Acyldepsipeptide Antibiotics and a Bioactive Fragment Thereof Differentially Perturb

Humans Adenosine Triphosphate / metabolism Anti-Bacterial Agents / pharmacology Bacterial Proteins / metabolism Endopeptidase Clp / chemistry Molecular Chaperones / metabolism Mycobacterium tuberculosis / drug effects Peptide Hydrolases / drug effects Tuberculosis / drug therapy

Journal

ACS chemical biology
ISSN: 1554-8937
Titre abrégé: ACS Chem Biol
Pays: United States
ID NLM: 101282906

Informations de publication

Date de publication:
21 04 2023
Historique:
medline: 24 4 2023
pubmed: 23 2 2020
entrez: 22 2 2020
Statut: ppublish

Résumé

Proteolytic complexes in

Identifiants

DOI: 10.1021/acschembio.9b00454 PMID: 32083462 PMC: PMC7842861
pubmed: 32083462
doi: 10.1021/acschembio.9b00454
pmc: PMC7842861
mid: NIHMS1652936
doi:

Substances chimiques

acyldepsipeptides 0
Adenosine Triphosphate 8L70Q75FXE
Anti-Bacterial Agents 0
Bacterial Proteins 0
Endopeptidase Clp EC 3.4.21.92
Molecular Chaperones 0
Peptide Hydrolases EC 3.4.-
clpP2 protein, Mycobacterium tuberculosis 0
clpP1 protein, Mycobacterium tuberculosis 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

724-733

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI123400
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM101988
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM141517
Pays : United States

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Auteurs

Karl R Schmitz (KR)

Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Department of Biological Sciences, University of Delaware, Newark, Delaware 19716, United States.

Emma L Handy (EL)

Department of Chemistry, Brown University, Providence, Rhode Island 02912, United States.

Corey L Compton (CL)

Department of Chemistry, Brown University, Providence, Rhode Island 02912, United States.

Shashank Gupta (S)

Department of Chemistry, Brown University, Providence, Rhode Island 02912, United States.
Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, United States.

William R Bishai (WR)

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, United States.

Robert T Sauer (RT)

Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

Jason K Sello (JK)

Department of Chemistry, Brown University, Providence, Rhode Island 02912, United States.
Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California 94158-2517, United States.
ORCID: 0000-0001-6263-7902

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Acyldepsipeptide Antibiotics and a Bioactive...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › Acyldepsipeptide Antibiotics and a Bioactive...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Acyldepsipeptide Antibiotics and a Bioactive...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Acyldepsipeptide Antibiotics and a Bioactive...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines végétales › Protéines chloroplastiques › Endopeptidase Clp › Acyldepsipeptide Antibiotics and a Bioactive...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Chaperons moléculaires › Acyldepsipeptide Antibiotics and a Bioactive...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › Acyldepsipeptide Antibiotics and a Bioactive...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Acyldepsipeptide Antibiotics and a Bioactive...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à Actinomycetales › Infections à Mycobacterium › Tuberculose › Acyldepsipeptide Antibiotics and a Bioactive...