Genomic and Epidemiological Surveillance of Zika Virus in the Amazon Region.

Brazil / epidemiology Epidemiological Monitoring Female Genomics / methods Humans Male Zika Virus / genetics Zika Virus Infection / epidemiology

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
18 02 2020
Historique:
received: 03 06 2019
revised: 16 12 2019
accepted: 24 01 2020
pubmed: 23 2 2020
medline: 10 3 2021
entrez: 21 2 2020
Statut: ppublish

Résumé

Zika virus (ZIKV) has caused an explosive epidemic linked to severe clinical outcomes in the Americas. As of June 2018, 4,929 ZIKV suspected infections and 46 congenital syndrome cases had been reported in Manaus, Amazonas, Brazil. Although Manaus is a key demographic hub in the Amazon region, little is known about the ZIKV epidemic there, in terms of both transmission and viral genetic diversity. Using portable virus genome sequencing, we generated 59 ZIKV genomes in Manaus. Phylogenetic analyses indicated multiple introductions of ZIKV from northeastern Brazil to Manaus. Spatial genomic analysis of virus movement among six areas in Manaus suggested that populous northern neighborhoods acted as sources of virus transmission to other neighborhoods. Our study revealed how the ZIKV epidemic was ignited and maintained within the largest urban metropolis in the Amazon. These results might contribute to improving the public health response to outbreaks in Brazil.

Identifiants

DOI: 10.1016/j.celrep.2020.01.085 PMID: 32075736
pubmed: 32075736
pii: S2211-1247(20)30119-4
doi: 10.1016/j.celrep.2020.01.085
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2275-2283.e7

Subventions

Organisme : Medical Research Council
ID : MR/S035362/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M501621/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204311/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S019510/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_15100
Pays : United Kingdom
Organisme : NICHD NIH HHS
ID : T32 HD040128
Pays : United States

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

Auteurs

Marta Giovanetti (M)

Laboratório de Flavivírus, Instituto Oswaldo Cruz Fiocruz, Rio de Janeiro, Brazil; Laboratório de Genética Celular e Molecular, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Nuno Rodrigues Faria (NR)

Laboratório de Genética Celular e Molecular, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; Department of Zoology, University of Oxford, Oxford OX1 3PS, UK. Electronic address: nuno.faria@zoo.ox.ac.uk.

José Lourenço (J)

Department of Zoology, University of Oxford, Oxford OX1 3PS, UK.

Jaqueline Goes de Jesus (J)

Laboratório de Flavivírus, Instituto Oswaldo Cruz Fiocruz, Rio de Janeiro, Brazil.

Joilson Xavier (J)

Laboratório de Genética Celular e Molecular, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Ingra Morales Claro (IM)

Instituto de Medicina Tropical, Universidade de São Paulo, São Paulo, Brazil.

Moritz U G Kraemer (MUG)

Department of Zoology, University of Oxford, Oxford OX1 3PS, UK.

Vagner Fonseca (V)

Laboratório de Genética Celular e Molecular, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), College of Health Sciences, University of KwaZuluNatal, Durban 4001, South Africa.

Simon Dellicour (S)

Spatial Epidemiology Lab, Université Libre de Bruxelles, Bruxelles, Belgium; KU Leuven, Department of Microbiology and Immunology, Rega Institute, Laboratory for Clinical and Epidemiological Virology, Leuven, Belgium.

Julien Thézé (J)

Department of Zoology, University of Oxford, Oxford OX1 3PS, UK.

Flavia da Silva Salles (F)

Instituto de Medicina Tropical, Universidade de São Paulo, São Paulo, Brazil.

Tiago Gräf (T)

Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.

Paola Paz Silveira (PP)

Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.

Valdinete Alves do Nascimento (VA)

Laboratório de Ecologia de Doenças Transmissíveis na Amazônia, Instituto Leônidas e Maria Deane, Fiocruz, Manaus, Brazil.

Victor Costa de Souza (V)

Laboratório de Ecologia de Doenças Transmissíveis na Amazônia, Instituto Leônidas e Maria Deane, Fiocruz, Manaus, Brazil.

Felipe Campos de Melo Iani (FC)

Laboratório de Genética Celular e Molecular, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; Laboratório Central de Saúde Pública, Fundação Ezequiel Dias, Belo Horizonte, Brazil.

