Toward personalization of asthma treatment according to trigger factors.

Allergens / immunology Animals Asthma / immunology Biomarkers / metabolism Humans Precision Medicine / methods Rhinovirus / immunology
Asthma allergen allergy microarray rhinovirus wheeze

Journal

The Journal of allergy and clinical immunology
ISSN: 1097-6825
Titre abrégé: J Allergy Clin Immunol
Pays: United States
ID NLM: 1275002

Informations de publication

Date de publication:
06 2020
Historique:
received: 17 12 2019
revised: 06 02 2020
accepted: 07 02 2020
pubmed: 23 2 2020
medline: 20 2 2021
entrez: 22 2 2020
Statut: ppublish

Résumé

Asthma is a severe and chronic disabling disease affecting more than 300 million people worldwide. Although in the past few drugs for the treatment of asthma were available, new treatment options are currently emerging, which appear to be highly effective in certain subgroups of patients. Accordingly, there is a need for biomarkers that allow selection of patients for refined and personalized treatment strategies. Recently, serological chip tests based on microarrayed allergen molecules and peptides derived from the most common rhinovirus strains have been developed, which may discriminate 2 of the most common forms of asthma, that is, allergen- and virus-triggered asthma. In this perspective, we argue that classification of patients with asthma according to these common trigger factors may open new possibilities for personalized management of asthma.

Identifiants

DOI: 10.1016/j.jaci.2020.02.001 PMID: 32081759 PMC: PMC7613502
pubmed: 32081759
pii: S0091-6749(20)30193-7
doi: 10.1016/j.jaci.2020.02.001
pmc: PMC7613502
mid: EMS153503
pii:
doi:

Substances chimiques

Allergens 0
Biomarkers 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1529-1534

Subventions

Organisme : Wellcome Trust
ID : 203077
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K002449/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S025340/1
Pays : United Kingdom
Organisme : Austrian Science Fund FWF
ID : P 29398
Pays : Austria

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

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Auteurs

Katarzyna Niespodziana (K)

Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

Kristina Borochova (K)

Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

Petra Pazderova (P)

Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

Thomas Schlederer (T)

Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

Natalia Astafyeva (N)

Department of Clinical Immunology and Allergology of Saratov State Medical University, Saratov, Russia.

Tatiana Baranovskaya (T)

Belarusian Medical Academy of Post Diploma Studies, Minsk, Belarus.

Mohamed-Ridha Barbouche (MR)

Department of Immunology, Institut Pasteur de Tunis, Tunis, Tunisia.

Evgeny Beltyukov (E)

Department of Faculty Therapy, Endocrinology, Allergology and Immunology, Ural State Medical University, Ekaterinburg, Russia.

Angelika Berger (A)

Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.

Elena Borzova (E)

Department of Clinical Allergology and Immunology, Russian Medical Academy of Continuous Professional Education, Moscow, Russia; Department of Clinical Genetics, Research and Clinical Institute for Pediatrics named after Yuri Veltischev at the Pirogov Russian National Research Medical University, Moscow, Russia; Department of Dermatology and Venereology, I.V. Sechenov First State Medical University, Moscow, Russia.

Jean Bousquet (J)

University Hospital, Montpellier, France; MACVIA-France, Montpellier, France; Charité, Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Comprehensive Allergy Center, Department of Dermatology and Allergy, Berlin, Germany.

Roxana S Bumbacea (RS)

Department of Allergology and Clinical Immunology, University of Medicine and Pharmacy "Carol Davila," Bucharest, Romania.

Snezhana Bychkovskaya (S)

Department of Pediatrics, Krasnoyarsk Medical University, Kransnoyarsk, Russia.

Luis Caraballo (L)

Institute for Immunological Research, The University of Cartagena, Cartagena de Indias, Colombia.

Kian Fan Chung (KF)

National Heart & Lung Institute, Imperial College London, London, United Kingdom; MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom.

Adnan Custovic (A)

National Heart & Lung Institute, Imperial College London, London, United Kingdom; MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom.

Guillermo Docena (G)

Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.

Thomas Eiwegger (T)

Translational Medicine Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada; Department of Immunology, University of Toronto, Toronto, Ontario, Canada; Division of Immunology and Allergy, Food Allergy and Anaphylaxis Program, Hospital for Sick Children, Departments of Paedriatrics and Immunology, University of Toronto, Toronto, Ontario, Canada.

