Is drug consumption correlated with benign paroxysmal positional vertigo (BPPV) recurrence?
BPPV
Benign paroxysmal positional vertigo
Drugs
Recurrence
Recurrent positional vertigo
Vertigo
Journal
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
ISSN: 1434-4726
Titre abrégé: Eur Arch Otorhinolaryngol
Pays: Germany
ID NLM: 9002937
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
04
10
2019
accepted:
06
02
2020
pubmed:
23
2
2020
medline:
28
4
2021
entrez:
21
2
2020
Statut:
ppublish
Résumé
Benign paroxysmal positional vertigo (BPPV) is the most common cause of peripheral vertigo and its recurrence is fairly common. Several studies correlated the pathophysiological role of different comorbidities-such as diabetes, osteoporosis, vascular, psychiatric and autoimmune diseases-in the development and recurrence of BPPV. The aim of this study is to analyse the pharmacological history of patients with idiopathic BPPV in relation to the risk of developing recurrence. Data regarding 715 patients aged 12 to 87 years (62.7 ± 14) with non-traumatic BPPV were retrospectively evaluated. These refer to the Vestibular Service, day clinic, and were collected over a 4-year period, between 2014 and 2018. Recurrence of BPPV was observed in 220/715 patients (30.76%). A statistically significant correlation (p < 0.006) between recurrence and drug consumption was observed for SNC agents (p = 0.0001), vitamin D (p = 0.0005), PPI (p = 0.0007), thyroid hormones (p = 0.0011), and antihypertensives in single use (p = 0.0031). On the contrary, cholesterol-lowering statin drugs, hypoglycaemic agents, antiplatelet medication, estroprogestins and combination of two or more antihypertensives did not show significant correlation. Specific classes of drugs are significantly associated with recurrence: antihypertensive therapy with a singular agent, central nervous system agents, PPIs, vitamin D and thyroid hormones. On the other hand, the lack of correlation between some drugs and recurrence could be linked to the effectiveness of therapy in controlling hypertension, dyslipidaemia and diabetes. Pharmacological history is an essential tool to identify patients at risk of BPPV recurrence.
Sections du résumé
BACKGROUND
BACKGROUND
Benign paroxysmal positional vertigo (BPPV) is the most common cause of peripheral vertigo and its recurrence is fairly common. Several studies correlated the pathophysiological role of different comorbidities-such as diabetes, osteoporosis, vascular, psychiatric and autoimmune diseases-in the development and recurrence of BPPV. The aim of this study is to analyse the pharmacological history of patients with idiopathic BPPV in relation to the risk of developing recurrence.
METHODS
METHODS
Data regarding 715 patients aged 12 to 87 years (62.7 ± 14) with non-traumatic BPPV were retrospectively evaluated. These refer to the Vestibular Service, day clinic, and were collected over a 4-year period, between 2014 and 2018.
RESULTS
RESULTS
Recurrence of BPPV was observed in 220/715 patients (30.76%). A statistically significant correlation (p < 0.006) between recurrence and drug consumption was observed for SNC agents (p = 0.0001), vitamin D (p = 0.0005), PPI (p = 0.0007), thyroid hormones (p = 0.0011), and antihypertensives in single use (p = 0.0031). On the contrary, cholesterol-lowering statin drugs, hypoglycaemic agents, antiplatelet medication, estroprogestins and combination of two or more antihypertensives did not show significant correlation.
CONCLUSION
CONCLUSIONS
Specific classes of drugs are significantly associated with recurrence: antihypertensive therapy with a singular agent, central nervous system agents, PPIs, vitamin D and thyroid hormones. On the other hand, the lack of correlation between some drugs and recurrence could be linked to the effectiveness of therapy in controlling hypertension, dyslipidaemia and diabetes. Pharmacological history is an essential tool to identify patients at risk of BPPV recurrence.
