Repurposing Drugs for Acute Myeloid Leukemia: A Worthy Cause or a Futile Pursuit?
Acute myeloid leukemia
drug development
drug repurposing
mechanism of action
targeted therapies
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
13 Feb 2020
13 Feb 2020
Historique:
received:
25
01
2020
revised:
05
02
2020
accepted:
10
02
2020
entrez:
20
2
2020
pubmed:
20
2
2020
medline:
20
2
2020
Statut:
epublish
Résumé
Acute myeloid leukemia (AML) is a clinically and genetically heterogenous malignancy of myeloid progenitor cells that affects patients of all ages. Despite decades of research and improvement in overall outcomes, standard therapy remains ineffective for certain subtypes of AML. Current treatment is intensive and leads to a number of secondary effects with varying results by patient population. Due to the high cost of discovery and an unmet need for new targeted therapies that are well tolerated, alternative drug development strategies have become increasingly attractive. Repurposing existing drugs is one approach to identify new therapies with fewer financial and regulatory hurdles. In this review, we provide an overview of previously U.S. Food and Drug Administration (FDA) approved non-chemotherapy drugs under investigation for the treatment of AML.
Identifiants
pubmed: 32069925
pii: cancers12020441
doi: 10.3390/cancers12020441
pmc: PMC7072462
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Leukemia and Lymphoma Society
ID : 6587-20
Organisme : CURE Childhood Cancer
ID : N/A
Organisme : Stanford SPARK
ID : N/A
Organisme : American Society of Hematology
ID : MMSAP
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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