The Prognostic Value of

Colorectal cancer KRAS mutation 18F-fluoro-deoxy-glucose positron emission tomography/computerized tomography (18F-FDG PET/CT) prognosis

Journal

Molecular imaging and radionuclide therapy
ISSN: 2146-1414
Titre abrégé: Mol Imaging Radionucl Ther
Pays: Turkey
ID NLM: 101584839

Informations de publication

Date de publication:
17 Feb 2020
Historique:
entrez: 22 2 2020
pubmed: 23 2 2020
medline: 23 2 2020
Statut: ppublish

Résumé

Prognostic effect of KRAS mutation and side of tumor in colorectal cancer is a highly controversial subject. Therefore, we evaluated the association between FDG uptake pattern in Eighty-three patients with colorectal cancer were retrospectively included in this study. Twenty five patients were female while 58 were male. The mean age of the patients was 59.8±11.3 years. Mean follow-up was 35.5±18.9 months. Primary tumor was localized in the left colon in 83.1% of patients and in the right colon in 16.9%. KRAS mutation was detected in 54.2% (n=45) of patients. Mean SUV In our study, we found that tumor localization had no significant effect on prognosis in patients with colon cancer. On the other hand, FDG uptake was observed to be higher in the presence of KRAS mutation and it was concluded that coexistence of KRAS mutation with higher SUV Kolorektal kanserde KRAS mutasyonu ve tümörün lokalizasyonu ile ilişkili prognostik etki tartışmalı bir konudur. Bu nedenle Kolorektal kanser tanılı 83 hasta retrospektif olarak bu çalışmaya dahil edildi. Tedavi öncesi evreleme için Olguların 25’i kadın, 58’i erkekti. Hastaların yaş ortalaması 59,8±11,3 idi. Ortalama takip süresi 35,5±18,9 aydı. Primer tümör hastaların %83,1’inde sol kolonda ve %16,9’unda sağ kolonda lokalize idi. KRAS mutasyonu hastaların %54,2’sinde (n=45) tespit edildi. Primer tümörün ortalama SUV Çalışmamızda, kolon tümörü lokalizasyonunun prognoz üzerinde anlamlı bir etkisinin olmadığını bulduk. Öte yandan, FDG tutulumunun KRAS mutasyonu varlığında daha yüksek olduğu gözlendi ve KRAS mutasyonunun yüksek SUV

Autres résumés

Type: Publisher (tur)
Kolorektal kanserde KRAS mutasyonu ve tümörün lokalizasyonu ile ilişkili prognostik etki tartışmalı bir konudur. Bu nedenle

Identifiants

pubmed: 32079384
doi: 10.4274/mirt.galenos.2019.33866
pmc: PMC7057728
doi:

Types de publication

Journal Article

Langues

eng

Pagination

17-24

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Auteurs

Esra Arslan (E)

University of Health and Sciences, İstanbul Training and Research Hospital, Clinic of Nuclear Medicine, İstanbul, Turkey

Tamer Aksoy (T)

University of Health and Sciences, İstanbul Training and Research Hospital, Clinic of Nuclear Medicine, İstanbul, Turkey

Rıza Umar Gürsu (RU)

University of Health and Sciences, İstanbul Training and Research Hospital, Clinic of Medical Oncology, İstanbul, Turkey

Nevra Dursun (N)

University of Health and Sciences, İstanbul Training and Research Hospital, Clinic of Pathology, İstanbul, Turkey

Ekrem Çakar (E)

University of Health and Sciences, İstanbul Training and Research Hospital, Clinic of Surgery, İstanbul, Turkey

Tevfik Fikret Çermik (TF)

University of Health and Sciences, İstanbul Training and Research Hospital, Clinic of Nuclear Medicine, İstanbul, Turkey

Classifications MeSH