A very low thymus function identifies patients with substantial increased risk for long-term mortality after kidney transplantation.
Kidney transplantation
Mortality
Premature ageing
Thymus
naïve T cells;recent thymic emigrants
Journal
Immunity & ageing : I & A
ISSN: 1742-4933
Titre abrégé: Immun Ageing
Pays: England
ID NLM: 101235427
Informations de publication
Date de publication:
2020
2020
Historique:
received:
25
10
2019
accepted:
02
02
2020
entrez:
22
2
2020
pubmed:
23
2
2020
medline:
23
2
2020
Statut:
epublish
Résumé
End-stage renal disease is associated with premature ageing of the T cell immune system but inter-individual variation is substantial. The hypothesis was tested that advanced immunological T cell ageing assessed by peripheral T cell differentiation increases the long-term mortality risk after renal transplantation. Circulating T cells of 211 recipients of a kidney from a living donor were analyzed before and in the first year after transplantation. The number of CD31-positive naive T cells (as a marker for recent thymic emigrants) and the differentiation status of the memory T cells was assessed. Thirty recipients died during follow-up of at least 5 years. Absolute numbers of naive CD4 A severe reduction in circulating naïve T cells because of a decrease in recent thymic emigrants is highly associated with all-cause mortality after renal transplantation.
Sections du résumé
BACKGROUND
BACKGROUND
End-stage renal disease is associated with premature ageing of the T cell immune system but inter-individual variation is substantial. The hypothesis was tested that advanced immunological T cell ageing assessed by peripheral T cell differentiation increases the long-term mortality risk after renal transplantation.
RESULTS
RESULTS
Circulating T cells of 211 recipients of a kidney from a living donor were analyzed before and in the first year after transplantation. The number of CD31-positive naive T cells (as a marker for recent thymic emigrants) and the differentiation status of the memory T cells was assessed. Thirty recipients died during follow-up of at least 5 years. Absolute numbers of naive CD4
CONCLUSIONS
CONCLUSIONS
A severe reduction in circulating naïve T cells because of a decrease in recent thymic emigrants is highly associated with all-cause mortality after renal transplantation.
Identifiants
pubmed: 32082402
doi: 10.1186/s12979-020-00175-z
pii: 175
pmc: PMC7020578
doi:
Types de publication
Journal Article
Langues
eng
Pagination
4Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare that they have no competing interests.
Références
Am J Kidney Dis. 1995 Sep;26(3):454-60
pubmed: 7645553
Exp Gerontol. 2002 Jan-Mar;37(2-3):445-53
pubmed: 11772532
Am J Transplant. 2016 Aug;16(8):2324-33
pubmed: 26914971
J Exp Med. 2002 Mar 18;195(6):789-94
pubmed: 11901204
Immun Ageing. 2011 Jan 08;8(1):2
pubmed: 21214947
Immunity. 2012 Feb 24;36(2):288-97
pubmed: 22365666
J Am Geriatr Soc. 2017 Jan;65(1):153-159
pubmed: 27775813
J Am Soc Nephrol. 2010 May;21(5):868-75
pubmed: 20203160
Nat Rev Immunol. 2018 Jun;18(6):363-373
pubmed: 29520044
Transplantation. 2013 Nov 27;96(10):904-13
pubmed: 23985721
Immun Ageing. 2015 Dec 14;12:28
pubmed: 26677394
Kidney Int. 2011 Jul;80(2):208-17
pubmed: 21525849
World J Nephrol. 2014 Nov 6;3(4):268-76
pubmed: 25374821
Am J Transplant. 2015 Dec;15(12):3143-56
pubmed: 26211927
Front Immunol. 2017 Dec 15;8:1826
pubmed: 29326709
Nat Med. 2016 Jan;22(1):72-7
pubmed: 26657141
Nature. 1999 Oct 14;401(6754):708-12
pubmed: 10537110
Mech Ageing Dev. 2000 Dec 20;121(1-3):187-201
pubmed: 11164473
Kidney Int. 2006 Jul;70(2):371-6
pubmed: 16738532
Immun Ageing. 2012 Sep 12;9(1):19
pubmed: 22971545
Sci Immunol. 2016 Dec;1(6):
pubmed: 28361127
Blood Purif. 2013;36(3-4):173-8
pubmed: 24496187
J Infect Dis. 2010 Sep 1;202(5):690-9
pubmed: 20632887
Clin Exp Immunol. 2017 May;188(2):299-310
pubmed: 28142201
Nephrol Dial Transplant. 2007 Nov;22(11):3298-303
pubmed: 17597084
Nephrol Dial Transplant. 2010 Nov;25(11):3640-6
pubmed: 20400452
Transpl Int. 2014 Dec;27(12):1272-84
pubmed: 25082296
Transplantation. 2005 Apr 27;79(8):914-9
pubmed: 15849543
Front Immunol. 2017 Oct 27;8:1416
pubmed: 29163492
Gerontology. 2009;55(3):314-21
pubmed: 19190395
Kidney Int. 2000 Oct;58(4):1758-64
pubmed: 11012910
Biogerontology. 2008 Oct;9(5):299-308
pubmed: 18369735
Nephrol Dial Transplant. 2011 Oct;26(10):3391-8
pubmed: 21385859
Am J Kidney Dis. 2001 Dec;38(6):1264-70
pubmed: 11728959
Blood. 2000 May 1;95(9):2860-8
pubmed: 10779432
Blood. 2009 Jan 22;113(4):769-74
pubmed: 18583570
Cytometry B Clin Cytom. 2017 Jul;92(4):249-257
pubmed: 26566232
Mech Ageing Dev. 1998 May 15;102(2-3):187-98
pubmed: 9720651
Clin Immunol. 2006 Jan;118(1):83-91
pubmed: 16257266
Immun Ageing. 2018 Nov 8;15:27
pubmed: 30455721
Kidney Int. 2004 Aug;66(2):614-21
pubmed: 15253714
J Am Soc Nephrol. 2008 Aug;19(8):1483-90
pubmed: 18480314
Age (Dordr). 2013 Feb;35(1):251-9
pubmed: 22095260
Nat Rev Nephrol. 2013 May;9(5):255-65
pubmed: 23507826
Mech Ageing Dev. 2003 Apr;124(4):449-51
pubmed: 12714252
Am J Kidney Dis. 1999 Mar;33(3):483-91
pubmed: 10070912
PLoS One. 2016 Mar 07;11(3):e0150826
pubmed: 26950734