The effects of NMDA receptor blockade on TMS-evoked EEG potentials from prefrontal and parietal cortex.
Adult
Bayes Theorem
Cross-Over Studies
Dextromethorphan
/ pharmacology
Double-Blind Method
Electroencephalography
Evoked Potentials
Humans
Magnetic Resonance Imaging
Male
Neurosciences
Parietal Lobe
/ diagnostic imaging
Prefrontal Cortex
/ diagnostic imaging
Receptors, N-Methyl-D-Aspartate
/ antagonists & inhibitors
Transcranial Magnetic Stimulation
Young Adult
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 02 2020
21 02 2020
Historique:
received:
02
08
2019
accepted:
21
01
2020
entrez:
22
2
2020
pubmed:
23
2
2020
medline:
31
12
2020
Statut:
epublish
Résumé
Measuring the brain's response to transcranial magnetic stimulation (TMS) with electroencephalography (EEG) offers unique insights into the cortical circuits activated following stimulation, particularly in non-motor regions where less is known about TMS physiology. However, the mechanisms underlying TMS-evoked EEG potentials (TEPs) remain largely unknown. We assessed TEP sensitivity to changes in excitatory neurotransmission mediated by n-methyl-d-aspartate (NMDA) receptors following stimulation of non-motor regions. In fourteen male volunteers, resting EEG and TEPs from prefrontal (PFC) and parietal (PAR) cortex were measured before and after administration of either dextromethorphan (NMDA receptor antagonist) or placebo across two sessions in a double-blinded pseudo-randomised crossover design. At baseline, there were amplitude differences between PFC and PAR TEPs across a wide time range (15-250 ms), however the signals were correlated after ~80 ms, suggesting early peaks reflect site-specific activity, whereas late peaks reflect activity patterns less dependent on the stimulated sites. Early TEP peaks were not reliably altered following dextromethorphan compared to placebo, although findings were less clear for later peaks, and low frequency resting oscillations were reduced in power. Our findings suggest that early TEP peaks (<80 ms) from PFC and PAR reflect stimulation site specific activity that is largely insensitive to changes in NMDA receptor-mediated neurotransmission.
Identifiants
pubmed: 32081901
doi: 10.1038/s41598-020-59911-6
pii: 10.1038/s41598-020-59911-6
pmc: PMC7035341
doi:
Substances chimiques
Receptors, N-Methyl-D-Aspartate
0
Dextromethorphan
7355X3ROTS
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3168Références
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