IRF5 Promotes Influenza Virus-Induced Inflammatory Responses in Human Induced Pluripotent Stem Cell-Derived Myeloid Cells and Murine Models.
Adaptive Immunity
/ physiology
Animals
Disease Models, Animal
Host-Pathogen Interactions
/ immunology
Humans
Immunity, Innate
/ physiology
Induced Pluripotent Stem Cells
/ immunology
Influenza A virus
/ immunology
Influenza, Human
/ immunology
Interferon Regulatory Factors
/ immunology
Interferon Type I
/ metabolism
Lung
/ virology
Macrophages
/ virology
Mice
Orthomyxoviridae Infections
/ virology
Virus Replication
/ physiology
IRF5
dendritic cells
iPSCs
inflammation
influenza
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
16 04 2020
16 04 2020
Historique:
received:
22
01
2020
accepted:
12
02
2020
pubmed:
23
2
2020
medline:
21
10
2020
entrez:
21
2
2020
Statut:
epublish
Résumé
Recognition of influenza A virus (IAV) by the innate immune system triggers pathways that restrict viral replication, activate innate immune cells, and regulate adaptive immunity. However, excessive innate immune activation can exaggerate disease. The pathways promoting excessive activation are incompletely understood, with limited experimental models to investigate the mechanisms driving influenza virus-induced inflammation in humans. Interferon regulatory factor 5 (IRF5) is a transcription factor that plays important roles in the induction of cytokines after viral sensing. In an
Identifiants
pubmed: 32075938
pii: JVI.00121-20
doi: 10.1128/JVI.00121-20
pmc: PMC7163152
pii:
doi:
Substances chimiques
IRF5 protein, human
0
Interferon Regulatory Factors
0
Interferon Type I
0
Irf5 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L018942/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT098051
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 207503/Z/17/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2020 Forbester et al.
Références
PLoS One. 2013 Aug 12;8(8):e71098
pubmed: 23951090
J Virol. 2007 Mar;81(6):2758-68
pubmed: 17215281
J Med Virol. 2001 Jul;64(3):262-8
pubmed: 11424113
Front Immunol. 2018 Jan 08;8:1935
pubmed: 29358940
J Immunol. 2004 Jul 15;173(2):721-5
pubmed: 15240656
Eur J Immunol. 2013 Oct;43(10):2613-25
pubmed: 23857287
J Biol Chem. 2005 Jun 3;280(22):21078-90
pubmed: 15805103
Nature. 2005 Apr 7;434(7034):772-7
pubmed: 15800576
J Exp Med. 2008 Jul 7;205(7):1621-34
pubmed: 18591406
PLoS Pathog. 2013 Jan;9(1):e1003118
pubmed: 23300459
J Biol Chem. 2017 Dec 29;292(52):21291-21303
pubmed: 29046356
Nat Commun. 2014 May 21;5:3864
pubmed: 24844667
PLoS Pathog. 2011 Jan 06;7(1):e1001246
pubmed: 21253574
Blood. 2002 Oct 15;100(8):2858-66
pubmed: 12351396
Cell Mol Immunol. 2016 Nov;13(6):711-721
pubmed: 27818489
Inflamm Res. 2017 Apr;66(4):283-302
pubmed: 27744631
J Biol Chem. 2005 Apr 29;280(17):17005-12
pubmed: 15695821
J Immunol. 2004 Mar 1;172(5):2731-8
pubmed: 14978070
J Immunol. 2008 Feb 15;180(4):2562-72
pubmed: 18250467
Blood. 2010 Jun 3;115(22):4421-30
pubmed: 20237317
J Exp Med. 2016 Dec 12;213(13):2861-2870
pubmed: 27864467
Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3402-7
pubmed: 17360658
Nature. 2005 Mar 10;434(7030):243-9
pubmed: 15665823
J Clin Invest. 1998 Feb 1;101(3):643-9
pubmed: 9449698
Nucleic Acids Res. 2018 Mar 16;46(5):2509-2520
pubmed: 29361124
Cell Stem Cell. 2016 May 5;18(5):573-86
pubmed: 27152442
Sci Immunol. 2017 Jul 7;2(13):
pubmed: 28783704
J Exp Med. 2020 Feb 3;217(2):
pubmed: 31819956
Science. 2014 Mar 7;343(6175):1246980
pubmed: 24604203
Am J Pathol. 2013 Apr;182(4):1308-21
pubmed: 23395090
Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17432-7
pubmed: 25326418
Nat Med. 2006 Oct;12(10):1203-7
pubmed: 16964257
PLoS Pathog. 2016 Jul 20;12(7):e1005754
pubmed: 27438481
Science. 2015 Apr 24;348(6233):448-53
pubmed: 25814066
Nat Commun. 2017 Apr 25;8:15013
pubmed: 28440293
PLoS Genet. 2015 Apr 13;11(4):e1005111
pubmed: 25874939
J Virol. 2014 Oct;88(19):11007-21
pubmed: 25031348
Transl Res. 2016 Jan;167(1):167-82
pubmed: 26207886
PLoS Pathog. 2011 Feb 03;7(2):e1001271
pubmed: 21304882
Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10118-10123
pubmed: 30217896
Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13910-5
pubmed: 23918369
J Innate Immun. 2017;9(2):145-161
pubmed: 27811478
Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):E898-904
pubmed: 22431588
J Exp Med. 2003 Oct 20;198(8):1237-42
pubmed: 14568982
Mucosal Immunol. 2012 May;5(3):258-66
pubmed: 22294047
EMBO Rep. 2015 Sep;16(9):1203-18
pubmed: 26265006
PLoS One. 2015 May 06;10(5):e0124307
pubmed: 25946027
J Immunol. 2011 Nov 1;187(9):4501-8
pubmed: 21957149
Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17438-43
pubmed: 25326420
Mol Cell Biol. 2002 Aug;22(16):5721-40
pubmed: 12138184
Front Immunol. 2016 Mar 14;7:88
pubmed: 27014268
Immunology. 2018 May;154(1):3-20
pubmed: 29313948
Methods. 2016 Mar 1;96:85-96
pubmed: 26608109
Nat Rev Immunol. 2014 May;14(5):315-28
pubmed: 24762827
Int J Biochem Cell Biol. 2018 Jun;99:38-42
pubmed: 29578052
Eur J Immunol. 2001 Sep;31(9):2566-73
pubmed: 11536154