
entrez:
19
2
2020
Statut:
ppublish
Résumé
Platelets are a recognised potent source of transforming growth factor-β1 (TGFβ1), a cytokine known to promote wound healing and regeneration by stimulating dermal fibroblast proliferation and extracellular matrix deposition. Platelet lysate has been advocated as a novel personalised therapeutic to treat persistent wounds, although the precise platelet-derived growth factors responsible for these beneficial effects have not been fully elucidated. The aim of this study was to investigate the specific role of platelet-derived TGFβ1 in cutaneous wound healing. Using a transgenic mouse with a targeted deletion of TGFβ1 in megakaryocytes and platelets (TGFβ1
Identifiants
pubmed: 32068954
doi: 10.1002/term.3022
pmc: PMC7216944
doi:
Substances chimiques
Tgfb1 protein, mouse
0
Transforming Growth Factor beta1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
645-649Subventions
Organisme : Medical Research Council
ID : G0800340
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K004158/1
Pays : United Kingdom
Informations de copyright
© 2020 The Authors. Journal of Tissue Engineering and Regenerative Medicine published by John Wiley & Sons Ltd.
Références
Wound Repair Regen. 2002 May-Jun;10(3):177-87
pubmed: 12100379
Mil Med. 2014 Jul;179(7):799-805
pubmed: 25003868
Wound Repair Regen. 1995 Jan-Mar;3(1):25-36
pubmed: 17168860
J Cell Physiol. 1993 Apr;155(1):149-56
pubmed: 8468360
Platelets. 2015;26(2):101-13
pubmed: 24512369
Int J Dermatol. 2017 Mar;56(3):247-251
pubmed: 28181224
J Clin Invest. 2015 Aug 3;125(8):3008-26
pubmed: 26121747
Wound Repair Regen. 2007 Sep-Oct;15(5):748-55
pubmed: 17971021
J Cell Mol Med. 2009 Aug;13(8B):2030-8
pubmed: 19267882
J Tissue Eng Regen Med. 2020 Apr;14(4):645-649
pubmed: 32068954
Cell Cycle. 2016 Aug 2;15(15):2077-86
pubmed: 27295308
Cancer Res. 1995 Sep 1;55(17):3928-32
pubmed: 7641212
Arch Facial Plast Surg. 2004 Jan-Feb;6(1):21-5
pubmed: 14732640
J Immunol. 2004 Feb 1;172(3):1848-55
pubmed: 14734769
PLoS One. 2013 Dec 27;8(12):e84753
pubmed: 24386412
Cancer Cell. 2011 Nov 15;20(5):576-90
pubmed: 22094253
J Invest Dermatol. 2001 Feb;116(2):266-74
pubmed: 11180003