Emerson Augusto Castilho-Martins (EA)

Faculdade de Medicina, Universidade Federal do Amapá, Macapá, Brazil.

Laura Nogueira Cruz (LN)

Coordenação Geral dos Laboratórios de Saúde Pública/Secretaria de Vigilância em Saúde, Ministério da Saúde (CGLAB/SVS-MS), Brasília, Distrito Federal, Brazil.

Gabriel Wallau (G)

Fundação Oswaldo Cruz - Instituto Aggeu Magalhães, Recife, Pernambuco, Brazil.

Allison Fabri (A)

Laboratório de Flavivírus, Instituto Oswaldo Cruz Fiocruz, Rio de Janeiro, Brazil.

Flávia Levy (F)

Laboratório de Flavivírus, Instituto Oswaldo Cruz Fiocruz, Rio de Janeiro, Brazil.

Joshua Quick (J)

Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK.

Vasco de Azevedo (V)

Laboratório de Genética Celular e Molecular, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Renato Santana Aguiar (RS)

Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.

Tulio de Oliveira (T)

KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), College of Health Sciences, University of KwaZuluNatal, Durban 4001, South Africa.

Camila Bôtto de Menezes (C)

Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil.

Marcia da Costa Castilho (M)

Departamento de Virologia, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, Amazonas, Brazil.

Tirza Matos Terra (TM)

Laboratório Central de Saúde Pública do Amazonas, Manaus, Amazonas, Brazil.

Marineide Souza da Silva (M)

Laboratório Central de Saúde Pública do Amazonas, Manaus, Amazonas, Brazil.

Ana Maria Bispo de Filippis (AM)

Laboratório de Flavivírus, Instituto Oswaldo Cruz Fiocruz, Rio de Janeiro, Brazil.

André Luiz de Abreu (A)

Coordenação Geral dos Laboratórios de Saúde Pública/Secretaria de Vigilância em Saúde, Ministério da Saúde (CGLAB/SVS-MS), Brasília, Distrito Federal, Brazil.

Wanderson Kleber Oliveira (WK)

Secretaria de Vigilância em Saúde, Ministério da Saúde (SVS-MS), Brasília, Distrito Federal, Brazil.

Julio Croda (J)

Departamento de Vigilância de Doenças Transmissíveis/Secretaria de Vigilância em Saúde, Ministério da Saúde (DEVIT/SVS-MS), Brasília, Distrito Federal, Brazil.

Carlos F Campelo de Albuquerque (CF)

Organização Pan-Americana da Saúde/Organização Mundial da Saúde (OPAS/OMS), Brasília-DF, Brazil.

Marcio R T Nunes (MRT)

Center for Technological Innovations, Evandro Chagas Institute, Ministry of Health, Ananindeua, Pará, Brazil.

Ester Cerdeira Sabino (EC)

Instituto de Medicina Tropical, Universidade de São Paulo, São Paulo, Brazil.

Nicholas Loman (N)

Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK.

Felipe Gomes Naveca (FG)

Laboratório de Ecologia de Doenças Transmissíveis na Amazônia, Instituto Leônidas e Maria Deane, Fiocruz, Manaus, Brazil.

Oliver G Pybus (OG)

Department of Zoology, University of Oxford, Oxford OX1 3PS, UK. Electronic address: oliver.pybus@zoo.ox.ac.uk.

Luiz Carlos Alcantara (LC)

Laboratório de Flavivírus, Instituto Oswaldo Cruz Fiocruz, Rio de Janeiro, Brazil; Laboratório de Genética Celular e Molecular, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address: luiz.alcantara@ioc.fiocruz.br.

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Classifications MeSH

questionsmedicales.fr › Régions géographiques › Amériques › Amérique du Sud › Brésil › Genomic and Epidemiological Surveillance of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Surveillance épidémiologique › Genomic and Epidemiological Surveillance of...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Genomic and Epidemiological Surveillance of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genomic and Epidemiological Surveillance of...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Flaviviridae › Flavivirus › Virus Zika › Genomic and Epidemiological Surveillance of...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Flaviviridae › Infections à flavivirus › Infection par le virus Zika › Genomic and Epidemiological Surveillance of...