Functional and Structural Roles of the Major Facilitator Superfamily Bacterial Multidrug Efflux Pumps.
antimicrobial agents
bacteria
infection
major facilitator superfamily
multidrug resistance
pathogens
sequence motifs
transporters
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
16 Feb 2020
16 Feb 2020
Historique:
received:
27
12
2019
revised:
30
01
2020
accepted:
11
02
2020
entrez:
22
2
2020
pubmed:
23
2
2020
medline:
23
2
2020
Statut:
epublish
Résumé
Pathogenic microorganisms that are multidrug-resistant can pose severe clinical and public health concerns. In particular, bacterial multidrug efflux transporters of the major facilitator superfamily constitute a notable group of drug resistance mechanisms primarily because multidrug-resistant pathogens can become refractory to antimicrobial agents, thus resulting in potentially untreatable bacterial infections. The major facilitator superfamily is composed of thousands of solute transporters that are related in terms of their phylogenetic relationships, primary amino acid sequences, two- and three-dimensional structures, modes of energization (passive and secondary active), and in their mechanisms of solute and ion translocation across the membrane. The major facilitator superfamily is also composed of numerous families and sub-families of homologous transporters that are conserved across all living taxa, from bacteria to humans. Members of this superfamily share several classes of highly conserved amino acid sequence motifs that play essential mechanistic roles during transport. The structural and functional importance of multidrug efflux pumps that belong to the major facilitator family and that are harbored by Gram-negative and -positive bacterial pathogens are considered here.
Identifiants
pubmed: 32079127
pii: microorganisms8020266
doi: 10.3390/microorganisms8020266
pmc: PMC7074785
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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