One year structural and functional glaucoma progression after trabeculectomy.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
18 02 2020
18 02 2020
Historique:
received:
04
09
2019
accepted:
04
02
2020
entrez:
20
2
2020
pubmed:
20
2
2020
medline:
20
11
2020
Statut:
epublish
Résumé
We evaluated the changes in visual field mean deviation (VF MD) and retinal nerve fibre layer (RNFL) thickness in glaucoma patients undergoing trabeculectomy. One hundred patients were examined with VF and spectral-domain optical coherence tomography (OCT) before trabeculectomy and 4 follow-up visits over one year. Linear mixed models were used to investigate factors associated with VF and RNFL. VF improved during the first 3 months of follow-up (2.55 ± 1.06 dB/year) and worsened at later visits (-1.14 ± 0.29 dB/year). RNFL thickness reduced by -4.21 ± 0.25 µm/year from 1st month of follow-up. Eyes with an absence of initial VF improvement (β = 0.64; 0.30-0.98), RNFL thinning (β = 0.15; 0.08-0.23), increasing intraocular pressure (IOP; β = -0.11; -0.18 to -0.03) and severe glaucoma (β = -10.82; -13.61 to -8.02) were associated with VF deterioration. Eyes with VF deterioration (β = 0.19; 0.08-0.29), increasing IOP (β = -0.09; -0.17 to -0.01), and moderate (β = -6.33; -12.17 to -0.49) or severe glaucoma (β = -19.58; -24.63 to -14.52) were associated with RNFL thinning. Changes in RNFL structure and function occur over a 1-year follow-up period after trabeculectomy. Early VF improvement is more likely to occur in patients with mild/moderate glaucoma, whereas those with severe glaucoma show greater decline over one year. Our findings indicate that progression is observable using OCT, even in late-stage glaucoma.
Identifiants
pubmed: 32071369
doi: 10.1038/s41598-020-59792-9
pii: 10.1038/s41598-020-59792-9
pmc: PMC7029027
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2808Références
The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration.The AGIS Investigators. American journal of ophthalmology 130, 429–440 (2000).
doi: 10.1016/S0002-9394(00)00538-9
Lichter, P. R. et al. Interim clinical outcomes in the Collaborative Initial Glaucoma Treatment Study comparing initial treatment randomized to medications or surgery. Ophthalmology 108, 1943–1953 (2001).
doi: 10.1016/S0161-6420(01)00873-9
The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma. Collaborative Normal-Tension Glaucoma Study Group. American journal of ophthalmology 126, 498–505 (1998).
doi: 10.1016/S0002-9394(98)00272-4
Heijl, A. et al. Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial. Archives of ophthalmology 120, 1268–1279 (2002).
doi: 10.1001/archopht.120.10.1268
Garway-Heath, D. F. et al. Latanoprost for open-angle glaucoma (UKGTS): a randomised, multicentre, placebo-controlled trial. Lancet 385, 1295–1304, https://doi.org/10.1016/S0140-6736(14)62111-5 (2015).
doi: 10.1016/S0140-6736(14)62111-5
pubmed: 25533656
Wright, T. M., Goharian, I., Gardiner, S. K., Sehi, M. & Greenfield, D. S. Short-term enhancement of visual field sensitivity in glaucomatous eyes following surgical intraocular pressure reduction. American journal of ophthalmology 159, 378–385 e371, https://doi.org/10.1016/j.ajo.2014.11.012 (2015).
doi: 10.1016/j.ajo.2014.11.012
pubmed: 25447113
Caprioli, J. et al. Trabeculectomy Can Improve Long-Term Visual Function in Glaucoma. Ophthalmology 123, 117–128, https://doi.org/10.1016/j.ophtha.2015.09.027 (2016).
doi: 10.1016/j.ophtha.2015.09.027
pubmed: 26602970
Musch, D. C. et al. Visual field improvement in the collaborative initial glaucoma treatment study. American journal of ophthalmology 158, 96–104 e102, https://doi.org/10.1016/j.ajo.2014.04.003 (2014).
doi: 10.1016/j.ajo.2014.04.003
pubmed: 24727262
pmcid: 4190842
Spaeth, G. L. The effect of change in intraocular pressure on the natural history of glaucoma: lowering intraocular pressure in glaucoma can result in improvement of visual fields. Transactions of the ophthalmological societies of the United Kingdom 104(Pt 3), 256–264 (1985).
pubmed: 3861005
Katz, L. J., Spaeth, G. L., Cantor, L. B., Poryzees, E. M. & Steinmann, W. C. Reversible optic disk cupping and visual field improvement in adults with glaucoma. American journal of ophthalmology 107, 485–492 (1989).
doi: 10.1016/0002-9394(89)90492-3
Kotecha, A. et al. Optic disc and visual field changes after trabeculectomy. Investigative ophthalmology & visual science 50, 4693–4699, https://doi.org/10.1167/iovs.08-3115 (2009).
