Delayed correlations improve the reconstruction of the brain connectome.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
05
09
2019
accepted:
13
01
2020
entrez:
20
2
2020
pubmed:
20
2
2020
medline:
25
4
2020
Statut:
epublish
Résumé
The brain works as a large-scale complex network, known as the connectome. The strength of the connections between two brain regions in the connectome is commonly estimated by calculating the correlations between their patterns of activation. This approach relies on the assumption that the activation of connected regions occurs together and at the same time. However, there are delays between the activation of connected regions due to excitatory and inhibitory connections. Here, we propose a method to harvest this additional information and reconstruct the structural brain connectome using delayed correlations. This delayed-correlation method correctly identifies 70% to 80% of connections of simulated brain networks, compared to only 5% to 25% of connections detected by the standard methods; this result is robust against changes in the network parameters (small-worldness, excitatory vs. inhibitory connection ratio, weight distribution) and network activation dynamics. The delayed-correlation method predicts more accurately both the global network properties (characteristic path length, global efficiency, clustering coefficient, transitivity) and the nodal network properties (nodal degree, nodal clustering, nodal global efficiency), particularly at lower network densities. We obtain similar results in networks derived from animal and human data. These results suggest that the use of delayed correlations improves the reconstruction of the structural brain connectome and open new possibilities for the analysis of the brain connectome, as well as for other types of networks.
Identifiants
pubmed: 32074115
doi: 10.1371/journal.pone.0228334
pii: PONE-D-19-25044
pmc: PMC7029855
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0228334Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Cogn Neurodyn. 2014 Feb;8(1):1-15
pubmed: 24465281
PLoS Comput Biol. 2008 Nov;4(11):e1000219
pubmed: 19008942
Nat Rev Neurosci. 2009 Mar;10(3):186-98
pubmed: 19190637
Neuroimage. 2012 Feb 1;59(3):2142-54
pubmed: 22019881
Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):2035-40
pubmed: 19188601
Proc Natl Acad Sci U S A. 2015 May 26;112(21):E2820-8
pubmed: 25964365
Hum Brain Mapp. 2009 Oct;30(10):3127-41
pubmed: 19235882
PLoS Comput Biol. 2008 Oct;4(10):e1000196
pubmed: 18846206
Nat Rev Neurosci. 2011 Jan;12(1):43-56
pubmed: 21170073
Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2825-30
pubmed: 22308319
Nature. 1998 Jun 4;393(6684):440-2
pubmed: 9623998
Neuroimage. 2008 Feb 15;39(4):1666-81
pubmed: 18082428
Eur Neuropsychopharmacol. 2010 Aug;20(8):519-34
pubmed: 20471808
Neuron. 2015 Aug 19;87(4):684-98
pubmed: 26291155
Proc Natl Acad Sci U S A. 2011 May 3;108(18):7641-6
pubmed: 21502525
Brain Struct Funct. 2009 Oct;213(6):525-33
pubmed: 19565262
Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):10032-7
pubmed: 26216962
Science. 2013 Nov 1;342(6158):1238411
pubmed: 24179229
Philos Trans R Soc Lond B Biol Sci. 2005 May 29;360(1457):969-81
pubmed: 16087441
Neuroimage. 2003 Aug;19(4):1477-91
