The Crosstalk between Cardiac Lipotoxicity and Mitochondrial Oxidative Stress in the Cardiac Alterations in Diet-Induced Obesity in Rats.
cardiac fibrosis
cardiac hypertrophy
cardiac lipotoxicity
mitochondrial function
obesity
oxidative stress
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
17 02 2020
17 02 2020
Historique:
received:
27
01
2020
revised:
10
02
2020
accepted:
13
02
2020
entrez:
22
2
2020
pubmed:
23
2
2020
medline:
10
3
2021
Statut:
epublish
Résumé
The impact of the mitochondria-targeted antioxidant MitoQ was evaluated in the cardiac alterations associated with obesity. Male Wistar rats were fed either a high fat diet (HFD, 35% fat) or a standard diet (CT, 3.5% fat) for 7 weeks and treated with MitoQ (200 µM). The effect of MitoQ (5 nM) in rat cardiac myoblasts treated for 24 h with palmitic acid (PA, 200 µM) was evaluated. MitoQ reduced cardiac oxidative stress and prevented the development of cardiac fibrosis, hypertrophy, myocardial
Identifiants
pubmed: 32079154
pii: cells9020451
doi: 10.3390/cells9020451
pmc: PMC7072852
pii:
doi:
Substances chimiques
Organophosphorus Compounds
0
Ubiquinone
1339-63-5
mitoquinone
47BYS17IY0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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