Identifiants
pubmed: 32078026
doi: 10.1007/s00405-020-05855-6
pii: 10.1007/s00405-020-05855-6
doi:
Substances chimiques
Pharmaceutical Preparations
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1609-1616Références
Kim JS, Zee D (2014) Clinical practice benign paroxysmal positional vertigo. New Engl J Med 370(12):1138–1147
pubmed: 24645946
doi: 10.1056/NEJMcp1309481
Palmeri R, Kumar A (2019) Benign paroxysmal positional vertigo (BPPV). Treasure Island (FL): StatPearls Publishing. Available at: https://www.ncbi.nlm.nih.gov/books/NBK470308 . Accessed Jan 2019
Faralli M, Ricci G, Molini E et al (2006) Paroxysmal positional vertigo: the role of age as a prognostic factor. Acta Otorhinolaryngol Ital 26(1):25–31
pubmed: 18383754
pmcid: 2639952
Von Brevern M, Seelig T, Neuhauser H et al (2004) Benign paroxysmal positional vertigo predominantly affects the right labyrinth. J Neurol Neurosurg Psychiatry 75(10):1487–1488
doi: 10.1136/jnnp.2003.031500
Bertholon P, Tringali S, Faye MB et al (2006) Prospective study of positional nystagmus in 100 consecutive patients. Ann Otol Rhinol Laryngol 115:587–594
pubmed: 16944657
doi: 10.1177/000348940611500804
Steenerson RL, Cronin GW, Marbach PM (2005) Effectiveness of treatment techniques in 923 cases of benign paroxysmal positional vertigo. Laryngoscope 115:226–231
pubmed: 15689740
doi: 10.1097/01.mlg.0000154723.55044.b5
Barany R (1921) Diagnose von krankheitserscheinungen im. Bereiche des otolithenapparates [in German]. Acta Otolaryngol 2:434–437
doi: 10.3109/00016482009123103
Schuknecht HF (1969) Cupulolithiasis. Arch Otolaryngol 90:765–778
pubmed: 5353084
doi: 10.1001/archotol.1969.00770030767020
Parnes LS, McClure JA (1992) Free-floating endolymph particles: a new operative finding during posterior semicircular canal occlusion. Laryngoscope 102:988–992
pubmed: 1518363
doi: 10.1288/00005537-199209000-00006
Talaat HS, Abuhadied G, Talaat AS et al (2015) Low bone mineral density and vitamin D deficiency in patients with benign positional paroxysmal vertigo. Eur Arch Otorhinolaryngol 272:2249
pubmed: 24973969
doi: 10.1007/s00405-014-3175-3
Moon SY, Kim JS, Kim BK et al (2006) Clinical characteristics of benign paroxysmal positional vertigo in Korea: a multicenter study. J Korean Med Sci 21:539–543
pubmed: 16778402
pmcid: 2729964
doi: 10.3346/jkms.2006.21.3.539
Hughes CA, Proctor L (1997) Benign paroxysmal positional vertigo. Laryngoscope 107(5):607
pubmed: 9149161
doi: 10.1097/00005537-199705000-00010
Dispenza F, De Stefano A, Mathur N et al (2011) Benign paroxysmal positional vertigo following whiplash injury: a myth or a reality? Am J Otolaryngol 32(5):376
pubmed: 20832902
doi: 10.1016/j.amjoto.2010.07.009
Lee NH, Ban JH, Lee KC et al (2010) Benign paroxysmal positional vertigo secondary to inner ear disease. Otolaryngol Head Neck Surg 143(3):413
pubmed: 20723780
doi: 10.1016/j.otohns.2010.06.905
De la Meilleure G, Dehaene I, Depondt M et al (1996) Benign paroxysmal positional vertigo of the horizontal canal. J Neurol Neurosurg Psychiatry 60(1):68–71
pubmed: 8558155
pmcid: 486192
doi: 10.1136/jnnp.60.1.68
Zucca G, Valli S, Valli P et al (1998) Why do benign paroxysmal positional vertigo episodes recover spontaneously? J Vestib Res 8(4):325–329
pubmed: 9652482
doi: 10.3233/VES-1998-8404
Brandt T, Huppert D, Hecht J et al (2006) Benign paroxysmal positioning vertigo: a long-term follow-up (6–17 years) of 125 patients. Acta Otolaryngol 126(2):160–163
pubmed: 16428193
doi: 10.1080/00016480500280140
Ahn SK, Jeon SY, Kim JP et al (2011) Clinical characteristics and treatment of benign paroxysmal positional vertigo after traumatic brain injury. J Trauma 70(2):442–446
pubmed: 20489667
doi: 10.1097/TA.0b013e3181d0c3d9
Choi SJ, Lee JB, Lim HJ et al (2012) Clinical features of recurrent or persistent benign paroxysmal positional vertigo. Otolaryngol Head Neck Surg 147(5):919–924
pubmed: 22807487
doi: 10.1177/0194599812454642
Yoda S, Cureoglu S, Yildirim-Baylan M et al (2011) Association between type 1 diabetes mellitus and deposits in the semicircular canals. Otolaryngol Head Neck Surg 145:458–462
pubmed: 21572081
doi: 10.1177/0194599811407610
Jang YS, Kang MK (2009) Relationship between bone mineral density and clinical features in women with idiopathic benign paroxysmal positional vertigo. Otol Neurotol 30:95–100
pubmed: 19008769
doi: 10.1097/MAO.0b013e31818f5777