doi: 10.1167/iovs.08-3115
Parrish, R. K. 2nd et al. Five-year follow-up optic disc findings of the Collaborative Initial Glaucoma Treatment Study. American journal of ophthalmology 147, 717–724 e711, https://doi.org/10.1016/j.ajo.2008.10.007 (2009).
doi: 10.1016/j.ajo.2008.10.007
pubmed: 19152871
pmcid: 2714658
Figus, M. et al. Short-term changes in the optic nerve head and visual field after trabeculectomy. Eye 25, 1057–1063, https://doi.org/10.1038/eye.2011.119 (2011).
doi: 10.1038/eye.2011.119
pubmed: 21617695
pmcid: 3178201
Aydin, A., Wollstein, G., Price, L. L., Fujimoto, J. G. & Schuman, J. S. Optical coherence tomography assessment of retinal nerve fiber layer thickness changes after glaucoma surgery. Ophthalmology 110, 1506–1511, https://doi.org/10.1016/S0161-6420(03)00493-7 (2003).
doi: 10.1016/S0161-6420(03)00493-7
pubmed: 12917164
pmcid: 1939722
Sogano, S., Tomita, G. & Kitazawa, Y. Changes in retinal nerve fiber layer thickness after reduction of intraocular pressure in chronic open-angle glaucoma. Ophthalmology 100, 1253–1258 (1993).
doi: 10.1016/S0161-6420(93)31497-1
Raghu, N., Pandav, S. S., Kaushik, S., Ichhpujani, P. & Gupta, A. Effect of trabeculectomy on RNFL thickness and optic disc parameters using optical coherence tomography. Eye (Lond) 26, 1131–1137, https://doi.org/10.1038/eye.2012.115 (2012).
doi: 10.1038/eye.2012.115
Yamada, N., Tomita, G., Yamamoto, T. & Kitazawa, Y. Changes in the nerve fiber layer thickness following a reduction of intraocular pressure after trabeculectomy. J Glaucoma 9, 371–375 (2000).
doi: 10.1097/00061198-200010000-00005
Membrey, W. L., Bunce, C., Poinoosawmy, D. P., Fitzke, F. W. & Hitchings, R. A. Glaucoma surgery with or without adjunctive antiproliferatives in normal tension glaucoma: 2 Visual field progression. The British journal of ophthalmology 85, 696–701 (2001).
doi: 10.1136/bjo.85.6.696
Musch, D. C. et al. Intraocular pressure control and long-term visual field loss in the Collaborative Initial Glaucoma Treatment Study. Ophthalmology 118, 1766–1773, https://doi.org/10.1016/j.ophtha.2011.01.047 (2011).
doi: 10.1016/j.ophtha.2011.01.047
pubmed: 21600658
pmcid: 3161134
Folgar, F. A. et al. Effect of successful and partly successful filtering surgery on the velocity of glaucomatous visual field progression. Journal of glaucoma 21, 615–618, https://doi.org/10.1097/IJG.0b013e31821db409 (2012).
doi: 10.1097/IJG.0b013e31821db409
pubmed: 21623221
Baril, C. et al. Rates of glaucomatous visual field change after trabeculectomy. The British journal of ophthalmology 101, 874–878, https://doi.org/10.1136/bjophthalmol-2016-308948 (2017).
doi: 10.1136/bjophthalmol-2016-308948
pubmed: 27811280
Naito, T. et al. Effect of trabeculectomy on visual field progression in Japanese progressive normal-tension glaucoma with intraocular pressure <15 mmHg. PloS one 12, e0184096, https://doi.org/10.1371/journal.pone.0184096 (2017).
doi: 10.1371/journal.pone.0184096
pubmed: 28850613
pmcid: 5574552
Mwanza, J. C. et al. Retinal nerve fibre layer thickness floor and corresponding functional loss in glaucoma. The British journal of ophthalmology 99, 732–737, https://doi.org/10.1136/bjophthalmol-2014-305745 (2015).
doi: 10.1136/bjophthalmol-2014-305745
pubmed: 25492547
Mwanza, J. C. et al. Residual and Dynamic Range of Retinal Nerve Fiber Layer Thickness in Glaucoma: Comparison of Three OCT Platforms. Investigative ophthalmology & visual science 56, 6344–6351, https://doi.org/10.1167/iovs.15-17248 (2015).
doi: 10.1167/iovs.15-17248
Miraftabi, A. et al. Macular SD-OCT Outcome Measures: Comparison of Local Structure-Function Relationships and Dynamic Range. Investigative ophthalmology & visual science 57, 4815–4823, https://doi.org/10.1167/iovs.16-19648 (2016).
