Successful Kidney Transplantation in a Recipient Coinfected with Hepatitis C Genotype 2 and HIV from a Donor Infected with Hepatitis C Genotype 1 in the Direct-Acting Antiviral Era.
Journal
Case reports in hepatology
ISSN: 2090-6587
Titre abrégé: Case Reports Hepatol
Pays: United States
ID NLM: 101622103
Informations de publication
Date de publication:
2020
2020
Historique:
received:
23
09
2019
accepted:
03
01
2020
entrez:
22
2
2020
pubmed:
23
2
2020
medline:
23
2
2020
Statut:
epublish
Résumé
Despite significant advances in transplantation of HIV-infected individuals, little is known about HIV coinfected patients with hepatitis C virus (HCV) genotypes other than genotype 1, especially when receiving HCV-infected organs with a different genotype. We describe the first case of kidney transplantation in a man coinfected with hepatitis C and HIV in our state. To our knowledge, this is also the first report of an HIV/HCV/HBV tri-infected patient with non-1 (2a) HCV genotype who received an HCV-infected kidney graft with the discordant genotype (1a), to which he converted after transplant. Our case study highlights the following: (1) transplant centers need to monitor wait times for an HCV-infected organ and regularly assess the risk of delaying HCV antiviral treatment for HCV-infected transplant candidates in anticipation of the transplant from an HCV-infected donor; (2) closer monitoring of tacrolimus levels during the early phases of anti-HCV protease inhibitor introduction and discontinuation may be indicated; (3) donor genotype transmission can occur; (4) HIV/HCV coinfected transplant candidates require a holistic approach with emphasis on the cardiovascular risk profile and low threshold for cardiac catheterization as part of their pretransplant evaluation.
Identifiants
pubmed: 32082657
doi: 10.1155/2020/7679147
pmc: PMC7011348
doi:
Types de publication
Case Reports
Langues
eng
Pagination
7679147Informations de copyright
Copyright © 2020 Dimitrios Farmakiotis et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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