Click-tambjamines as efficient and tunable bioactive anion transporters.
A549 Cells
Anions
/ chemical synthesis
Antineoplastic Agents
/ chemical synthesis
Cell Line
Cell Proliferation
/ drug effects
Crystallography, X-Ray
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Ion Transport
Liposomes
/ chemistry
MCF-7 Cells
Models, Molecular
Molecular Structure
Pyrroles
/ chemical synthesis
Structure-Activity Relationship
Journal
Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838
Informations de publication
Date de publication:
12 Mar 2020
12 Mar 2020
Historique:
pubmed:
20
2
2020
medline:
25
3
2020
entrez:
20
2
2020
Statut:
ppublish
Résumé
A novel class of transmembrane anion carriers, the click-tambjamines, display remarkable anionophoric activities in model liposomes and living cells. The versatility of this building block for the generation of molecular diversity offers promise to develop future drugs based on this design.
Substances chimiques
Anions
0
Antineoplastic Agents
0
Liposomes
0
Pyrroles
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM