Relationship between a uterine fibroid diagnosis and the risk of adverse obstetrical outcomes: a cohort study.
Abruptio Placentae
/ epidemiology
Adult
Cesarean Section
/ adverse effects
Cohort Studies
Female
Fetal Growth Retardation
/ epidemiology
Humans
Leiomyoma
/ diagnosis
Postpartum Hemorrhage
/ epidemiology
Pregnancy
Pregnancy Complications
/ epidemiology
Pregnancy Complications, Neoplastic
/ diagnosis
Pregnancy Outcome
/ epidemiology
Premature Birth
/ epidemiology
Risk Factors
Uterine Myomectomy
/ methods
Uterine Neoplasms
/ diagnosis
Uterine Rupture
/ epidemiology
obstetrical complications
preterm birth
uterine fibroids
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
17 02 2020
17 02 2020
Historique:
entrez:
20
2
2020
pubmed:
20
2
2020
medline:
16
2
2021
Statut:
epublish
Résumé
The aim was to investigate the association between clinically significant uterine fibroids and preterm birth, caesarean section (CS), postpartum haemorrhage (PPH), placental abruption, intrauterine growth restriction (IUGR) and uterine rupture. A historical cohort study based on data from the Danish National Birth Cohort, the Danish National Patient Registry and the Danish National Birth Registry (DNBR). The final study population consisted of 92 696 pregnancies and was divided into four groups for comparison. Group 1: pregnancies of women without a fibroid diagnosis code or fibroid operation code; group 2: pregnancies of women with a fibroid diagnosis code before pregnancy, during pregnancy or up to 1 year after delivery, and no fibroid operation code before pregnancy; group 3: pregnancies of women with a fibroid diagnosis code given more than 1 year after delivery; and group 4: pregnancies of women with a fibroid operation code given before pregnancy. A diagnosis of fibroids before pregnancy yielded an increased risk of preterm birth (gestational age (GA) ≤37 weeks) (OR 2.27 (1.30─3.96)) and extreme preterm birth (GA 22+0─27+6 weeks, OR 20.09 (8.04─50.22)). The risk of CS was increased (OR 1.83 (1.23─2.72)) for women with a fibroid diagnosis code given before pregnancy; significantly increased risk of elective CS (OR 1.92 (1.11─3.32)), but not acute CS (OR 1.54 (0.94─2.52)). The risks of PPH, placental abruption or IUGR were not increased in any of the groups. We found a strong association between clinically significant uterine fibroids and preterm birth, and an association between clinically significant uterine fibroids and CS. In contrast, no association between clinically significant uterine fibroids and PPH, placental abruption or IUGR was seen.
Identifiants
pubmed: 32071172
pii: bmjopen-2019-032104
doi: 10.1136/bmjopen-2019-032104
pmc: PMC7044982
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e032104Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Am J Obstet Gynecol. 1989 May;160(5 Pt 1):1212-6
pubmed: 2658611
Epidemiology. 2006 Jul;17(4):413-8
pubmed: 16755269
J Matern Fetal Neonatal Med. 2012 Jun;25(6):710-3
pubmed: 22409539
Obstet Gynecol Sci. 2013 Nov;56(6):375-81
pubmed: 24396816
J Minim Invasive Gynecol. 2012 Nov-Dec;19(6):762-7
pubmed: 23084683
J Obstet Gynaecol Res. 2017 Dec;43(12):1789-1804
pubmed: 28892210
Obstet Gynecol Clin North Am. 2006 Mar;33(1):153-69
pubmed: 16504813
Eur J Epidemiol. 2010 May;25(5):349-55
pubmed: 20349116
Scand J Public Health. 2001 Dec;29(4):300-7
pubmed: 11775787
Best Pract Res Clin Obstet Gynaecol. 2016 Jul;34:74-84
pubmed: 26723475
Am J Obstet Gynecol. 2003 Jan;188(1):100-7
pubmed: 12548202
Ugeskr Laeger. 2009 Feb 2;171(6):412-5
pubmed: 19208329
Fertil Steril. 2009 Apr;91(4):1215-23
pubmed: 18339376
Acta Obstet Gynecol Scand. 2018 Apr;97(4):417-423
pubmed: 29453880
J Perinat Med. 1978;6(3):165-8
pubmed: 702266
J Matern Fetal Neonatal Med. 2015 Mar;28(4):484-8
pubmed: 24803127
Obstet Gynecol. 2009 Mar;113(3):630-5
pubmed: 19300327
Obstet Gynecol. 1988 Dec;72(6):853-7
pubmed: 3186092
Epidemiology. 2011 Sep;22(5):745
pubmed: 21811114
Am J Perinatol. 2016 Oct;33(12):1218-22
pubmed: 27631601
BMC Pregnancy Childbirth. 2017 Jan 10;17(1):17
pubmed: 28068990
Semin Reprod Med. 2010 May;28(3):218-27
pubmed: 20414844
Clin Exp Obstet Gynecol. 2016;43(6):844-848
pubmed: 29944235
Minerva Ginecol. 2010 Jun;62(3):225-36
pubmed: 20595947
Biomed Res Int. 2018 Mar 26;2018:8367068
pubmed: 30151390
Am J Obstet Gynecol. 2014 Oct;211(4):395.e1-5
pubmed: 24705132
Fertil Steril. 2012 Jan;97(1):107-10
pubmed: 22100166
Am J Clin Nutr. 1996 Oct;64(4):650-8
pubmed: 8839517
Clin Obstet Gynecol. 2016 Mar;59(1):119-27
pubmed: 26670833
Obstet Gynecol. 2000 May;95(5):764-9
pubmed: 10775744
J Matern Fetal Neonatal Med. 2016 Nov;29(21):3454-60
pubmed: 26653679
Am J Obstet Gynecol. 2008 Apr;198(4):357-66
pubmed: 18395031