Irina Evsegneeva (I)

Laboratory of Immunopathology, Department of Clinical Immunology and Allergy, Sechenov First Moscow State Medical University, Moscow, Russia.

Alexander Emelyanov (A)

Department of Respiratory Medicine and Allergy, North-Western Medical University, St Petersburg, Russia.

Peter Errhalt (P)

Department of Pneumology, University Hospital Krems and Karl Landsteiner University of Health Sciences, Krems, Austria.

Rustem Fassakhov (R)

Institute of Fundamental Medicine and Biology of Kazan Federal University, Kazan, Russia.

Rezeda Fayzullina (R)

Faculty of Pediatrics, Bashkir State Medical University, Ufa, Russia.

Elena Fedenko (E)

NRC Institute of Immunology FMBA of Russia, Moscow, Russia.

Daria Fomina (D)

Laboratory of Immunopathology, Department of Clinical Immunology and Allergy, Sechenov First Moscow State Medical University, Moscow, Russia; City Moscow Center of Allergy and Immunology, Clinical Hospital No. 52, Moscow, Russia.

Zhongshan Gao (Z)

Allergy Research Center, Zhejiang University, Hangzhou, China.

Pedro Giavina-Bianchi (P)

Clinical Immunology and Allergy Division, University of Sao Paulo, Sao Paulo, Brazil.

Maia Gotua (M)

Center of Allergy and Immunology, David Tvildiani Medical University, Tbilisi, Georgia.

Susanne Greber-Platzer (S)

Division of Pediatric Pulmonology, Allergology and Endocrinology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center Pediatrics, Medical University of Vienna, Vienna, Austria.

Gunilla Hedlin (G)

Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden; Department of Womenś and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Natalia Ilina (N)

NRC Institute of Immunology FMBA of Russia, Moscow, Russia.

Zhanat Ispayeva (Z)

Allergology Department, Kazakh National Medical University, Almaty, Kazakhstan.

Marco Idzko (M)

Department of Pneumology, Medical University of Vienna, Vienna, Austria.

Sebastian L Johnston (SL)

National Heart & Lung Institute, Imperial College London, London, United Kingdom; MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, London, United Kingdom.

Ömer Kalayci (Ö)

Pediatric Allergy and Asthma Unit, Hacettepe University School of Medicine, Ankara, Turkey.

Alexander Karaulov (A)

Laboratory of Immunopathology, Department of Clinical Immunology and Allergy, Sechenov First Moscow State Medical University, Moscow, Russia.

Antonina Karsonova (A)

Laboratory of Immunopathology, Department of Clinical Immunology and Allergy, Sechenov First Moscow State Medical University, Moscow, Russia.

Musa Khaitov (M)

NRC Institute of Immunology FMBA of Russia, Moscow, Russia.

Elena Kovzel (E)

Department of Clinical Immunology, Allergology, Pulmonology, Republic Diagnostic Center, Corporate Fund University Medical Center of Nazarbayev University, Nur-Sultan, Kazakhstan.

Marek L Kowalski (ML)

Department of Allergy and Immunology, Medical University Lodz, Lodz, Poland.

Dmitry Kudlay (D)

NRC Institute of Immunology FMBA of Russia, Moscow, Russia.

Michael Levin (M)

Division of Asthma and Allergy, University of Cape Town, Cape Town, South Africa.

Svetlana Makarova (S)

Department of Preventive Pediatrics, National Medical Research Center for Children's Health, Moscow, Russia.

Paolo Maria Matricardi (PM)

Department of Pediatric Pulmonology, Immunology and Intensive Care Medicine, Charité-University Medicine Berlin, Berlin, Germany.

Kari C Nadeau (KC)

Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, Calif.

Leyla Namazova-Baranova (L)

Department of Pediatrics, Russian National Research Medical University of MoH RF, Moscow, Russia.

Olga Naumova (O)

Center of Allergic Diseases of Upper Respiratory Ways, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine.

Oleksandr Nazarenko (O)

Department of Clinical and Laboratory Allergology and Immunology, National Medical Academy of Postgraduate Education, Kyiv, Ukraine.

Paul M O'Byrne (PM)

Firestone Institute of Respiratory Health, Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Canada.

Faith Osier (F)

KEMRI-Wellcome Trust Research Programme (KWTRP), Kilifi, Kenya.

