A Brief Review of the Degenerative Intervertebral Disc Disease.
degenerative disease
fibrous annulus
intervertebral disc
nucleus pulposus
spine
Journal
Medical archives (Sarajevo, Bosnia and Herzegovina)
ISSN: 1986-5961
Titre abrégé: Med Arch
Pays: Bosnia and Herzegovina
ID NLM: 101635337
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
entrez:
22
2
2020
pubmed:
23
2
2020
medline:
2
7
2020
Statut:
ppublish
Résumé
The degenerative processes of the intervertebral disc represent an important cause of morbidity in everyday clinical practice, exerting burden on patients and clinicians treating them. Numerous factors may initiate degenerative processes, which most commonly affect the nucleus pulposus and ultimately influence the biomechanics of the whole spine. This paper provides an overview from the literature about the process, causes and mechanisms of disc degeneration and the associated factors. The scientific literature was reviewed through PubMed, Medline and Science Direct. The articles were chosen in correlation with the study objective and their scientific relevance. Many mechanical factors, such as mechanical, traumatic, genetic and nutritional, may affect the integrity of the intervertebral disc. The degenerative processes involve the structural damage of the intervertebral disc and the changes in number and composition of cells. The main factor in the degeneration of the intervertebral disc is the loss of proteoglycans. Degenerative changes of the disc are connected to damage of adjacent structures, leading to functional changes, higher susceptibility to injuries and clinical signs and symptoms. Degenerative disease of the intervertebral disc remains a significant health problem. Besides standard conservative and surgical treatment, techniques of regenerative therapy are becoming very promising, although still in the experimental phase.
Identifiants
pubmed: 32082013
doi: 10.5455/medarh.2019.73.421-424
pmc: PMC7007629
doi:
Substances chimiques
Proteoglycans
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
421-424Informations de copyright
© 2019 Natasa Kos, Lidija Gradisnik, Tomaz Velnar.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
Surg Radiol Anat. 2000;22(1):13-9
pubmed: 10863741
Biomol Concepts. 2018 May 19;9(1):43-52
pubmed: 29779014
Pain Physician. 2009 May-Jun;12(3):561-72
pubmed: 19461823
Rofo. 2018 Feb;190(2):144-151
pubmed: 28863414
Spine (Phila Pa 1976). 2004 Dec 1;29(23):2691-9
pubmed: 15564918
J Bone Joint Surg Am. 2006 Apr;88 Suppl 2:30-5
pubmed: 16595440
Curr Mol Biol Rep. 2018 Dec;4(4):180-190
pubmed: 30473991
Medicine (Baltimore). 2016 May;95(22):e3495
pubmed: 27258491
Spine J. 2010 Mar;10(3):200-8
pubmed: 20006557
Spine (Phila Pa 1976). 2004 Dec 1;29(23):2700-9
pubmed: 15564919
J Neurosurg Spine. 2009 Oct;11(4):501-7
pubmed: 19929349
Spine (Phila Pa 1976). 2008 Dec 1;33(25):2801-8
pubmed: 19050586
Int J Obes (Lond). 2005 Aug;29(8):903-8
pubmed: 15917859
J Chin Med Assoc. 2009 Dec;72(12):650-3
pubmed: 20028647
Int J Biochem Cell Biol. 2008;40(5):837-42
pubmed: 18243770
J Orthop Res. 2016 Aug;34(8):1289-306
pubmed: 26890203
Eur Spine J. 2002 Oct;11 Suppl 2:S215-20
pubmed: 12384747
Appl Health Econ Health Policy. 2019 Aug;17(4):467-491
pubmed: 30941658
Spine (Phila Pa 1976). 2009 Oct 1;34(21):2288-96
pubmed: 19934808
Spine (Phila Pa 1976). 2009 Apr 20;34(9):934-40
pubmed: 19532001
World Neurosurg. 2019 Jan;121:e426-e432
pubmed: 30267950
Int J Biol Sci. 2008 Sep 02;4(5):283-90
pubmed: 18781226
J Biomech. 2010 Jan 5;43(1):137-45
pubmed: 19828150
Spine (Phila Pa 1976). 2009 Jan 1;34(1):10-6
pubmed: 19127156
Eur Spine J. 2017 Jan;26(1):248-258
pubmed: 27084189
J Bone Joint Surg Am. 2006 Apr;88 Suppl 2:52-7
pubmed: 16595444
Conf Proc IEEE Eng Med Biol Soc. 2007;2007:6401-6
pubmed: 18003487
Spine (Phila Pa 1976). 1988 Feb;13(2):173-8
pubmed: 3406837
Curr Mol Biol Rep. 2018 Dec;4(4):151-160
pubmed: 30546999
Neurosurgery. 2009 Feb;64(2):338-44; discussion 344-5
pubmed: 19190461
J Biomech. 2009 Aug 25;42(12):1941-6
pubmed: 19539936
Joint Bone Spine. 2008 Jul;75(4):383-7
pubmed: 18448379
Eur Spine J. 2014 Sep;23(9):1856-62
pubmed: 24828957
Int Arch Occup Environ Health. 2016 Nov;89(8):1321-1328
pubmed: 27613561