Phasic signaling in the bed nucleus of the stria terminalis during fear learning predicts within- and across-session cued fear expression.
Journal
Learning & memory (Cold Spring Harbor, N.Y.)
ISSN: 1549-5485
Titre abrégé: Learn Mem
Pays: United States
ID NLM: 9435678
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
08
09
2019
accepted:
22
11
2019
entrez:
20
2
2020
pubmed:
20
2
2020
medline:
11
8
2021
Statut:
epublish
Résumé
While results from many past studies have implicated the bed nucleus of the stria terminalis (BNST) in mediating the expression of sustained negative affect, recent studies have highlighted a more complex role for BNST that includes aspects of fear learning in addition to defensive responding. As BNST is thought to encode ambiguous or unpredictable threat, it seems plausible that it may be involved in encoding early cued fear learning, especially immediately following a first tone-shock pairing when the conditioned stimulus-unconditioned stimulus (CS-US) contingency is not fully apparent. To investigate this, we conducted in vivo electrophysiological recording studies to examine neural dynamics of BNST units during cued fear acquisition and recall. We identified two functionally distinct subpopulations of BNST neurons that encode the intertrial interval (ITI) and may contribute to within- and across-session fear learning. "Ramping" cell activity during cued fear acquisition parallels the increase in freezing expression as mice learn the CS-US contingency, while "Phasic" cells encode postshock (US
Identifiants
pubmed: 32071254
pii: 27/3/83
doi: 10.1101/lm.050807.119
pmc: PMC7029722
doi:
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
83-90Informations de copyright
© 2020 Bjorni et al.; Published by Cold Spring Harbor Laboratory Press.
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