Jeong SH, Choi SH, Kim JY et al (2009) Osteopenia and osteoporosis in idiopathic benign positional vertigo. Neurology 72(12):1069–1076
pubmed: 19307540
doi: 10.1212/01.wnl.0000345016.33983.e0
Faralli M, Ricci G, Molini E et al (2006) Paroxysmal positional vertigo: the role of age as a prognostic factor. Acta Otorhinolaryngol Ital 26:25–31
pubmed: 18383754
pmcid: 2639952
Eckhardt-Henn A, Best C, Bense S et al (2006) Psychiatric comorbidity in different organic vertigo syndromes. J Neurol 255:420–428
doi: 10.1007/s00415-008-0697-x
Modugno GC, Pirodda A, Ferri GG et al (2006) A relationship between autoimmune thyroiditis and benign paroxysmal positional vertigo? Med Hypotheses 54:614–615
doi: 10.1054/mehy.1999.0905
Picciotti PM, Lucidi D, De Corso E et al (2006) Comorbidities and recurrence of benign paroxysmal positional vertigo: personal experience. Int J Audiol 55(5):279–284
doi: 10.3109/14992027.2016.1143981
De Stefano A, Dispenza F, Suarez H et al (2014) A multicenter observational study on the role of comorbidities in the recurrent episodes of benign paroxysmal positional vertigo. Auris Nasus Larynx 41:31–36
pubmed: 23932347
doi: 10.1016/j.anl.2013.07.007
Messina A, Casani AP, Manfrini M et al (2017) Italian survey on benign paroxysmal positional vertigo. Acta Otorhinolaryngol Ital 37:328–335
pubmed: 28872163
pmcid: 5584106
Pellacani A, Brunner HR, Nussberger J (1994) Plasma kinins increase after angiotensin-converting enzyme inhibition in human subjects. Clin Sci 87:567–574
pubmed: 7874846
doi: 10.1042/cs0870567
Marceau F, Hess JF, Bachvarov DR (1998) The B1 receptors for kinins. Pharmacol Rev 50:357–386
pubmed: 9755287
Shi X (2011) Physiopathology of the cochlear microcirculation. Hear Res 282(1–2):10–24
pubmed: 21875658
pmcid: 3608480
doi: 10.1016/j.heares.2011.08.006
Ferrari S, Monzani D, Baraldi S et al (2014) Vertigo ‘‘in the pink:’’ the impact of female gender on psychiatric–psychosomatic comorbidity in benign paroxysmal positional vertigo patients. Psychosomatics 55:280–288
pubmed: 23756120
doi: 10.1016/j.psym.2013.02.005
Warninghoff JC, Bayer O, Ferrari U et al (2009) Co-morbidities of vertiginous diseases. BMC Neurol 7(9):29
doi: 10.1186/1471-2377-9-29
Serif SK, Cengiz A, Umit SC et al (2017) The evaluation of anxiety and panic agarophobia scores in patients with benign paroxysmal positional vertigo on initial presentation and at the follow-up visit. Acta Otolaryngol 137:5485–5489
Jung HJ, Koo JW, Kim CS et al (2012) Anxiolytics reduce residual dizziness after successful canalith repositioning maneuvers in benign paroxysmal positional vertigo. Acta Otolaryngol 132(3):277–284
pubmed: 22201336
doi: 10.3109/00016489.2011.637179
Strupp M, Arbusow V, Brandt T (2001) Exercise and drug therapy alter recovery from labyrinth lesion in humans. Ann N Y Acad Sci 942(79):11
Modugno GC, Pirodda A, Ferri GG et al (2000) A relationship between autoimmune thyroiditis and benign paroxysmal positional vertigo? Med Hypotheses 54:614–615
pubmed: 10859648
doi: 10.1054/mehy.1999.0905
Talaat HS, Kabel AM, Khaliel LH et al (2016) Reduction of recurrence rate of benign paroxysmal positional vertigo by treatment of severe vitamin D deficiency. Auris Nasus Larynx 43(3):237–241
pubmed: 26386496
doi: 10.1016/j.anl.2015.08.009
O'Connell MB, Madden DM, Murray AM et al (2005) Effects of proton pump inhibitors on calcium carbonate absorption in women: a randomized crossover trial. Am J Med 118:778–781
pubmed: 15989913
doi: 10.1016/j.amjmed.2005.02.007
Ivanovich P, Fellows H, Rich C (1967) The absorption of calcium carbonate. Ann Intern Med 66:917–923
pubmed: 6025232
doi: 10.7326/0003-4819-66-5-917
Jansen JB, Klinkenberg-Knol EC, Meuwissen SG et al (1990) Effect of long-term treatment with omeprazole on serum gastrin and serum group A and C pepsinogens in patients with reflux esophagitis. Gastroenterology 99:621–628
pubmed: 2199288
doi: 10.1016/0016-5085(90)90946-X
Lindsay R, Nieves J, Formica C et al (1997) Randomised controlled study of effect of parathyroid hormone on vertebral-bone mass and fracture incidence among postmenopausal women on oestrogen with osteoporosis. Lancet 350:550–555
pubmed: 9284777
doi: 10.1016/S0140-6736(97)02342-8
Ogun OA, Büki B, Cohn ES et al (2014) Menopause and benign paroxysmal positional vertigo. Menopause 21(8):886–889
pubmed: 24496089
pmcid: 4110114
doi: 10.1097/GME.0000000000000190