Predictors of health-related quality of life among military HIV-infected individuals.
HIV
Health-related quality of life
Highly active antiretroviral therapy
Mental component summary scores
Physical component summary scores
Journal
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
ISSN: 1573-2649
Titre abrégé: Qual Life Res
Pays: Netherlands
ID NLM: 9210257
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
accepted:
01
02
2020
pubmed:
23
2
2020
medline:
28
7
2020
entrez:
21
2
2020
Statut:
ppublish
Résumé
To determine long-term predictors of health-related quality of life (HRQOL) and evaluate the treatment effect of highly active antiretroviral therapy (HAART) on HRQOL in the US Military HIV Natural History Study (NHS) cohort. Participants were a nested cohort of the NHS who responded to the Rand Short Form 36 questionnaire administered from 2006 to 2010. Physical component summary scores (PCS) and mental component summary scores (MCS) were computed using standard algorithms. HAART-status was categorized as non-protease inhibitor-based (NPI-HAART), protease inhibitor-based (PI-HAART), HAART-naïve, or off-HAART. Mixed linear random effects models were used to estimate changes in PCS and MCS over time for treatment and covariates (including CD4 count, HIV viral load, medical and mental comorbidities). Eight hundred and twelve participants met the inclusion criteria. There was no difference in PCS or MCS between those on PI-HAART compared to NPI-HAART. Significant predictors of PCS were CD4 count < 200 cells/mm HRQOL was significantly affected by low CD4 count, medical and mental comorbidities. Addressing these modifiable factors would be expected to improve the physical and mental HRQOL of the cohort. Our study did not find any treatment benefit of NPI-HAART over PI-HAART on HRQOL in the long term.
Identifiants
pubmed: 32076926
doi: 10.1007/s11136-020-02441-5
pii: 10.1007/s11136-020-02441-5
pmc: PMC7299773
mid: NIHMS1564219
doi:
Substances chimiques
Protease Inhibitors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1855-1869Subventions
Organisme : NIAID NIH HHS
ID : Y01 AI005072
Pays : United States
Organisme : NIAID NIH HHS
ID : Y01 I12012001
Pays : United States
Organisme : National Institute of Allergy and Infectious Diseases
ID : Y1-AI-5072
Investigateurs
S De Leon
(S)
S Merritt
(S)
T Merritt
(T)
J Okulicz
(J)
T Sjoberg
(T)
C Baker
(C)
S Chambers
(S)
R Colombo
(R)
T Ferguson
(T)
A Kunz
(A)
C Schofield
(C)
M Stein
(M)
J Powers
(J)
E Tramont
(E)
S Banks
(S)
K Kronmann
(K)
T Lalani
(T)
R Tant
(R)
T Warkentien
(T)
S Cammarata
(S)
N Kirkland
(N)
R Maves
(R)
G Utz
(G)
M Price
(M)
B Agan
(B)
X Chu
(X)
C Estupigan
(C)
W Horton
(W)
H Hsieh
(H)
A Noiman
(A)
E Parmelee
(E)
D Tribble
(D)
X Wang
(X)
S Won
(S)
T Crowell
(T)
S Peel
(S)
I Barahona
(I)
J Blaylock
(J)
C Decker
(C)
A Ganesan
(A)
R Ressner
(R)
D Wallace
(D)
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