doi: 10.1167/iovs.16-19648
Bowd, C., Zangwill, L. M., Weinreb, R. N., Medeiros, F. A. & Belghith, A. Estimating Optical Coherence Tomography Structural Measurement Floors to Improve Detection of Progression in Advanced Glaucoma. American journal of ophthalmology 175, 37–44, https://doi.org/10.1016/j.ajo.2016.11.010 (2017).
doi: 10.1016/j.ajo.2016.11.010
pubmed: 27914978
Lavinsky, F. et al. Can Macula and Optic Nerve Head Parameters Detect Glaucoma Progression in Eyes with Advanced Circumpapillary Retinal Nerve Fiber Layer Damage? Ophthalmology 125, 1907–1912, https://doi.org/10.1016/j.ophtha.2018.05.020 (2018).
doi: 10.1016/j.ophtha.2018.05.020
pubmed: 29934267
pmcid: 6246816
Pavlidis, M., Stupp, T., Naskar, R., Cengiz, C. & Thanos, S. Retinal ganglion cells resistant to advanced glaucoma: a postmortem study of human retinas with the carbocyanine dye DiI. Investigative ophthalmology & visual science 44, 5196–5205 (2003).
doi: 10.1167/iovs.03-0614
Kadziauskiene, A. et al. Long-Term Shape, Curvature, and Depth Changes of the Lamina Cribrosa after Trabeculectomy. Ophthalmology 125, 1729–1740, https://doi.org/10.1016/j.ophtha.2018.05.011 (2018).
doi: 10.1016/j.ophtha.2018.05.011
pubmed: 29961552
Krzyzanowska-Berkowska, P., Melinska, A., Helemejko, I. & Robert Iskander, D. Evaluating displacement of lamina cribrosa following glaucoma surgery. Graefes Arch Clin Exp Ophthalmol 256, 791–800, https://doi.org/10.1007/s00417-018-3920-1 (2018).
doi: 10.1007/s00417-018-3920-1
pubmed: 29423838
pmcid: 5856897
Krzyzanowska-Berkowska, P., Czajor, K., Helemejko, I. & Iskander, D. R. Relationship between the rate of change in lamina cribrosa depth and the rate of retinal nerve fiber layer thinning following glaucoma surgery. PLoS One 13, e0206040, https://doi.org/10.1371/journal.pone.0206040 (2018).
doi: 10.1371/journal.pone.0206040
pubmed: 30399148
pmcid: 6219770
Ha, A. et al. Baseline Lamina Cribrosa Curvature and Subsequent Visual Field Progression Rate in Primary Open-Angle Glaucoma. Ophthalmology 125, 1898–1906, https://doi.org/10.1016/j.ophtha.2018.05.017 (2018).
doi: 10.1016/j.ophtha.2018.05.017
pubmed: 29945800
Leung, C. K. Optical Coherence Tomography Imaging for Glaucoma - Today and Tomorrow. Asia Pac. J Ophthalmol (Phila) 5, 11–16, https://doi.org/10.1097/APO.0000000000000179 (2016).
doi: 10.1097/APO.0000000000000179
Mwanza, J. C., Warren, J. L. & Budenz, D. L. Utility of combining spectral domain optical coherence tomography structural parameters for the diagnosis of early Glaucoma: a mini-review. Eye and vision 5, 9, https://doi.org/10.1186/s40662-018-0101-6 (2018).
doi: 10.1186/s40662-018-0101-6
pubmed: 29725607
pmcid: 5921308
Susanna, R. Jr. & Vessani, R. M. Staging glaucoma patient: why and how? Open Ophthalmol J 3, 59–64, https://doi.org/10.2174/1874364100903020059 (2009).
doi: 10.2174/1874364100903020059
pubmed: 19834563
Girard, M. J., Strouthidis, N. G., Ethier, C. R. & Mari, J. M. Shadow removal and contrast enhancement in optical coherence tomography images of the human optic nerve head. Investigative ophthalmology & visual science 52, 7738–7748, https://doi.org/10.1167/iovs.10-6925 (2011).
doi: 10.1167/iovs.10-6925
Girard, M. J. et al. Lamina cribrosa visibility using optical coherence tomography: comparison of devices and effects of image enhancement techniques. Investigative ophthalmology & visual science 56, 865–874, https://doi.org/10.1167/iovs.14-14903 (2015).
doi: 10.1167/iovs.14-14903
Mari, J. M., Strouthidis, N. G., Park, S. C. & Girard, M. J. Enhancement of lamina cribrosa visibility in optical coherence tomography images using adaptive compensation. Investigative ophthalmology & visual science 54, 2238–2247, https://doi.org/10.1167/iovs.12-11327 (2013).
doi: 10.1167/iovs.12-11327
Thakku, S. G. et al. A Global Shape Index to Characterize Anterior Lamina Cribrosa Morphology and Its Determinants in Healthy Indian Eyes. Investigative ophthalmology & visual science 56, 3604–3614, https://doi.org/10.1167/iovs.15-16707 (2015).
doi: 10.1167/iovs.15-16707