Bioactive Phenolic Compounds in the Modulation of Central and Peripheral Nervous System Cancers: Facts and Misdeeds.
bioavailability
brain cancer
gliomas
malignant tumors of the peripheral nerve sheath (MPNST)
nanoparticle-based delivery systems
neurofibromas
polyphenols
schwannomas
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
15 Feb 2020
15 Feb 2020
Historique:
received:
16
01
2020
revised:
11
02
2020
accepted:
12
02
2020
entrez:
21
2
2020
pubmed:
23
2
2020
medline:
23
2
2020
Statut:
epublish
Résumé
Efficacious therapies are not available for the cure of both gliomas and glioneuronal tumors, which represent the most numerous and heterogeneous primary cancers of the central nervous system (CNS), and for neoplasms of the peripheral nervous system (PNS), which can be divided into benign tumors, mainly represented by schwannomas and neurofibromas, and malignant tumors of the peripheral nerve sheath (MPNST). Increased cellular oxidative stress and other metabolic aspects have been reported as potential etiologies in the nervous system tumors. Thus polyphenols have been tested as effective natural compounds likely useful for the prevention and therapy of this group of neoplasms, because of their antioxidant and anti-inflammatory activity. However, polyphenols show poor intestinal absorption due to individual intestinal microbiota content, poor bioavailability, and difficulty in passing the blood-brain barrier (BBB). Recently, polymeric nanoparticle-based polyphenol delivery improved their gastrointestinal absorption, their bioavailability, and entry into defined target organs. Herein, we summarize recent findings about the primary polyphenols employed for nervous system tumor prevention and treatment. We describe the limitations of their application in clinical practice and the new strategies aimed at enhancing their bioavailability and targeted delivery.
Identifiants
pubmed: 32075265
pii: cancers12020454
doi: 10.3390/cancers12020454
pmc: PMC7072310
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Italian Ministry of Economic Development (MiSE) - Fund for Sustainable Development - Call "HORIZON2020" PON I&C 2014-2020
ID : F/050347/01_03/X32
Organisme : University of Campania Luigi Vanvitelli Program V:ALERE 2019
ID : Id343
Organisme : Regione Campania (RIS 3 - POR FESR 2007/2013 - Obiettivo 2.1)
ID : DIP. 54 - DG 91 n. 403, 15/10/2015
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