Immune-modulating and anti-inflammatory marine compounds against cancer.
Anticancer treatment
Chronic inflammation
Immune system
Immunotherapy of cancer
Marine compounds
Journal
Seminars in cancer biology
ISSN: 1096-3650
Titre abrégé: Semin Cancer Biol
Pays: England
ID NLM: 9010218
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
09
10
2019
revised:
10
02
2020
accepted:
10
02
2020
pubmed:
20
2
2020
medline:
30
4
2022
entrez:
20
2
2020
Statut:
ppublish
Résumé
The recent advances in cancer immunotherapy confirm the crucial role of the immune system in cancer progression and treatment. Chronic inflammation and reduced immune surveillance are both features of the tumor microenvironment. Strategies aimed at reverting pro-tumor inflammation and stimulating the antitumor immune components are being actively searched, and the anticancer effects of many candidate drugs have been linked to their ability to modulate the immune system. Marine organisms constitute a rich reservoir of new bioactive molecules; some of them have already been exploited for pharmaceutical use, whereas many others are undergoing clinical or preclinical investigations for the treatment of different diseases, including cancer. In this review, we will discuss the immune-modulatory properties of marine compounds for their potential use in cancer prevention and treatment and as possible tools in the context of cancer immunotherapy.
Identifiants
pubmed: 32070764
pii: S1044-579X(20)30041-9
doi: 10.1016/j.semcancer.2020.02.008
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
58-72Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.