A High-Throughput Screening Identifies MICU1 Targeting Compounds.

Calcium-Binding Proteins / metabolism Cation Transport Proteins / metabolism HeLa Cells High-Throughput Screening Assays / methods Humans Mitochondrial Membrane Transport Proteins / metabolism Models, Molecular
HTS MCU MICU1 active compounds high-throughput screening mitochondrial calcium uniporter mitochondrial calcium uptake molecular modeling small molecules

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
18 02 2020
Historique:
received: 04 11 2019
revised: 08 01 2020
accepted: 22 01 2020
entrez: 21 2 2020
pubmed: 23 2 2020
medline: 10 3 2021
Statut: ppublish

Résumé

Mitochondrial Ca

Identifiants

DOI: 10.1016/j.celrep.2020.01.081 PMID: 32075766 PMC: PMC7034061
pubmed: 32075766
pii: S2211-1247(20)30115-7
doi: 10.1016/j.celrep.2020.01.081
pmc: PMC7034061
pii:
doi:

Substances chimiques

Calcium-Binding Proteins 0
Cation Transport Proteins 0
MICU1 protein, human 0
Mitochondrial Membrane Transport Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2321-2331.e6

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests B.J., C.B., V.T.-E., D.H., B.O., S.S., G.M., and M.F. are employees of Novartis Pharma AG, and some are also shareholders of Novartis.

Auteurs

Giulia Di Marco (G)

Department of Biomedical Sciences, University of Padua, 35131 Padua, Italy.

Francesca Vallese (F)

Department of Biomedical Sciences, University of Padua, 35131 Padua, Italy.

Benjamin Jourde (B)

Novartis Institutes for Biomedical Research, Novartis Campus, 4056 Basel, Switzerland.

Christian Bergsdorf (C)

Novartis Institutes for Biomedical Research, Novartis Campus, 4056 Basel, Switzerland.

Mattia Sturlese (M)

Molecular Modeling Section, Department of Pharmaceutical and Pharmacological Sciences, University of Padua, 35131 Padua, Italy.

Agnese De Mario (A)

Department of Biomedical Sciences, University of Padua, 35131 Padua, Italy.

Valerie Techer-Etienne (V)

Novartis Institutes for Biomedical Research, Novartis Campus, 4056 Basel, Switzerland.

Dorothea Haasen (D)

Novartis Institutes for Biomedical Research, Novartis Campus, 4056 Basel, Switzerland.

Berndt Oberhauser (B)

Novartis Institutes for Biomedical Research, Novartis Campus, 4056 Basel, Switzerland.

Simone Schleeger (S)

Novartis Institutes for Biomedical Research, Novartis Campus, 4056 Basel, Switzerland.

Giulia Minetti (G)

Novartis Institutes for Biomedical Research, Novartis Campus, 4056 Basel, Switzerland.

Stefano Moro (S)

Molecular Modeling Section, Department of Pharmaceutical and Pharmacological Sciences, University of Padua, 35131 Padua, Italy.

Rosario Rizzuto (R)

Department of Biomedical Sciences, University of Padua, 35131 Padua, Italy.

Diego De Stefani (D)

Department of Biomedical Sciences, University of Padua, 35131 Padua, Italy.

Mara Fornaro (M)

Novartis Institutes for Biomedical Research, Novartis Campus, 4056 Basel, Switzerland. Electronic address: mara.fornaro@novartis.com.

Cristina Mammucari (C)

Department of Biomedical Sciences, University of Padua, 35131 Padua, Italy. Electronic address: cristina.mammucari@unipd.it.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Protéines de liaison au calcium › A High-Throughput Screening Identifies MICU1...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs de cations › A High-Throughput Screening Identifies MICU1...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HeLa › A High-Throughput Screening Identifies MICU1...
questionsmedicales.fr › Techniques d'investigation › Tests de criblage à haut débit › A High-Throughput Screening Identifies MICU1...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A High-Throughput Screening Identifies MICU1...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Protéines de transport de la membrane mitochondriale › A High-Throughput Screening Identifies MICU1...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › A High-Throughput Screening Identifies MICU1...