Steroids Inhibit Eosinophil Accumulation and Downregulate Hematopoietic Chemotaxic Prostaglandin D
Adrenal Cortex Hormones
/ therapeutic use
Adult
Aged
Asthma, Aspirin-Induced
/ drug therapy
Cell Migration Inhibition
Cyclooxygenase Inhibitors
/ adverse effects
Down-Regulation
/ drug effects
Eosinophil Peroxidase
/ metabolism
Eosinophils
/ drug effects
Female
Humans
Intramolecular Oxidoreductases
/ metabolism
Male
Middle Aged
Nasal Polyps
/ drug therapy
Receptors, Immunologic
/ metabolism
Receptors, Prostaglandin
/ metabolism
DP2
aspirin-exacerbated respiratory disease
eosinophil
nasal polyp
prostaglandin D2
prostaglandin E2
Journal
Ear, nose, & throat journal
ISSN: 1942-7522
Titre abrégé: Ear Nose Throat J
Pays: United States
ID NLM: 7701817
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
pubmed:
23
2
2020
medline:
17
12
2021
entrez:
21
2
2020
Statut:
ppublish
Résumé
Aspirin-exacerbated respiratory disease (AERD) is characterized by eosinophilic rhinosinusitis, nasal polyposis, aspirin sensitivity, and asthma. Among 37 patients undergoing endoscopic sinus surgery, 28 received systemic steroids preoperatively. Nasal polyps were harvested from all 37 patients. After routine processing of paraffin sections, immunohistochemistry was performed using specific antibodies for HPGDS, eosinophil peroxidase (EPX), and DP2. Expression of HPGDS, DP2, and EPX by eosinophils was higher and more frequent in patients with non-preoperative steroid therapy. Likewise, HPGDS and DP2 were highly expressed in activated eosinophils in the nasal polyps, but not in normal eosinophils. This study provides clear evidence that systemic steroid therapy inhibits eosinophil activation and decreases HPGDS and DP2 expression in patients with AERD, indicating a reduction in prostaglandin D
Sections du résumé
BACKGROUND
BACKGROUND
Aspirin-exacerbated respiratory disease (AERD) is characterized by eosinophilic rhinosinusitis, nasal polyposis, aspirin sensitivity, and asthma.
MATERIALS AND METHODS
METHODS
Among 37 patients undergoing endoscopic sinus surgery, 28 received systemic steroids preoperatively. Nasal polyps were harvested from all 37 patients. After routine processing of paraffin sections, immunohistochemistry was performed using specific antibodies for HPGDS, eosinophil peroxidase (EPX), and DP2.
RESULTS
RESULTS
Expression of HPGDS, DP2, and EPX by eosinophils was higher and more frequent in patients with non-preoperative steroid therapy. Likewise, HPGDS and DP2 were highly expressed in activated eosinophils in the nasal polyps, but not in normal eosinophils.
CONCLUSION AND SIGNIFICANCE
CONCLUSIONS
This study provides clear evidence that systemic steroid therapy inhibits eosinophil activation and decreases HPGDS and DP2 expression in patients with AERD, indicating a reduction in prostaglandin D
Identifiants
pubmed: 32077309
doi: 10.1177/0145561320902858
doi:
Substances chimiques
Adrenal Cortex Hormones
0
Cyclooxygenase Inhibitors
0
Receptors, Immunologic
0
Receptors, Prostaglandin
0
Eosinophil Peroxidase
EC 1.11.1.-
Intramolecular Oxidoreductases
EC 5.3.-
PTGDS protein, human
EC 5.3.-
prostaglandin D2 receptor
XZF106QU24
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM