Blinded
Torsades de Pointes
drug cardiotoxicity
human ventricular action potential
in silico drug trials
ion channels
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2019
2019
Historique:
received:
25
07
2019
accepted:
16
12
2019
entrez:
22
2
2020
pubmed:
23
2
2020
medline:
23
2
2020
Statut:
epublish
Résumé
Torsades de Pointes (TdP) is a type of ventricular arrhythmia which could be observed as an unwanted drug-induced cardiac side effect, and it is associated with repolarization abnormalities in single cells. The pharmacological evaluations of TdP risk in previous years mainly focused on the hERG channel due to its vital role in the repolarization of cardiomyocytes. However, only considering drug effects on hERG led to false positive predictions since the drug action on other ion channels can also have crucial regulatory effects on repolarization. To address the limitation of only evaluating hERG, the Comprehensive in Vitro Proarrhythmia Assay initiative has proposed to systematically integrate drug effects on multiple ion channels into
Identifiants
pubmed: 32082155
doi: 10.3389/fphar.2019.01643
pmc: PMC7003137
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1643Subventions
Organisme : British Heart Foundation
ID : FS/17/22/32644
Pays : United Kingdom
Informations de copyright
Copyright © 2020 Zhou, Qu, Passini, Bueno-Orovio, Liu, Vargas and Rodriguez.
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