Self-organizing pattern of subpleural alveolar ducts.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 02 2020
21 02 2020
Historique:
received:
07
11
2019
accepted:
03
02
2020
entrez:
22
2
2020
pubmed:
23
2
2020
medline:
13
11
2020
Statut:
epublish
Résumé
In this study we have utilized an optical clearing method to allow visualization of a heretofore undescribed subpleural acinar structural organization in the mammalian lung. The clearing method enables visualization of the lung structure deep below the visceral pleura in intact inflated lungs. In addition to confirming previous observations that the immediate subpleural alveoli are uniform in appearance, we document for the first time that the subpleural lung parenchyma is much more uniformly organized than the internal parenchyma. Specifically, we report that below the surface layer of alveoli, there is a striking parallel arrangement of alveolar ducts that all run perpendicular to the visceral pleural surface. A three dimensional visualization of alveolar ducts allowed for a calculation of the average inner to outer duct diameter ratio of 0.53 in these subpleural ducts. This unique, self-organizing parallel duct structure likely impacts both elastic recoil and the transmission of tethering forces in healthy and diseased lungs.
Identifiants
pubmed: 32081933
doi: 10.1038/s41598-020-59752-3
pii: 10.1038/s41598-020-59752-3
pmc: PMC7035422
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
3185Subventions
Organisme : NIAID NIH HHS
ID : T32 AI007417
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL140623
Pays : United States
Organisme : ODCDC CDC HHS
ID : S10 OD023548
Pays : United States
Organisme : NIH HHS
ID : S10 OD023548
Pays : United States
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