Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke.
RIPK1
RIPK3
apoptosis
necroptosis
stroke
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
03 03 2020
03 03 2020
Historique:
pubmed:
20
2
2020
medline:
1
7
2020
entrez:
20
2
2020
Statut:
ppublish
Résumé
Apoptosis and necroptosis are two regulated cell death mechanisms; however, the interaction between these cell death pathways in vivo is unclear. Here we used cerebral ischemia/reperfusion as a model to investigate the interaction between apoptosis and necroptosis. We show that the activation of RIPK1 sequentially promotes necroptosis followed by apoptosis in a temporally specific manner. Cerebral ischemia/reperfusion insult rapidly activates necroptosis to promote cerebral hemorrhage and neuroinflammation.
Identifiants
pubmed: 32071228
pii: 1916427117
doi: 10.1073/pnas.1916427117
pmc: PMC7060720
doi:
Substances chimiques
Receptor-Interacting Protein Serine-Threonine Kinases
EC 2.7.11.1
Ripk1 protein, mouse
EC 2.7.11.1
Ripk3 protein, mouse
EC 2.7.11.1
MAP Kinase Kinase Kinases
EC 2.7.11.25
MAP kinase kinase kinase 7
EC 2.7.11.25
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4959-4970Subventions
Organisme : NIAID NIH HHS
ID : R01 AI075118
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA096899
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG055521
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG059073
Pays : United States
Déclaration de conflit d'intérêts
Competing interest statement: J.Y. is a consultant of Denali Therapeutics Inc., which has licensed the necrostatin technology. M.P. received consulting and speaker fees from Genentech, GlaxoSmithKline, Boehringer Ingelheim, and Sanofi. All other authors declare no competing interests.
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