Alexander N Pampura (AN)

Department of Allergology and Clinical Immunology, Research and Clinical Institute for Pediatrics named after Yuri Veltischev at the Pirogov Russian National Research Medical University of the Russian Ministry of Health, Moscow, Russia.

Carmen Panaitescu (C)

OncoGen Center, County Clinical Emergency Hospital "Pius Branzeu," and University of Medicine and Pharmacy V Babes, Timisoara, Romania.

Nikolaos G Papadopoulos (NG)

Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, United Kingdom; Allergy Department, 2nd Pediatric Clinic, National Kapodistrian University of Athens, Athens, Greece.

Hae-Sim Park (HS)

Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.

Ruby Pawankar (R)

Department of Pediatrics, Nippon Medical School, Tokyo, Japan.

Wolfgang Pohl (W)

Pulmonary Department and Karl Landsteiner Institute for Clinical and Experimental Pulmology, Hietzing Hospital, Vienna, Austria.

Harald Renz (H)

Institute of Laboratory Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Philipps University Marburg, German Center for Lung Research (DZL) Marburg, Marburg, Germany.

Ksenja Riabova (K)

Laboratory of Immunopathology, Department of Clinical Immunology and Allergy, Sechenov First Moscow State Medical University, Moscow, Russia.

Vanitha Sampath (V)

Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, Calif.

Bülent E Sekerel (BE)

Pediatric Allergy and Asthma Unit, Hacettepe University School of Medicine, Ankara, Turkey.

Elopy Sibanda (E)

Asthma, Allergy and Immune Dysfunction Clinic, Twin Palms Medical Centre, Harare, Zimbabwe; Department of Pathology, Medical School, National University of Science and Technology, Bulawayo, Zimbabwe.

Valérie Siroux (V)

Univ. Grenoble Alpes, Inserm, CNRS, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, IAB, Grenoble, France.

Ludmila P Sizyakina (LP)

Department of Allergology and Immunology, Rostov Medical University, Rostov, Russia.

Jin-Lyu Sun (JL)

Department of Allergy and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Zsolt Szepfalusi (Z)

Division of Pediatric Pulmonology, Allergology and Endocrinology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center Pediatrics, Medical University of Vienna, Vienna, Austria.

Tetiana Umanets (T)

Department of Respiratory Diseases and Respiratory Allergy in Children, Institute of Pediatrics, Obstetrics and Gynecology, National Academy of Medical Sciences, Kyiv, Ukraine.

Hugo P S Van Bever (HPS)

Department of Paediatrics, National University of Singapore, Singapore, Singapore.

Marianne van Hage (M)

Division of Immunology and Allergy, Department of Medicine, Karolinska Institutet and University Hospital, Stockholm.

Margarita Vasileva (M)

Center of Allergology and Clinical Immunology, Regional Clinical Hospital, Khabarovsk, Russia.

Erika von Mutius (E)

Dr. von Hauner Children's Hospital, Ludwig Maximilian University Munich, Munich, Germany; Institute of Asthma and Allergy Prevention, Helmholtz Centre Munich, Munich, Germany; German Centre for Lung Research, Germany.

Jiu-Yao Wang (JY)

Center for Allergy and Clinical Immunology Research (ACIR), Department of Pediatrics, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.

Gary W K Wong (GWK)

Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

Sergii Zaikov (S)

Department of Phtihisiatry and Pulmonology, Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine.

Mihaela Zidarn (M)

University Clinic of Pulmonary and Allergic Diseases Golnik, Golnik, Slovenia; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Rudolf Valenta (R)

Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria; Laboratory of Immunopathology, Department of Clinical Immunology and Allergy, Sechenov First Moscow State Medical University, Moscow, Russia; NRC Institute of Immunology FMBA of Russia, Moscow, Russia; Division of Immunology and Allergy, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden; Karl Landsteiner University, Krems, Austria. Electronic address: rudolf.valenta@meduniwien.ac.at.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Antigènes › Allergènes › Toward personalization of asthma treatment...
questionsmedicales.fr › Eucaryotes › Animaux › Toward personalization of asthma treatment...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité respiratoire › Asthme › Toward personalization of asthma treatment...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Toward personalization of asthma treatment...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Toward personalization of asthma treatment...
questionsmedicales.fr › Professions de santé › Médecine › Médecine clinique › Médecine de précision › Toward personalization of asthma treatment...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Picornaviridae › Rhinovirus › Toward personalization of asthma treatment...