Genetic Susceptibility for Atrial Fibrillation in Patients Undergoing Atrial Fibrillation Ablation.

Aged Atrial Fibrillation / genetics Body Surface Potential Mapping / methods Catheter Ablation Female Follow-Up Studies Genetic Predisposition to Disease Humans Male Middle Aged Multifactorial Inheritance / genetics Polymorphism, Single Nucleotide Preoperative Period Prognosis Prospective Studies Recurrence
atrial fibrillation genetic variation genetics phenotype pulmonary veins

Journal

Circulation. Arrhythmia and electrophysiology
ISSN: 1941-3084
Titre abrégé: Circ Arrhythm Electrophysiol
Pays: United States
ID NLM: 101474365

Informations de publication

Date de publication:
03 2020
Historique:
pubmed: 23 2 2020
medline: 20 8 2020
entrez: 21 2 2020
Statut: ppublish

Résumé

Ablation is a widely used therapy for atrial fibrillation (AF); however, arrhythmia recurrence and repeat procedures are common. Studies examining surrogate markers of genetic susceptibility to AF, such as family history and individual AF susceptibility alleles, suggest these may be associated with recurrence outcomes. Accordingly, the aim of this study was to test the association between AF genetic susceptibility and recurrence after ablation using a comprehensive polygenic risk score for AF. Ten centers from the AF Genetics Consortium identified patients who had undergone de novo AF ablation. AF genetic susceptibility was measured using a previously described polygenic risk score (N=929 single-nucleotide polymorphisms) and tested for an association with clinical characteristics and time-to-recurrence with a 3 month blanking period. Recurrence was defined as >30 seconds of AF, atrial flutter, or atrial tachycardia. Multivariable analysis adjusted for age, sex, height, body mass index, persistent AF, hypertension, coronary disease, left atrial size, left ventricular ejection fraction, and year of ablation. Four thousand two hundred seventy-six patients were eligible for analysis of baseline characteristics and 3259 for recurrence outcomes. The overall arrhythmia recurrence rate between 3 and 12 months was 44% (1443/3259). Patients with higher AF genetic susceptibility were younger ( Higher AF genetic susceptibility was associated with younger age and fewer clinical risk factors but not recurrence. Arrhythmia recurrence after AF ablation may represent a genetically different phenotype compared to AF susceptibility.

Sections du résumé

BACKGROUND
Ablation is a widely used therapy for atrial fibrillation (AF); however, arrhythmia recurrence and repeat procedures are common. Studies examining surrogate markers of genetic susceptibility to AF, such as family history and individual AF susceptibility alleles, suggest these may be associated with recurrence outcomes. Accordingly, the aim of this study was to test the association between AF genetic susceptibility and recurrence after ablation using a comprehensive polygenic risk score for AF.
METHODS
Ten centers from the AF Genetics Consortium identified patients who had undergone de novo AF ablation. AF genetic susceptibility was measured using a previously described polygenic risk score (N=929 single-nucleotide polymorphisms) and tested for an association with clinical characteristics and time-to-recurrence with a 3 month blanking period. Recurrence was defined as >30 seconds of AF, atrial flutter, or atrial tachycardia. Multivariable analysis adjusted for age, sex, height, body mass index, persistent AF, hypertension, coronary disease, left atrial size, left ventricular ejection fraction, and year of ablation.
RESULTS
Four thousand two hundred seventy-six patients were eligible for analysis of baseline characteristics and 3259 for recurrence outcomes. The overall arrhythmia recurrence rate between 3 and 12 months was 44% (1443/3259). Patients with higher AF genetic susceptibility were younger (
CONCLUSIONS
Higher AF genetic susceptibility was associated with younger age and fewer clinical risk factors but not recurrence. Arrhythmia recurrence after AF ablation may represent a genetically different phenotype compared to AF susceptibility.

Identifiants

DOI: 10.1161/CIRCEP.119.007676 PMID: 32078373 PMC: PMC7080569
pubmed: 32078373
doi: 10.1161/CIRCEP.119.007676
pmc: PMC7080569
mid: NIHMS1562325
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e007676

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL139731
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL138737
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142893
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL116280
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL111314
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL139439
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000445
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024989
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL127704
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002548
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL090620
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL105756
Pays : United States

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Auteurs

M Benjamin Shoemaker (MB)

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (M.B.S., C.S., L.L.R., D.M.C., J.M., Z.Y., Q.W., T.I., P.W., G.M.).

Daniela Husser (D)

Heart Center Leipzig, Department of Electrophysiology, Leipzig Heart Institute, University of Leipzig, Germany (D.H., L.U., P.B., G.H., A.B.).

Carolina Roselli (C)

Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Program in Medical and Population Genetics, Cambridge, MA (C.R., P.E., S.L.).

Meelad Al Jazairi (M)

Department of Cardiology, University of Groningen, University Medical Center Groningen, the Netherlands (M.A.J., J.E.S., B.G., I.C.V.G., M.R.).

Jonathan Chrispin (J)

Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (J.C., H.C.).

