Tobacco smoke exposure and socioeconomic factors are independent predictors of pulmonary decline in pediatric cystic fibrosis.
Journal
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
ISSN: 1873-5010
Titre abrégé: J Cyst Fibros
Pays: Netherlands
ID NLM: 101128966
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
29
09
2019
revised:
07
01
2020
accepted:
06
02
2020
pubmed:
23
2
2020
medline:
21
10
2021
entrez:
22
2
2020
Statut:
ppublish
Résumé
Pulmonary decline in CF is heterogeneous, with socio-environmental factors contributing to this variability. Few studies have attempted to disentangle the effects of tobacco smoke exposure and socioeconomic factors on lung function deterioration in pediatric CF. The current study evaluates their contributions longitudinally across the entire U.S. CF care network population. Data from the CF Foundation Patient Registry were obtained on all individuals who at the end of 2016 were 6-18 years old. Lung function measures (ppFEV The sample included 10,895 individuals contributing 65,581 person years. At age 6, ppFEV Smoke exposure and socioeconomic factors are independent risk factors for decreased ppFEV
Sections du résumé
BACKGROUND
Pulmonary decline in CF is heterogeneous, with socio-environmental factors contributing to this variability. Few studies have attempted to disentangle the effects of tobacco smoke exposure and socioeconomic factors on lung function deterioration in pediatric CF. The current study evaluates their contributions longitudinally across the entire U.S. CF care network population.
METHODS
Data from the CF Foundation Patient Registry were obtained on all individuals who at the end of 2016 were 6-18 years old. Lung function measures (ppFEV
RESULTS
The sample included 10,895 individuals contributing 65,581 person years. At age 6, ppFEV
CONCLUSIONS
Smoke exposure and socioeconomic factors are independent risk factors for decreased ppFEV
Identifiants
pubmed: 32081643
pii: S1569-1993(20)30049-7
doi: 10.1016/j.jcf.2020.02.004
pmc: PMC7429279
mid: NIHMS1562977
pii:
doi:
Substances chimiques
Tobacco Smoke Pollution
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
783-790Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK072482
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL140108
Pays : United States
Organisme : AHRQ HHS
ID : K12 HS023009
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL135816
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL140190
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors have no conflicts of interest.
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