Neuroimaging and neurophysiological evaluation of severity of Parkinson's disease.
Dopamine transporter
Micro-electrode recording
Parkinson’s disease
Journal
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
ISSN: 1532-2653
Titre abrégé: J Clin Neurosci
Pays: Scotland
ID NLM: 9433352
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
02
12
2019
accepted:
08
02
2020
pubmed:
20
2
2020
medline:
20
9
2020
entrez:
20
2
2020
Statut:
ppublish
Résumé
Parkinson's disease (PD) is a neurodegenerative disease presenting characteristic motor features. Severity is usually assessed by clinical symptoms; however, few objective indicators are available. In this study, we evaluated the utility of dopamine transporter (DAT) imaging and subthalamic nucleus (STN) activities as indicators of PD severity. Twelve hemispheres of ten patients with PD who underwent deep brain stimulation (DBS) were included in this study. Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part 3 scores were used to evaluate clinical severity. The relationship between specific binding ratio (SBR) of DAT imaging and the root mean square (RMS) of STN micro-electrode recording (MER) was evaluated. A negative correlation was detected between the MDS-UPDRS part 3 scores and SBR (N = 20, R DAT findings may be useful in evaluating PD severity, especially rigidity and bradykinesia.
Identifiants
pubmed: 32070672
pii: S0967-5868(19)32348-3
doi: 10.1016/j.jocn.2020.02.006
pii:
doi:
Substances chimiques
Dopamine Plasma Membrane Transport Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
135-140Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.