Sex-dependent effects of chronic variable stress on discrete corticotropin-releasing factor receptor 1 cell populations.
Anxiety
Chronic stress
Corticotropin releasing factor
Sex difference
Journal
Physiology & behavior
ISSN: 1873-507X
Titre abrégé: Physiol Behav
Pays: United States
ID NLM: 0151504
Informations de publication
Date de publication:
15 05 2020
15 05 2020
Historique:
received:
15
11
2019
revised:
25
01
2020
accepted:
13
02
2020
pubmed:
23
2
2020
medline:
22
6
2021
entrez:
22
2
2020
Statut:
ppublish
Résumé
Anxiety and depression are strikingly more prevalent in women compared with men. Dysregulation of corticotropin-releasing factor (CRF) binding to its cognate receptor (CRFR1) is thought to play a critical role in the etiology of these disorders. In the present study, we investigated whether there were sex differences in the effects of chronic variable stress (CVS) on CRFR1 cells using CRFR1-GFP reporter mice experiencing a 9-day CVS paradigm. Brains were collected from CVS and stress naïve female and male mice following exposure to the open field test. This CVS paradigm effectively increased anxiety-like behavior in female and male mice. In addition, we assessed changes in activation of CRFR1 cells (co-localization with c-Fos and phosphorylated CREB (pCREB)) in stress associated brain structures, including two sexually dimorphic CRFR1 cell groups in the anteroventral periventricular nucleus (AVPV/PeN; F>M) and paraventricular hypothalamus (PVN; M>F). CVS increased CRFR1-GFP cell number as well as the number of CRFR1/pCREB co-expressing cells in the female but not male AVPV/PeN. In the PVN, the number of CRFR1/pCREB co-expressing cells was overall greater in males regardless of treatment and CVS resulted in a male-specific reduction of CRFR1/c-Fos cells. In addition, CVS induced a female-specific reduction in CRFR1/c-Fos cells within the anteroventral bed nucleus of the stria terminalis and both sexes exhibited a reduction in CRFR1/c-Fos co-expressing cells following CVS within the ventral basolateral amygdala. Overall, these sex-specific effects of CVS on CRFR1 populations may have implications for sex differences in stress-induction of mood disorders.
Identifiants
pubmed: 32081812
pii: S0031-9384(20)30164-5
doi: 10.1016/j.physbeh.2020.112847
pmc: PMC7540729
mid: NIHMS1568163
pii:
doi:
Substances chimiques
Receptors, Corticotropin-Releasing Hormone
0
CRF receptor type 1
5CLY6W2H1M
Corticotropin-Releasing Hormone
9015-71-8
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
112847Subventions
Organisme : NICHD NIH HHS
ID : R01 HD097331
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC017149
Pays : United States
Organisme : NIMH NIH HHS
ID : R15 MH118692
Pays : United States
Organisme : NICHD NIH HHS
ID : R15 HD096411
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH112768
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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