Discovery and development of safe-in-man broad-spectrum antiviral agents.
Antiviral drug
BSAAs
Broad-spectrum antiviral agents
Drug discovery and development
Virus
Journal
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
ISSN: 1878-3511
Titre abrégé: Int J Infect Dis
Pays: Canada
ID NLM: 9610933
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
24
01
2020
revised:
07
02
2020
accepted:
11
02
2020
pubmed:
23
2
2020
medline:
25
7
2020
entrez:
22
2
2020
Statut:
ppublish
Résumé
Viral diseases are one of the leading causes of morbidity and mortality in the world. Virus-specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases. However, broad-spectrum antiviral agents (BSAAs, i.e. compounds targeting viruses belonging to two or more viral families) could provide additional protection of the general population from emerging and re-emerging viral diseases, reinforcing the arsenal of available antiviral options. Here, we review discovery and development of BSAAs and summarize the information on 120 safe-in-man agents in a freely accessible database (https://drugvirus.info/). Future and ongoing pre-clinical and clinical studies will increase the number of BSAAs, expand the spectrum of their indications, and identify drug combinations for treatment of emerging and re-emerging viral infections as well as co-infections.
Identifiants
pubmed: 32081774
pii: S1201-9712(20)30076-X
doi: 10.1016/j.ijid.2020.02.018
pmc: PMC7128205
pii:
doi:
Substances chimiques
Antiviral Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
268-276Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
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