Association between occupational solvent exposure and cognitive performance in the French CONSTANCES study.
Aged
Cognition Disorders
/ chemically induced
Cross-Sectional Studies
Female
France
/ epidemiology
Humans
Male
Middle Aged
Neuropsychological Tests
Occupational Diseases
/ chemically induced
Occupational Exposure
/ adverse effects
Regression Analysis
Sex Distribution
Solvents
/ adverse effects
Surveys and Questionnaires
cognition
occupational exposure
solvent
women
working conditions
Journal
Occupational and environmental medicine
ISSN: 1470-7926
Titre abrégé: Occup Environ Med
Pays: England
ID NLM: 9422759
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
07
08
2019
revised:
22
01
2020
accepted:
27
01
2020
pubmed:
23
2
2020
medline:
24
6
2020
entrez:
21
2
2020
Statut:
ppublish
Résumé
The objective of this study was to evaluate the association between occupational exposure to solvents and cognitive performance in middle-aged and early-ageing participants, taking into account the working environment. In the French Cohorte des consultants des Centres d'examens de santé (CONSTANCES) cohort, 41 854 participants aged 45- Men had a greater risk of global cognitive impairment when they were exposed to gasoline (relative risk (RR)=1.12, 95% CI 1.03 to 1.22), white spirit (RR=1.14, 95% CI 1.05 to 1.25) or cellulosic thinner (RR=1.17, 95% CI 1.06 to 1.31) at the workplace, even after adjusting for confounders. Women exposed to white spirit or exposed for more than 20 years had poorer global cognitive performance. These findings strengthen our understanding of the detrimental effect of solvent exposure on cognitive health not only in men but also in women for the first time, in a large general population middle-aged and early-ageing sample from France, taking into account working conditions.
Identifiants
pubmed: 32075885
pii: oemed-2019-106132
doi: 10.1136/oemed-2019-106132
pmc: PMC7079188
doi:
Substances chimiques
Solvents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
223-230Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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