Association of Dual Decline in Memory and Gait Speed With Risk for Dementia Among Adults Older Than 60 Years: A Multicohort Individual-Level Meta-analysis.
Journal
JAMA network open
ISSN: 2574-3805
Titre abrégé: JAMA Netw Open
Pays: United States
ID NLM: 101729235
Informations de publication
Date de publication:
05 02 2020
05 02 2020
Historique:
entrez:
22
2
2020
pubmed:
23
2
2020
medline:
25
8
2020
Statut:
epublish
Résumé
Dual decline in both memory and gait speed may characterize a group of older individuals at high risk for future dementia. To assess the risk of dementia in older persons who experience parallel declines in memory and gait speed compared with those who experience no decline or decline in either memory or gait speed only. A multicohort meta-analysis was performed of 6 prospective cohort studies conducted between 1997 and 2018 in the United States and Europe. Participants were 60 years or older, had an initial gait speed of more than 0.6 m/s (ie, free of overt dismobility), with repeated measures of memory and gait speed before dementia diagnosis during a mean follow-up of 6.6 to 14.5 years. Within each study, participants were divided into 4 groups: memory decline only, gait speed decline only, dual decline, or no decline (hereafter referred to as usual agers). Gait decline was defined as a loss of 0.05 m/s or more per year; memory decline was defined as being in the cohort-specific lowest tertile of annualized change. Risk of incident dementia according to group membership was examined by Cox proportional hazards regression with usual agers as the reference, adjusted for baseline age, sex, race/ethnicity, educational level, study site, and baseline gait speed and memory. Across the 6 studies of 8699 participants, mean age ranged between 70 and 74 years and mean gait speed ranged between 1.05 and 1.26 m/s. Incident dementia ranged from 5 to 21 per 1000 person-years. Compared with usual agers, participants with only memory decline had 2.2 to 4.6 times higher risk for developing dementia (pooled hazard ratio, 3.45 [95% CI, 2.45-4.86]). Those with only gait decline had 2.1 to 3.6 times higher risk (pooled hazard ratio, 2.24 [95% CI, 1.62-3.09]). Those with dual decline had 5.2 to 11.7 times the risk (pooled hazard ratio, 6.28 [95% CI, 4.56-8.64]). In this study, dual decline of memory and gait speed was associated with increased risk of developing dementia among older individuals, which might be a potentially valuable group for preventive or therapeutic interventions. Why dual decline is associated with an elevated risk of dementia and whether these individuals progress to dementia through specific mechanisms should be investigated by future studies.
Identifiants
pubmed: 32083691
pii: 2761549
doi: 10.1001/jamanetworkopen.2019.21636
pmc: PMC7043189
doi:
Types de publication
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1921636Subventions
Organisme : NIA NIH HHS
ID : P30 AG024827
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066507
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG034676
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG006786
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG028050
Pays : United States
Organisme : NINR NIH HHS
ID : R01 NR012459
Pays : United States
Commentaires et corrections
Type : ErratumIn
Références
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
Psychol Aging. 2013 Mar;28(1):262-74
pubmed: 23276211
Front Aging Neurosci. 2017 Oct 31;9:345
pubmed: 29163128
JAMA. 2000 Apr 19;283(15):2008-12
pubmed: 10789670
Int Psychogeriatr. 1997;9 Suppl 1:65-9
pubmed: 9447429
J Am Med Dir Assoc. 2016 Jun 1;17(6):482-90
pubmed: 26852960
J Gerontol A Biol Sci Med Sci. 2018 Aug 10;73(9):1265-1271
pubmed: 28977349
Stroke. 2011 Sep;42(9):2672-713
pubmed: 21778438
J Intern Med. 2004 Sep;256(3):183-94
pubmed: 15324362
J Am Geriatr Soc. 2018 Sep;66(9):1676-1683
pubmed: 29608780
J Am Geriatr Soc. 2000 Dec;48(12):1618-25
pubmed: 11129752
J Gerontol A Biol Sci Med Sci. 2013 Apr;68(4):412-8
pubmed: 22987797
Neurobiol Aging. 2005 Jul;26(7):987-94
pubmed: 15748776
Arch Neurol. 2009 Mar;66(3):300-5
pubmed: 19273747
J Gerontol A Biol Sci Med Sci. 2013 Aug;68(8):929-37
pubmed: 23250002
Neuroepidemiology. 2008;30(1):58-69
pubmed: 18259084
Alzheimers Dement. 2014 Nov;10(6):735-742.e4
pubmed: 25035155
Exp Gerontol. 2019 Sep;124:110625
pubmed: 31173841
J Gerontol A Biol Sci Med Sci. 2017 Feb;72(2):266-270
pubmed: 27927757
J Nutr Health Aging. 2009 Jun;13(6):538-44
pubmed: 19536422
Age Ageing. 2017 Sep 1;46(5):729-738
pubmed: 28541374
Aging Clin Exp Res. 2004 Apr;16(2):158-68
pubmed: 15195992
Acta Neuropathol. 2011 May;121(5):571-87
pubmed: 21516511
J Neurol Neurosurg Psychiatry. 2006 Feb;77(2):159-65
pubmed: 16103044
Neurology. 2014 Aug 19;83(8):718-26
pubmed: 25031288
Cochrane Database Syst Rev. 2019 Oct 3;10:ED000142
pubmed: 31643080
JAMA. 2014 May;311(20):2061-2
pubmed: 24763978
J Gerontol A Biol Sci Med Sci. 2009 Jan;64(1):96-102
pubmed: 19164274
Am J Epidemiol. 2007 May 1;165(9):1076-87
pubmed: 17351290
JAMA. 2011 Jan 5;305(1):50-8
pubmed: 21205966
Exp Gerontol. 2018 Sep;110:146-150
pubmed: 29879449
J Am Geriatr Soc. 1992 Sep;40(9):922-35
pubmed: 1512391
Neurosci Biobehav Rev. 2016 May;64:326-45
pubmed: 26915926
Neurology. 2013 Aug 6;81(6):528-33
pubmed: 23902706
J Alzheimers Dis. 2017;59(1):77-84
pubmed: 28582865
J Am Geriatr Soc. 2018 Sep;66(9):1659-1660
pubmed: 29608781
Ageing Res Rev. 2010 Oct;9(4):399-417
pubmed: 20444434
J Gerontol A Biol Sci Med Sci. 2019 May 16;74(6):943-948
pubmed: 29917045
Front Med (Lausanne). 2017 Oct 25;4:166
pubmed: 29119100
J Gerontol A Biol Sci Med Sci. 2013 Apr;68(4):409-11
pubmed: 23401565
JAMA. 2004 Jun 23;291(24):2959-68
pubmed: 15213207
Mol Neurobiol. 2016 Nov;53(9):6078-6090
pubmed: 26537901
J Gerontol A Biol Sci Med Sci. 2015 Mar;70(3):319-24
pubmed: 25380599
Acta Neuropathol. 2016 May;131(5):645-58
pubmed: 26711459
J Gerontol A Biol Sci Med Sci. 2014 Nov;69(11):1375-88
pubmed: 24739495
J Am Geriatr Soc. 2003 Mar;51(3):323-30
pubmed: 12588575
J Gerontol A Biol Sci Med Sci. 2017 May 1;72(5):655-661
pubmed: 27302701
Gait Posture. 2017 Mar;53:215-223
pubmed: 28222369
Free Radic Biol Med. 2016 Nov;100:108-122
pubmed: 27154981
Alzheimers Dement. 2015 Jun;11(6):710-7
pubmed: 25510382
Neurology. 1974 Nov;24(11):1019-25
pubmed: 4473151