Michael Kühne (M)

University Hospital Basel, Switzerland (M.K., S.B., S.A., D.C.).
Cardiovascular Research Institute Basel, University Hospital Basel, Switzerland (M.K., S.B., S.A., D.C.).

Benjamin Neumann (B)

Department of Medicine, University Hospital Munich, Ludwig Maximilians University of Munich, Germany (B.N., R.F., S. Kääb, M.F.S.).

Stacey Knight (S)

Intermountain Heart Institute, Intermountain Medical Center, Murray (S. Knight, V.J.).
Department of Medicine, University of Utah, Salt Lake City (S. Knight).

Han Sun (H)

Department of Quantitative Health Sciences (H.S., J.B.), Lerner Research Institute, Cleveland Clinic, OH.

Sanghamitra Mohanty (S)

Texas Cardiac Arrhythmia Institute, Austin, TX (S.M., A.N.).
Department of Internal Medicine, Dell Medical School, Austin, TX (S.M., A.N.).

Christian Shaffer (C)

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (M.B.S., C.S., L.L.R., D.M.C., J.M., Z.Y., Q.W., T.I., P.W., G.M.).

Sébastien Thériault (S)

Population Health Research Institute, McMaster University, Hamilton, ON, Canada (S.T., D.C.).
Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University, Quebec City, Canada (S.T.).

Lauren Lee Rinke (LL)

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (M.B.S., C.S., L.L.R., D.M.C., J.M., Z.Y., Q.W., T.I., P.W., G.M.).

Joylene E Siland (JE)

Department of Cardiology, University of Groningen, University Medical Center Groningen, the Netherlands (M.A.J., J.E.S., B.G., I.C.V.G., M.R.).

Diane M Crawford (DM)

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (M.B.S., C.S., L.L.R., D.M.C., J.M., Z.Y., Q.W., T.I., P.W., G.M.).

Laura Ueberham (L)

Heart Center Leipzig, Department of Electrophysiology, Leipzig Heart Institute, University of Leipzig, Germany (D.H., L.U., P.B., G.H., A.B.).

Omeed Zardkoohi (O)

Departments of Cardiovascular Medicine and Molecular Cardiology, Heart and Vascular Institute (O.Z., M.C.), Lerner Research Institute, Cleveland Clinic, OH.

Petra Büttner (P)

Heart Center Leipzig, Department of Electrophysiology, Leipzig Heart Institute, University of Leipzig, Germany (D.H., L.U., P.B., G.H., A.B.).

Bastiaan Geelhoed (B)

Department of Cardiology, University of Groningen, University Medical Center Groningen, the Netherlands (M.A.J., J.E.S., B.G., I.C.V.G., M.R.).

Steffen Blum (S)

University Hospital Basel, Switzerland (M.K., S.B., S.A., D.C.).
Cardiovascular Research Institute Basel, University Hospital Basel, Switzerland (M.K., S.B., S.A., D.C.).

Stefanie Aeschbacher (S)

University Hospital Basel, Switzerland (M.K., S.B., S.A., D.C.).
Cardiovascular Research Institute Basel, University Hospital Basel, Switzerland (M.K., S.B., S.A., D.C.).

Jonathan D Smith (JD)

Department of Cellular and Molecular Medicine (J.D.S.), Lerner Research Institute, Cleveland Clinic, OH.

David R Van Wagoner (DR)

Department of Molecular Cardiology (D.R.V.W.), Lerner Research Institute, Cleveland Clinic, OH.

Rebecca Freudling (R)

Department of Medicine, University Hospital Munich, Ludwig Maximilians University of Munich, Germany (B.N., R.F., S. Kääb, M.F.S.).
Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg (R.F., M.M.-N.).

Martina Müller-Nurasyid (M)

Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg (R.F., M.M.-N.).
German Centre for Cardiovascular Research (DZHK), partner site: Munich Heart Alliance, Germany (M.M.-N., S. Kääb, M.F.S.).

Jay Montgomery (J)

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (M.B.S., C.S., L.L.R., D.M.C., J.M., Z.Y., Q.W., T.I., P.W., G.M.).

Zachary Yoneda (Z)

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (M.B.S., C.S., L.L.R., D.M.C., J.M., Z.Y., Q.W., T.I., P.W., G.M.).

Quinn Wells (Q)

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (M.B.S., C.S., L.L.R., D.M.C., J.M., Z.Y., Q.W., T.I., P.W., G.M.).

Tariq Issa (T)

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (M.B.S., C.S., L.L.R., D.M.C., J.M., Z.Y., Q.W., T.I., P.W., G.M.).

Peter Weeke (P)

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (M.B.S., C.S., L.L.R., D.M.C., J.M., Z.Y., Q.W., T.I., P.W., G.M.).

Victoria Jacobs (V)

Intermountain Heart Institute, Intermountain Medical Center, Murray (S. Knight, V.J.).

Isabelle C Van Gelder (IC)

Department of Cardiology, University of Groningen, University Medical Center Groningen, the Netherlands (M.A.J., J.E.S., B.G., I.C.V.G., M.R.).

