Renal accumulation of prooxidant mineral elements and CKD in domestic cats.
Animal Feed
Animals
Antioxidants
Arsenic
Arsenicals
/ chemistry
Cat Diseases
/ prevention & control
Cats
Dogs
Female
Fibrosis
/ urine
Fishes
Food Contamination
Kidney
/ drug effects
Male
Mass Spectrometry
Nephritis, Interstitial
/ urine
Oxidants
/ metabolism
Oxidation-Reduction
Reactive Oxygen Species
Renal Insufficiency, Chronic
/ metabolism
Trace Elements
/ analysis
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 02 2020
21 02 2020
Historique:
received:
19
09
2019
accepted:
17
01
2020
entrez:
22
2
2020
pubmed:
23
2
2020
medline:
31
12
2020
Statut:
epublish
Résumé
Felids have a high incidence of chronic kidney disease (CKD), for which the most common renal lesion is chronic interstitial nephritis (CIN). CIN can be induced by tissue oxidative stress, which is determined by the cellular balance of pro- and anti-oxidant metabolites. Fish-flavoured foods are more often fed to cats than dogs, and such foods tend to have higher arsenic content. Arsenic is a pro-oxidant metallic element. We propose that renal accumulation of pro-oxidant elements such as arsenic and depletion of anti-oxidant elements such as zinc, underpin the high incidence of CIN in domestic cats. Total arsenic and other redox-reactive metal elements were measured in kidneys (after acid-digestion) and urine (both by inductively-coupled plasma-mass spectrometry) of domestic cats (kidneys, n = 56; urine, n = 21), domestic dogs (kidneys, n = 54; urine, n = 28) and non-domesticated Scottish Wildcats (kidneys, n = 17). Renal lesions were graded by severity of CIN. In our randomly sampled population, CIN was more prevalent in domestic cat versus domestic dog (51%, n = 32 of 62 cats; 15%, 11 of 70 dogs were positive for CIN, respectively). CIN was absent from all Scottish wildcats. Tissue and urinary (corrected for creatinine) arsenic content was higher in domestic cats, relative to domestic dogs and wildcats. Urine arsenic was higher in domestic cats and dogs with CIN. Arsenobetaine, an organic and relatively harmless species of arsenic, was the primary form of arsenic found in pet foods. In summary, the kidneys of domestic cats appear to have greater levels of pro-oxidant trace elements, as compared to dogs and wildcats. Since there was no difference in renal arsenic levels in cats with or without CIN, renal arsenic accumulation does not appear a primary driver of excess CIN in cats. Given clear differences in renal handling of pro vs. anti-oxidant minerals between cats and dogs, further in vivo balance studies are warranted. These may then inform species-specific guidelines for trace element incorporation into commercial diets.
Identifiants
pubmed: 32081923
doi: 10.1038/s41598-020-59876-6
pii: 10.1038/s41598-020-59876-6
pmc: PMC7035273
doi:
Substances chimiques
Antioxidants
0
Arsenicals
0
Oxidants
0
Reactive Oxygen Species
0
Trace Elements
0
Arsenic
N712M78A8G
arsenobetaine
UWC1LS4V3I
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3160Références
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