Structural Variants May Be a Source of Missing Heritability in sALS.
amyotrophic lateral sclerosis
clinical trial stratification
genetic marker
missing heritability
structural variant
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2020
2020
Historique:
received:
21
10
2019
accepted:
13
01
2020
entrez:
22
2
2020
pubmed:
23
2
2020
medline:
23
2
2020
Statut:
epublish
Résumé
The underlying genetic and molecular mechanisms that drive amyotrophic lateral sclerosis (ALS) remain poorly understood. Structural variants within the genome can play a significant role in neurodegenerative disease risk, such as the repeat expansion in
Identifiants
pubmed: 32082115
doi: 10.3389/fnins.2020.00047
pmc: PMC7005198
doi:
Types de publication
Journal Article
Langues
eng
Pagination
47Informations de copyright
Copyright © 2020 Theunissen, Flynn, Anderton, Mastaglia, Pytte, Jiang, Hodgetts, Burns, Saunders, Fletcher, Wilton and Akkari.
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