Potent Inhibition of Thioredoxin Reductase by the Rh Derivatives of Anticancer M(arene/Cp*)(NHC)Cl
Antineoplastic Agents
/ chemical synthesis
Cell Line, Tumor
Cell Proliferation
/ drug effects
Coordination Complexes
/ chemical synthesis
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Enzyme Inhibitors
/ chemical synthesis
Heterocyclic Compounds
/ chemistry
Humans
Ligands
Metals, Heavy
/ chemistry
Methane
/ analogs & derivatives
Molecular Conformation
Structure-Activity Relationship
Thioredoxin-Disulfide Reductase
/ antagonists & inhibitors
Journal
Inorganic chemistry
ISSN: 1520-510X
Titre abrégé: Inorg Chem
Pays: United States
ID NLM: 0366543
Informations de publication
Date de publication:
02 Mar 2020
02 Mar 2020
Historique:
pubmed:
20
2
2020
medline:
30
9
2020
entrez:
20
2
2020
Statut:
ppublish
Résumé
Metal complexes provide a versatile platform to develop novel anticancer pharmacophores, and they form stable compounds with
Identifiants
pubmed: 32073260
doi: 10.1021/acs.inorgchem.9b03640
doi:
Substances chimiques
Antineoplastic Agents
0
Coordination Complexes
0
Enzyme Inhibitors
0
Heterocyclic Compounds
0
Ligands
0
Metals, Heavy
0
carbene
2465-56-7
Thioredoxin-Disulfide Reductase
EC 1.8.1.9
Methane
OP0UW79H66
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM