New era of optogenetics: from the central to peripheral nervous system.
Optogenetics
central nervous system
nerve regeneration
opsin
peripheral nervous system
Journal
Critical reviews in biochemistry and molecular biology
ISSN: 1549-7798
Titre abrégé: Crit Rev Biochem Mol Biol
Pays: England
ID NLM: 8903774
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
pubmed:
20
2
2020
medline:
9
1
2021
entrez:
20
2
2020
Statut:
ppublish
Résumé
Optogenetics has recently gained recognition as a biological technique to control the activity of cells using light stimulation. Many studies have applied optogenetics to cell lines in the central nervous system because it has the potential to elucidate neural circuits, treat neurological diseases and promote nerve regeneration. There have been fewer studies on the application of optogenetics in the peripheral nervous system. This review introduces the basic principles and approaches of optogenetics and summarizes the physiology and mechanism of opsins and how the technology enables bidirectional control of unique cell lines with superior spatial and temporal accuracy. Further, this review explores and discusses the therapeutic potential for the development of optogenetics and its capacity to revolutionize treatment for refractory epilepsy, depression, pain, and other nervous system disorders, with a focus on neural regeneration, especially in the peripheral nervous system. Additionally, this review synthesizes the latest preclinical research on optogenetic stimulation, including studies on non-human primates, summarizes the challenges, and highlights future perspectives. The potential of optogenetic stimulation to optimize therapy for peripheral nerve injuries (PNIs) is also highlighted. Optogenetic technology has already generated exciting, preliminary evidence, supporting its role in applications to several neurological diseases, including PNIs.
Identifiants
pubmed: 32070147
doi: 10.1080/10409238.2020.1726279
pmc: PMC7252884
mid: NIHMS1578971
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Video-Audio Media
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-16Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL118084
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS110387
Pays : United States
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