pubmed: 12948704
PLoS One. 2012;7(3):e32766
pubmed: 22412922
Nature. 2003 Oct 30;425(6961):954-6
pubmed: 14586468
PLoS One. 2008 May 14;3(5):e2148
pubmed: 18478091
Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5187-92
pubmed: 23479610
Neuroscientist. 2006 Dec;12(6):512-23
pubmed: 17079517
Neuron. 2015 Oct 7;88(1):207-19
pubmed: 26447582
Philos Trans R Soc Lond B Biol Sci. 2005 May 29;360(1457):937-46
pubmed: 16087438
Cereb Cortex. 1999 Apr-May;9(3):277-99
pubmed: 10355908
Nat Rev Neurosci. 2002 Aug;3(8):606-16
pubmed: 12154362
Nat Commun. 2017 Nov 7;8(1):1349
pubmed: 29116093
Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16574-9
pubmed: 25368179
PLoS Biol. 2008 Jul 1;6(7):e159
pubmed: 18597554
Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Aug;80(2 Pt 2):026206
pubmed: 19792230
Cereb Cortex. 2013 Jan;23(1):127-38
pubmed: 22275481
PLoS Comput Biol. 2005 Sep;1(4):e42
pubmed: 16201007
Neuroimage. 2011 Jan 15;54(2):875-91
pubmed: 20817103
Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6169-74
pubmed: 23530246
Sci Rep. 2015 Jan 19;5:7870
pubmed: 25598302
PLoS One. 2016 Apr 11;11(4):e0153105
pubmed: 27064897
Biophys J. 1961 Jul;1(6):445-66
pubmed: 19431309
Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11747-52
pubmed: 19564605
Front Neurosci. 2017 Feb 17;11:75
pubmed: 28261052
Magn Reson Med. 1995 Oct;34(4):537-41
pubmed: 8524021
Brain Connect. 2013;3(6):547-62
pubmed: 24063289
Cereb Cortex. 2016 Aug;26(8):3476-3493
pubmed: 27178195
Neuroimage. 2013 Feb 1;66:311-7
pubmed: 23142654
Proc Natl Acad Sci U S A. 2018 May 22;115(21):E4880-E4889
pubmed: 29739890
Neuroimage. 2010 Sep;52(3):1059-69
pubmed: 19819337
Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10240-5
pubmed: 17548818
Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10302-7
pubmed: 19497858
PLoS One. 2019 Jul 26;14(7):e0220061
pubmed: 31348798
Neuron. 2011 Nov 17;72(4):665-78
pubmed: 22099467
Brain Connect. 2011;1(1):13-36
pubmed: 22432952
Nat Rev Neurosci. 2001 Apr;2(4):229-39
pubmed: 11283746
Neuroimage. 2014 Apr 15;90:335-47
pubmed: 24384152
Front Syst Neurosci. 2011 Nov 23;5:96
pubmed: 22131968
J Mol Neurosci. 2008;34(1):51-61
pubmed: 18157658
Int J Psychophysiol. 1996 Oct;23(3):145-53
pubmed: 8947780
Neuroimage. 2018 Sep;178:57-68
pubmed: 29758339
Cereb Cortex. 2012 Jul;22(7):1586-92
pubmed: 21893683
Neuroimage. 2012 Oct 1;62(4):2222-31
pubmed: 22366334
Neuroimage. 2011 Jan 15;54(2):807-23
pubmed: 20884354
Nature. 2014 Apr 10;508(7495):207-14
pubmed: 24695228
Neuroimage. 2012 Aug 15;62(2):1257-66
pubmed: 22248579
Nat Methods. 2013 Jun;10(6):491-3
pubmed: 23722207
Neuron. 2006 Sep 7;51(5):527-39
pubmed: 16950152
Cereb Cortex. 2014 Jan;24(1):17-36
pubmed: 23010748
Neuroimage. 2003 Oct;20(2):962-74
pubmed: 14568466
Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13982-7
pubmed: 23924609
Phys Rev Lett. 2004 Apr 9;92(14):144101
pubmed: 15089542
Neuroimage. 2005 Mar;25(1):230-42
pubmed: 15734358
Neuroimage. 2010 Sep;52(3):766-76
pubmed: 20116438
Phys Rev Lett. 2001 Nov 5;87(19):198701
pubmed: 11690461
Neuron. 2015 Jun 17;86(6):1518-29
pubmed: 26087168
Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):833-8
pubmed: 24379387
Genes Brain Behav. 2003 Oct;2(5):255-67
pubmed: 14606691