Gerhard Hindricks (G)

Heart Center Leipzig, Department of Electrophysiology, Leipzig Heart Institute, University of Leipzig, Germany (D.H., L.U., P.B., G.H., A.B.).

John Barnard (J)

Department of Quantitative Health Sciences (H.S., J.B.), Lerner Research Institute, Cleveland Clinic, OH.

Hugh Calkins (H)

Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (J.C., H.C.).

Dawood Darbar (D)

Division of Cardiology, Department of Medicine, University of Illinois Health, Chicago (D.D.).

Greg Michaud (G)

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (M.B.S., C.S., L.L.R., D.M.C., J.M., Z.Y., Q.W., T.I., P.W., G.M.).

Stefan Kääb (S)

Department of Medicine, University Hospital Munich, Ludwig Maximilians University of Munich, Germany (B.N., R.F., S. Kääb, M.F.S.).
German Centre for Cardiovascular Research (DZHK), partner site: Munich Heart Alliance, Germany (M.M.-N., S. Kääb, M.F.S.).

Patrick Ellinor (P)

Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Program in Medical and Population Genetics, Cambridge, MA (C.R., P.E., S.L.).
Massachusetts General Hospital, Cardiac Arrhythmia Service, Boston (P.E., S.L.).

Andrea Natale (A)

Texas Cardiac Arrhythmia Institute, Austin, TX (S.M., A.N.).
Department of Internal Medicine, Dell Medical School, Austin, TX (S.M., A.N.).
Scripps Clinic, Interventional Electrophysiology, San Diego, CA (A.N.).
Division of Cardiology, Stanford University, Palo Alto, CA (A.N.).
Case Western University, Cleveland, OH (A.N.).

Mina Chung (M)

Departments of Cardiovascular Medicine and Molecular Cardiology, Heart and Vascular Institute (O.Z., M.C.), Lerner Research Institute, Cleveland Clinic, OH.

Saman Nazarian (S)

Division of Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia (S.N.).

Michael J Cutler (MJ)

Intermountain Heart Institute, Intermountain Medical Center, Murray, UT (M.J.C.).

Moritz F Sinner (MF)

Department of Medicine, University Hospital Munich, Ludwig Maximilians University of Munich, Germany (B.N., R.F., S. Kääb, M.F.S.).
German Centre for Cardiovascular Research (DZHK), partner site: Munich Heart Alliance, Germany (M.M.-N., S. Kääb, M.F.S.).

David Conen (D)

University Hospital Basel, Switzerland (M.K., S.B., S.A., D.C.).
Cardiovascular Research Institute Basel, University Hospital Basel, Switzerland (M.K., S.B., S.A., D.C.).
Population Health Research Institute, McMaster University, Hamilton, ON, Canada (S.T., D.C.).

Michiel Rienstra (M)

Department of Cardiology, University of Groningen, University Medical Center Groningen, the Netherlands (M.A.J., J.E.S., B.G., I.C.V.G., M.R.).

Andreas Bollmann (A)

Heart Center Leipzig, Department of Electrophysiology, Leipzig Heart Institute, University of Leipzig, Germany (D.H., L.U., P.B., G.H., A.B.).

Dan M Roden (DM)

Animal, Dairy, and Veterinary Sciences, Utah State University, Logan (D.M.R.).

Steven Lubitz (S)

Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Program in Medical and Population Genetics, Cambridge, MA (C.R., P.E., S.L.).
Massachusetts General Hospital, Cardiac Arrhythmia Service, Boston (P.E., S.L.).

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Genetic Susceptibility for Atrial Fibrillation...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Troubles du rythme cardiaque › Fibrillation auriculaire › Genetic Susceptibility for Atrial Fibrillation...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Électrodiagnostic › Électrocardiographie › Vectocardiographie › Cartographie du potentiel de surface corporelle › Genetic Susceptibility for Atrial Fibrillation...
questionsmedicales.fr › Procédures de chirurgie opératoire › Techniques d'ablation › Ablation par radiofréquence › Ablation par cathéter › Genetic Susceptibility for Atrial Fibrillation...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études de suivi › Genetic Susceptibility for Atrial Fibrillation...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Genetic Susceptibility for Atrial Fibrillation...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genetic Susceptibility for Atrial Fibrillation...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Genetic Susceptibility for Atrial Fibrillation...
questionsmedicales.fr › Phénomènes génétiques › Modes de transmission héréditaire › Hérédité multifactorielle › Genetic Susceptibility for Atrial Fibrillation...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Genetic Susceptibility for Atrial Fibrillation...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Soins aux patients › Période périopératoire › Période préopératoire › Genetic Susceptibility for Atrial Fibrillation...
questionsmedicales.fr › Diagnostic › Pronostic › Genetic Susceptibility for Atrial Fibrillation...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Genetic Susceptibility for Atrial Fibrillation...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Récidive › Genetic Susceptibility for Atrial Fibrillation...